Results 51 to 60 of about 795,110 (304)

Analysis of HLA allele-specific antibodies and Eplets in patients with platelet transfusion refractoriness

Zhongguo shuxue zazhi, 2022
Objective To analyze the specificity and Eplets of HLA allele-specific antibody in patients with platelet transfusion refractoriness (PTR). Methods HLA-A and B genotypes were detected by PCR-SBT, and HLA-Ⅰ antibodies in patients′ serum were detected by ...
Bing ZHANG, Xinyu HUANG, Ying LIU, Gang XU, Shu CHEN, Xianguo XU, Faming ZHU   +6 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Effect Modification of Cigarette Smoking on the Relationship Between Posttraumatic Stress Disorder, Other Mental Health Conditions, and Rheumatoid Arthritis Risk: A Large Case‐Control Study in US Veterans

Arthritis Care &Research, EarlyView.
Objective We examined associations of posttraumatic stress disorder (PTSD) and other mental health disorders (OMH) with rheumatoid arthritis (RA), accounting for effects of smoking. Methods We conducted a matched case‐control study, identifying incident RA cases and controls using national Veterans Health Administration data (2006–2019).
Kelsey Coziahr, Harlan Sayles, Tate M. Johnson, Joshua F. Baker, Punyasha Roul, Grant W. Cannon, Gary A. Kunkel, Katherine D. Wysham, Gail S. Kerr, Amir A. Razmjou, Isaac Smith, Jennifer L. Barton, Maria I. Danila, Jonathan S. Richards, Bryant R. England, Ted R. Mikuls   +15 more
wiley   +1 more source

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study [PDF]

, 2009
Background: Mounting evidence indicates that HLA-mediated HIV evolution follows highly stereotypic pathways that result in HLA-associated footprints in HIV at the population level.
Santiago Avila-Rios, Avila-Rios, S., Brumme, Z.L., Espinosa Enrique, Carlson, J.M., Valenzuela-Ponce Humberto, Carlson Jonathan M, John Mina, Ormsby Christopher E, David Heckerman, Heckerman, D., Juan Blanco-Heredia, Blanco-Heredia Juan, Mallal Simon, Brumme Zabrina L, Daniela Garrido-Rodriguez, Espinosa, E., Enrique Espinosa, Reyes-Teran Gustavo, Garrido-Rodriguez, D., Ormsby, C.E., Valenzuela-Ponce, H., Garcia-Morales Claudia, Zabrina L Brumme, John, M., Heckerman David, Simon Mallal, Gustavo Reyes-Teran, Claudia Garcia-Morales, Christopher E Ormsby, Humberto Valenzuela-Ponce, Garrido-Rodriguez Daniela, Avila-Rios Santiago, Mina John, Garcia-Morales, C., Jonathan M Carlson, Reyes-Teran, G., Blanco-Heredia, J., Mallal, S.   +38 more
core   +1 more source

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source

Challenges and opportunities in bringing non-HLA antibody testing for post-transplant monitoring

Frontiers in Transplantation
Evidence for the contribution of non-HLA antibodies on long-term allograft outcome was suggested in early studies by Paul Terasaki and colleagues who showed worse 10-year allograft outcome in HLA identical kidney transplant recipients with a positive ...
Mary Carmelle Philogene, Inna Tchoukina, Idoia Gimferrer   +2 more
doaj   +1 more source

Matching strategy for patients with platelet transfusion refractoriness caused by compound antibodies against HLA and CD36

Zhongguo shuxue zazhi, 2023
Objective To search compatible and suitable platelets for platelet transfusion refractoriness (PTR) patient caused by compound antibodies against HLA and CD36.
Jing DENG, Xiuzhang XU, Huibin ZHONG, Bi ZHONG, Yangkai CHEN, Jing LIU, Haoqiang DING, Wenjie XIA, Dawei CHEN, Yaori XU, Xin YE   +10 more
doaj   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Establishment of Anti-HLA Antibodies in the Sera of Multiparous Pregnant

Eurasian Journal of Medicine, 2019
Objective: It is well known that anti-HLA(Human leucocyte antigen) antibodies have great importance for tissue transplantation. These antibodies were first established in the serum of several blood transfused patients.
Nilnur Eyerci, Gönül Zişan Öncel, Metin İngeç, Atilla Topçu, İbrahim Pirim   +4 more
doaj  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source