Results 71 to 80 of about 795,110 (304)

Anti-HLA I antibodies induce VEGF production by endothelial cells, which increases proliferation and paracellular permeability

, 2009
Anti-human leukocyte antigen class I (HLA I) antibodies were shown to activate several protein kinases in endothelial cells (ECs), which induces proliferation and cell survival.
Ligeti, Nathalie, Bieri, Jürg, Bieri, Michael, Mohacsi, Paul, Farkas, Anikò, Oroszlan, Melinda, Mohacsi P, Oroszlan M, Bieri J, Bieri M, Ligeti N, Farkas A, Nathalie Ligeti, Jürg Bieri, Melinda Oroszlan, Paul Mohacsi, Michael Bieri, Anikò Farkas   +17 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Novel method for simultaneously detecting HPA and HLA antibodies using Luminex microbeads

Journal of Translational Medicine, 2019
Background Alloantibodies against human platelet antigens (HPAs) and human leukocyte antigen (HLA) are implicated in several immune-mediated platelet disorders.
Sudan Tao, Shu Chen, Xiaozhen Hong, Ji He, Faming Zhu   +4 more
doaj   +1 more source

Anti-phospholipid-antibodies in patients with relapsing polychondritis [PDF]

, 1998
Relapsing polychondritis (RP) is an extremly rare multisystemic disease thought to be of autoimmune origin. In order to assess if RP is associated with anti-phospholipid antibodies (aPL), clinical data and sera of 21 patients with RP were collected in a ...
Schlosser, U., Schmitz, G., Lang, B., Zeuner, M., Straub, R. H., Rauh, G., Schòlmerich, J.   +6 more
core   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Anticuerpos contra células del trofoblasto en el primer trimestre del embarazo Antibodies against trophoblast cells in the first quarter of pregnancy

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2011
Las células del trofoblasto no expresan los antígenos HLA clásicos de clase I (A, B, C), pero sí los antígenos HLA G que pueden generar anticuerpos capaces de tener reacción cruzada con los primeros.
María E Alfonso-Valdés, Eduardo Muñiz, Antonio Bencomo-Hernández, Rodisnel Rodríguez-Leyva, Déborah Villegas-Cruz, Rosa M Lam-Díaz, Luz M Morera-Barrios, Lisette Orbeal-Aldama, Gladys Graña-Ayllón   +8 more
doaj  

Usefulness of the nonself-self algorithm of HLA epitope immunogenicity in the specificity analysis of monospecific antibodies induced during pregnancy

Frontiers in Immunology, 2015
Background HLAMatchmaker is a program to analyze the epitope specificities of HLA antibodies. It considers each HLA allele as a string of eplets. Intralocus and interlocus comparisons between donor and recipient alleles offer a structural assessment of
Rene J Duquesnoy, Marilyn eMarrari, Arend eMulder   +2 more
doaj   +1 more source

Interference between anti-HLA antibodies and CPZ metabolites

, 1980
The interference of chlorpromazine (CPZ) and several preincubated CPZ metabolites on the lymphocyte absorption of antibodies directed against HLA-A1 and other nonrelated HLA specificities were investigated. Both CPZ and metabolites 7-OH-, Nor1-, and Nor2-
G. Fabio, E. Smeraldi, R. Scorza-Smeraldi, F. Negri   +3 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source