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Cellular Latency in HIV-1 Infection
Clinics in Laboratory Medicine, 1994There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1 LTR.
M A, Laughlin, R J, Pomerantz
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Generation of HIV latency during thymopoiesis
Nature Medicine, 2001The use of combination antiretroviral therapy results in a substantial reduction in viremia, a rebound of CD4+ T cells and increased survival for HIV-infected individuals. However, this treatment does not result in the total eradication of HIV. Rather, the virus is thought to remain latent in a subset of cells, where it avoids elimination by the immune
D G, Brooks +4 more
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Underlying mechanisms of HIV-1 latency
Virus Genes, 2017Similarly to other retroviruses, HIV-1 integrates its genome into the cellular chromosome. Expression of viral genes from the integrated viral DNA could then be regulated by the host genome. If the infected cell suppresses viral gene expression, the virus will undergo latency.
Bizhan Romani, Elham Allahbakhshi
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A unified concept of HIV latency
Expert Opinion on Biological Therapy, 2006The introduction of highly active antiretroviral therapy (HAART) combining potent drugs that can inhibit reverse transcriptase, integrase and protease activities has changed the natural history of the human immunodeficiency virus (HIV) type 1 disease. Unfortunately, poor penetrability into different anatomic compartments, toxicity and drug resistance ...
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The Molecular Biology of HIV Latency
2018HIV remains incurable due to the existence of a reservoir of cells that harbor intact integrated genomes of the virus in the absence of viral replication. This population of infected cells remains invisible to the immune system and is not targeted by the drugs used in the current antiretroviral therapies (cART).
Khoury, Georges +6 more
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Phylogenies in ART: HIV reservoirs, HIV latency and drug resistance
Current Opinion in Pharmacology, 2019Combination antiretroviral therapy (ART) has significantly reduced the morbidity and mortality resulting from HIV infection. ART is, however, unable to eradicate HIV, which persists latently in several cell types and tissues. Phylogenetic analyses suggested that the proliferation of cells infected before ART initiation is mainly responsible for ...
Bandera A. +3 more
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Molecular mechanisms of HIV-1 proviral latency
Expert Review of Anti-infective Therapy, 2005While great strides have been made in the treatment of HIV infection with highly active antiretroviral therapy, an actual cure remains out of grasp. One confounding factor is the persistence of a small population of infected cells containing transcriptionally silent but reactivatable HIV proviruses.
Dwayne, Bisgrove +3 more
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Primary cell models of HIV latency
Current Opinion in HIV and AIDS, 2011To provide updated points of view regarding the recent development and application of in-vitro primary cell models of HIV latency and their potential application in future studies of HIV eradication.It has been challenging to develop a primary cell model of HIV latency that can authentically recapitulate the quiescent features of resting CD4+ T cells ...
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Cervical cancer prevention and control in women living with human immunodeficiency virus
Ca-A Cancer Journal for Clinicians, 2021Philip E Castle, Vikrant V Sahasrabuddhe
exaly