Results 61 to 70 of about 28,737 (162)

Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretroviral Therapy

Cell Reports, 2019
Summary: Latent proviruses persist in central (TCM), transitional (TTM), and effector (TEM) memory cells. We measured the levels of cellular factors involved in HIV gene expression in these subsets.
Marion Pardons, Rémi Fromentin, Amélie Pagliuzza, Jean-Pierre Routy, Nicolas Chomont   +4 more
doaj   +1 more source

Mathematical Analysis of the Role of HIV/HBV Latency in Hepatocytes

Journal of Applied Mathematics, 2021
The biggest challenge of treating HIV is rampant liver-related morbidity and mortality. This is, to some extent, attributed to hepatocytes acting as viral reservoirs to both HIV and HBV. Viral reservoirs harbour latent provirus, rendering it inaccessible
Hasifa Nampala, Matylda Jablonska-Sabuka, Martin Singull   +2 more
doaj   +1 more source

Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

Clinical Epigenetics, 2018
HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART.
Sheraz Khan, Mazhar Iqbal, Muhammad Tariq, Shahid M. Baig, Wasim Abbas   +4 more
doaj   +1 more source

HIV Latency in the Humanized BLT Mouse [PDF]

Journal of Virology, 2012
ABSTRACT Even after extended treatment with powerful antiretroviral drugs, HIV is not completely eliminated from infected individuals. Latently infected CD4 + T cells constitute one reservoir of replication-competent HIV that needs to be eliminated to completely purge virus ...
Matthew D, Marsden, Michael, Kovochich, Nuttee, Suree, Saki, Shimizu, Roshni, Mehta, Ruth, Cortado, Gregory, Bristol, Dong Sung, An, Jerome A, Zack   +8 more
openaire   +2 more sources

An Evaluation on the Role of Non-Coding RNA in HIV Transcription and Latency: A Review

HIV/AIDS: Research and Palliative Care, 2023
Peter W Ramirez,1 Christina Pantoja,1 Nadejda Beliakova-Bethell2,3 1Department of Biological Sciences, California State University, Long Beach, CA, USA; 2VA San Diego Healthcare System and Veterans Medical Research Foundation, San Diego, CA, USA ...
Ramirez PW, Pantoja C, Beliakova-Bethell N   +2 more
doaj  

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency

Annual Review of Pharmacology and Toxicology, 2011
HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral latency established within the host genome remains largely unaffected by ART and can replenish systemic infection following interruption of therapy.
Shailesh K, Choudhary, David M, Margolis
openaire   +3 more sources

Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?

Viruses
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts.
Mie Kobayashi-Ishihara, Yasuko Tsunetsugu-Yokota   +1 more
doaj   +1 more source

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

iScience
Summary: HIV-1 latency results from tightly regulated molecular processes that act at distinct steps of HIV-1 gene expression. Here, we characterize PCI domain-containing 2 (PCID2) protein, a subunit of the transcription and export complex 2 (TREX2 ...
Raquel Crespo, Enrico Ne, Julian Reinders, Jenny I.J. Meier, Chengcheng Li, Sanne Jansen, Alicja Górska, Selin Koçer, Tsung Wai Kan, Wouter Doff, Dick Dekkers, Jeroen Demmers, Robert-Jan Palstra, Shringar Rao, Tokameh Mahmoudi   +14 more
doaj   +1 more source

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells

iScience
Summary: HIV-1 latency is regulated by chromatin modifying enzymes, and histone deacetylase inhibitors (HDACi) cause reactivation of provirus expression.
Riley M. Horvath, Ivan Sadowski
doaj   +1 more source

Dendritic cells potently purge latent HIV-1 beyond TCR-stimulation, activating the PI3K-Akt-mTOR pathwayResearch in context

EBioMedicine, 2019
Background: The latent HIV-1 reservoir in treated patients primarily consists of resting memory CD4+ T cells. Stimulating the T-cell receptor (TCR), which facilitates transition of resting into effector T cells, is the most effective strategy to purge ...
Thijs van Montfort, Renée van der Sluis, Gilles Darcis, Doyle Beaty, Kevin Groen, Alexander O. Pasternak, Georgios Pollakis, Monique Vink, Ellen M. Westerhout, Mohamed Hamdi, Margreet Bakker, Boas van der Putten, Suzanne Jurriaans, Jan H. Prins, Rienk Jeeninga, Adri A.M. Thomas, Dave Speijer, Ben Berkhout   +17 more
doaj   +1 more source