Results 101 to 110 of about 465,102 (291)
Total flavonoids of Selaginella tamariscina (P. Beauv.) Spring ameliorates diabetes-induced acute lung injury via activating Nrf2/ HO-1 [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): This investigation explored the mechanism by which the total flavonoids of Selaginella tamariscina (P.Beauv.) Spring (TFST) mitigate oxidative stress through the activation of the heme oxygenase-1 (HO-1) signaling pathway mediated by ...
Lina Chen +4 more
doaj +1 more source
The role of Nrf2 in astragaloside IV-mediated antioxidative protection on heart failure
Pharmaceutical Biology, 2020 Context Heart failure is one of the most serious diseases worldwide. Astragaloside IV (ASI) is widely used in the treatment of cardiovascular diseases.
Yan-Bo Sui +4 more
doaj +1 more source
Prevalence and Trajectory of Household Material Hardship Among Children With Advanced Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Families of children with advanced cancer living in poverty experience inferior outcomes including poor parent mental health and worse child quality of life. Household material hardship (HMH: food, housing, transportation, and/or utility insecurity) is a modifiable poverty exposure—and potential intervention target—that ...
Sarah Wright +13 more
wiley +1 more source
Targeting the Nrf2-Heme Oxygenase-1 Axis after Intracerebral Hemorrhage. [PDF]
, 2017 BACKGROUND: Injury to cells adjacent to an intracerebral hemorrhage (ICH) is likely mediated at least in part by toxins released from the hematoma that initiate complex and interacting injury cascades.
Chen-Roetling, Jing, Regan, Raymond F.
core +1 more source
Differential gene expression of NADPH oxidase (p22phox) and hemoxygenase-1 in patients with Type 2 diabetes and microangiopathy [PDF]
, 2006 Aims: While the downstream effects of increased reactive oxygen species (ROS) in the pathogenesis of diabetes were well studied, only a few studies have explored the cellular sources of ROS.
Adaikalakoteswari, A +3 more
core +1 more source
Molecules, 2012 Intestinal ischemia reperfusion (IIR) is a serious clinical condition associated with simultaneous multiple organ dysfunction. The aim of this study was to investigate the effects of ginsenoside Rb1 on IIR induced renal injury in mice.
Zhong-Yuan Xia +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Families of children with cancer experience significant financial strain, even with universal healthcare. Indirect costs, such as productivity losses and non‐medical expenses, are rarely included in economic evaluations, and little is known about how effectively financial aid programmes alleviate this burden. Childhood brain tumours
Megumi Lim +8 more
wiley +1 more source
PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis [PDF]
, 2015 Aims Vascular injury leading to endothelial dysfunction is a characteristic feature of chronic renal disease, diabetes mellitus, and systemic inflammatory conditions, and predisposes to apoptosis and atherogenesis.
Al-Huseini +60 more
core +1 more source
NRF2/HO-1 axis regulates fructose-induced lipid accumulation in hepatocytes
Redox Experimental MedicineObjective: Nuclear factor erythroid 2-related factor 2 (NRF2), a key transcription factor involved in redox homeostasis, plays a critical role in preventing lipid peroxidation against various hepatic disorders, including metabolic dysfunction-associated ...
Bengu Cetinkaya +6 more
doaj +1 more source
Role of HO‐1 in neuroblastoma resistance to Bortezomib
The FASEB Journal, 2013 Neuroblastoma (NB) is the most common solid tumor in childhood and is characterized by a poor prognosis due to the gain of a chemoresistant phenotype. Among the most recent anticancer therapies Bortezomib (BTZ) has shown impressive clinical activity to overcome cancer cell resistance to conventional therapy.
FURFARO, ANNA LISA +8 more
openaire +2 more sources