Results 11 to 20 of about 28,737 (162)
A Hardwired HIV Latency Program [PDF]
Cell, 2015 Biological circuits can be controlled by two general schemes: environmental sensing or autonomous programs. For viruses such as HIV, the prevailing hypothesis is that latent infection is controlled by cellular state (i.e., environment), with latency simply an epiphenomenon of infected cells transitioning from an activated to resting state.
Razooky, Brandon S +4 more
openaire +6 more sources
The mTOR Complex Controls HIV Latency [PDF]
Cell Host & Microbe, 2016 A population of CD4 T lymphocytes harboring latent HIV genomes can persist in patients on antiretroviral therapy, posing a barrier to HIV eradication. To examine cellular complexes controlling HIV latency, we conducted a genome-wide screen with a pooled ultracomplex shRNA library and in vitro system modeling HIV latency and identified the mTOR complex ...
Besnard, Emilie +18 more
openaire +6 more sources
Bridging HIV-1 cellular latency and clinical long-term non-progressor: an interactomic view. [PDF]
PLoS ONE, 2013 Development of an effective HIV management is enticed by the fact that long-term non-progressors (LTNP) restrict viral replication spontaneously, but is hindered by HIV-1 latency.
Jin Yang +5 more
doaj +1 more source
mBio, 2021 HIV-1 remains incurable due to viral reservoirs, which lead to durably latent HIV infection. Identifying novel host factors and deciphering the molecular mechanisms involved in the establishment and maintenance of latency are critical to discover new ...
Taizhen Liang +6 more
doaj +1 more source
A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
mBio, 2021 To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat).
Michael Röling +13 more
doaj +1 more source
MicroRNA-155 Reinforces HIV Latency [PDF]
Journal of Biological Chemistry, 2015 The presence of a small number of infected but transcriptionally dormant cells currently thwarts a cure for the more than 35 million individuals infected with HIV. Reactivation of these latently infected cells may result in three fates: 1) cell death due to a viral cytopathic effect, 2) cell death due to immune clearance, or 3) a retreat into latency ...
Ruelas, Debbie S +8 more
openaire +4 more sources
HIV-1 Latency by Transition [PDF]
Immunity, 2017 The latent HIV-1 reservoir represents the major barrier for the development of an HIV-1 cure. In this issue of Immunity, Shan et al. (2017) highlight that effector-to-memory transitioning (EMT) CD4+ T cells are particularly permissive for the establishment of latent HIV-1 infection.
Boris, Julg, Dan H, Barouch
openaire +2 more sources
Molecular mechanisms of HIV latency [PDF]
Journal of Clinical Investigation, 2016 HIV seeds reservoirs of latent proviruses in the earliest phases of infection. These reservoirs are found in many sites, including circulating cells, the lymphoid system, the brain, and other tissues. The "shock and kill" strategy, where HIV transcription is reactivated so that antiretroviral therapy and the immune system clear the infection, has been ...
Daniele C, Cary +2 more
openaire +2 more sources
Journal of Virus Eradication, 2023 A better understanding of HIV-1 latency is a research priority in HIV cure research. Conversely, little is known about the latency characteristics of HIV-2, the closely related human lentivirus.
Anne Bruggemans +3 more
doaj +1 more source
Diverse effects of interferon alpha on the establishment and reversal of HIV latency.
PLoS Pathogens, 2020 HIV latency is the major barrier to a cure for people living with HIV (PLWH) on antiretroviral therapy (ART) because the virus persists in long-lived non-proliferating and proliferating latently infected CD4+ T cells.
Renée M Van der Sluis +16 more
doaj +1 more source