Results 21 to 30 of about 28,737 (162)
Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal
EBioMedicine, 2016 Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds capable of HIV-1 latency reversal in order to render infected cells ...
Mateusz Stoszko +10 more
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HIV Latency: Stochastic across Multiple Scales [PDF]
Cell Host & Microbe, 2019 Proviral latency is a major barrier to a cure for HIV. In this issue of Cell Host & Microbe, Hataye et al. (2019) show that reactivation of HIV latency is a non-deterministic, highly stochastic (i.e., noisy) process and propose that stochastic transitions to exponential viral expansion require a critical threshold of virus.
Hansen, M.M.K. +2 more
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Cell Host & Microbe, 2016 Combination therapy for HIV infection is effective at controlling disease but fails to eradicate the virus because a persistent reservoir of cells harbors latent HIV DNA. In this issue of Cell Host & Microbe, Besnard et al. (2016) show that the mTOR kinase is essential to reactivate HIV from latency.
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Understanding Factors That Modulate the Establishment of HIV Latency in Resting CD4+ T-Cells In Vitro. [PDF]
PLoS ONE, 2016 Developing robust in vitro models of HIV latency is needed to better understand how latency is established, maintained and reversed. In this study, we examined the effects of donor variability, HIV titre and co-receptor usage on establishing HIV latency ...
Jenny L Anderson +9 more
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Selective miRNA Modulation Fails to Activate HIV Replication in In Vitro Latency Models
Molecular Therapy: Nucleic Acids, 2019 HIV remains incurable because of viral persistence in latent reservoirs that are inaccessible to antiretroviral therapy. A potential curative strategy is to reactivate viral gene expression in latently infected cells.
María Rosa López-Huertas +9 more
doaj +1 more source
mBio, 2020 Reversible repression of HIV-1 5′ long terminal repeat (5′-LTR)-mediated transcription represents the main mechanism for HIV-1 to maintain latency.
Li Ma +7 more
doaj +1 more source
Chromatin, gene silencing and HIV latency [PDF]
Genome Biology, 2007 One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral ...
Mok, Hoi-Ping, Lever, Andrew ML
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Communications Biology, 2023 Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood.
Mie Kobayashi-Ishihara +22 more
doaj +1 more source
Frontiers in Microbiology, 2022 Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral ...
Lilly M. Wong +8 more
doaj +1 more source
Molecular Understanding of HIV-1 Latency [PDF]
Advances in Virology, 2012 The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough in the treatment of HIV-1 infection and has also a powerful tool to upset the equilibrium of viral production and HIV-1 pathogenesis. Despite the advent of potent combinations of this therapy, the long-lived HIV-1 reservoirs like cells from monocyte ...
W. Abbas, G. Herbein
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