Results 31 to 40 of about 41,460 (160)

Different Origins of Newcastle Disease Virus Hemagglutinin-Neuraminidase Protein Modulate the Replication Efficiency and Pathogenicity of the Virus

Frontiers in Microbiology, 2017
To investigate the exact effects of different origins of Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) protein to the biological characteristics of the virus, we systematically studied the correlation between the HN protein and NDV ...
Ji-hui Jin, Jin-long Cheng, Zi-rong He, Ying-chao Ren, Xiao-hui Yu, Yang Song, Hui-ming Yang, Yan-ling Yang, Tong Liu, Guo-zhong Zhang, Guo-zhong Zhang   +10 more
doaj   +1 more source

A Mutation in the Stalk of the Newcastle Disease Virus Hemagglutinin-Neuraminidase (HN) Protein Prevents Triggering of the F Protein despite Allowing Efficient HN-F Complex Formation [PDF]

Journal of Virology, 2013
ABSTRACT Newcastle disease virus (NDV)-induced membrane fusion requires formation of a complex between the hemagglutinin-neuraminidase (HN) and fusion (F) proteins. Substitutions for NDV HN stalk residues A89, L90, and L94 block fusion by modulating formation of the HN-F complex.
Mirza, Anne M., Iorio, Ronald M.
openaire   +3 more sources

Newcastle Disease Virus HN Protein Alters the Conformation of the F Protein at Cell Surfaces [PDF]

Journal of Virology, 2002
ABSTRACT Conformational changes in the Newcastle disease virus (NDV) fusion (F) protein during activation of fusion and the role of HN protein in these changes were characterized with a polyclonal antibody. This antibody was raised against a peptide with the sequence of the amino-terminal half of the F protein HR1 domain.
Cullen, Lori McGinnes, Gravel, Kathryn A., Morrison, Trudy G.   +2 more
openaire   +3 more sources

HN-PPISP: a hybrid network based on MLP-Mixer for protein–protein interaction site prediction

Briefings in Bioinformatics, 2022
AbstractMotivationBiological experimental approaches to protein–protein interaction (PPI) site prediction are critical for understanding the mechanisms of biochemical processes but are time-consuming and laborious. With the development of Deep Learning (DL) techniques, the most popular Convolutional Neural Networks (CNN)-based methods have been ...
Yan, Kang, Yulong, Xu, Xinchao, Wang, Bin, Pu, Xuekun, Yang, Yulong, Rao, Jianguo, Chen   +6 more
openaire   +2 more sources

Protein backbone motions viewed by intraresidue and sequential HN–Hα residual dipolar couplings [PDF]

Journal of Biomolecular NMR, 2008
Triple resonance E.COSY-based techniques were used to measure intra-residue and sequential H(N)-H(alpha) residual dipolar couplings (RDCs) for the third IgG-binding domain of protein G (GB3), aligned in Pf1 medium. Measurements closely correlate with values predicted on the basis of an NMR structure, previously determined on the basis of a large number
Beat, Vögeli, Lishan, Yao, Ad, Bax
openaire   +2 more sources

Determination of HN,H? and HN,C? coupling constants in 13C, 15N-labeled proteins

Journal of Biomolecular NMR, 1994
Sensitive three-dimensional NMR experiments, based on the E.COSY principle, are presented for the measurement of the (3)J(H(N),H(α)) and (3)J(H(N),C') coupling constants in uniformly (13)C- and (15)N-labeled proteins. They employ gradient coherence selection in combination with the sensitivity enhancement method in HSQC-type spectra (Cavanagh et al ...
Weisemann, R., Rüterjans, H., Schwalbe, H., Schleucher, J., Bermel, W., Griesinger, C.   +5 more
openaire   +3 more sources

An efficient liposomal gene delivery vehicle using Sendai F/HN proteins and protamine [PDF]

Cancer Gene Therapy, 2008
By means of a simple mixing procedure, we have constructed cationic Sendai virosomes consisting of fusogenic viral F/HN proteins and cationic lipids. Sendai virus F/HN proteins were purified by Triton X-100 treatment and sequential centrifugation, and then quantitatively added to cationic liposomes.
H S, Kim, J S, Kim, Y K, Lee, K H, Koo, Y S, Park   +4 more
openaire   +2 more sources

Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement

mBio, 2015
In order to deliver their genetic material to host cells during infection, enveloped viruses use specialized proteins on their surfaces that bind cellular receptors and induce fusion of the viral and host membranes.
Long Gui, Eric M. Jurgens, Jamie L. Ebner, Matteo Porotto, Anne Moscona, Kelly K. Lee   +5 more
doaj   +1 more source

Functional EL-HN Fragment as a Potent Candidate Vaccine for the Prevention of Botulinum Neurotoxin Serotype E

Toxins, 2022
Clostridium botulinum produces botulinum neurotoxin (BoNT), which is the most toxic known protein and the causative agent of human botulism. BoNTs have similar structures and functions, comprising three functional domains: catalytic domain (L ...
Zhen Li, Jiansheng Lu, Xiao Tan, Rong Wang, Qing Xu, Yunzhou Yu, Zhixin Yang   +6 more
doaj   +1 more source

Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo

mBio, 2013
Paramyxoviruses, enveloped RNA viruses that include human parainfluenza virus type 3 (HPIV3), cause the majority of childhood viral pneumonia. HPIV3 infection starts when the viral receptor-binding protein engages sialic acid receptors in the lung and ...
Rui Xu, Samantha G. Palmer, Matteo Porotto, Laura M. Palermo, Stefan Niewiesk, Ian A. Wilson, Anne Moscona   +6 more
doaj   +1 more source