Results 31 to 40 of about 28,737 (162)
HIV reservoirs and latency models
Virology, 2011 The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells.
Pace, Matthew J. +3 more
openaire +2 more sources
HIV-1 Latency in Monocytes/Macrophages [PDF]
Viruses, 2014 Human immunodeficiency virus type 1 (HIV-1) targets CD4+ T cells and cells of the monocyte/macrophage lineage. HIV pathogenesis is characterized by the depletion of T lymphocytes and by the presence of a population of cells in which latency has been established called the HIV-1 reservoir.
Amit Kumar, Wasim Abbas, Georges Herbein
openaire +3 more sources
Emerging Microbes and Infections, 2022 HIV-1 latency posts a major obstacle for HIV-1 eradication. Currently, no desirable latency reversing agents (LRAs) have been implicated in the “Shock and Kill” strategy to mobilize the latently infected cells to be susceptible for clearance by immune ...
Jing Wen +12 more
doaj +1 more source
Identify Potential Regulators in HIV-1 Latency by Joint microRNA and mRNA Analysis
Cellular Physiology and Biochemistry, 2015 Background/Aims: The main obstacle to cure HIV infection is the existence of long-lasting latent reservoirs. Many efforts have been made to understand basal mechanisms of HIV-1 latency, in which miRNAs play an important role. However, integrated analysis
Zongxing Yang +6 more
doaj +1 more source
PLoS Pathogens, 2023 Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1.
Emily Hsieh +6 more
doaj +1 more source
Tracking HIV Rebound following Latency Reversal Using Barcoded HIV [PDF]
Cell Reports Medicine, 2020 HIV latency prevents cure of infection with antiretroviral therapy (ART) alone. One strategy for eliminating latently infected cells involves the induction of viral protein expression via latency-reversing agents (LRAs), allowing killing of host cells by viral cytopathic effects or immune effector mechanisms.
Matthew D. Marsden +11 more
openaire +4 more sources
Cell Reports, 2018 Summary: Despite effective treatment, HIV can persist in latent reservoirs, which represent a major obstacle toward HIV eradication. Targeting and reactivating latent cells is challenging due to the heterogeneous nature of HIV-infected cells.
Monica Golumbeanu +6 more
doaj +1 more source
PLoS Pathogens, 2016 The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in HIV ...
Cory H White +9 more
doaj +1 more source
Cell Reports, 2018 Summary: A detailed understanding of the mechanisms that establish or maintain the latent reservoir of HIV will guide approaches to eliminate persistent infection. We used a cell line and primary cell models of HIV latency to investigate viral RNA (vRNA)
Todd Bradley +4 more
doaj +1 more source
Heliyon, 2019 HIV-1 persists during antiretroviral therapy (ART) due to long-lived and proliferating latently-infected host cells, with the outcome being an incomplete cure. The latently-infected cells, or reservoir cells, are transcriptionally absent and invisible to
Jutatip Panaampon +3 more
doaj +1 more source