Results 81 to 90 of about 465,102 (291)

Elucidating the Role of Nrf2 Signaling Pathway in Mycoplasma Infections

Frontiers in Bioscience-Landmark
Mycoplasmas are the smallest cell-wall-less self-replicating prokaryotes. Mycoplasma species can be found within and outside cells as “silent parasites” that live intracellularly and as membrane surface parasites.
Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova, Ekaterina Neborak, Natallia Zhabo   +4 more
doaj   +1 more source

Heme and HO-1 Inhibition of HCV, HBV, and HIV [PDF]

Frontiers in Pharmacology, 2012
Hepatitis C virus, human immunodeficiency virus, and hepatitis B virus are chronic viral infections that cause considerable morbidity and mortality throughout the world. In the decades following the identification and sequencing of these viruses, in vitro experiments demonstrated that heme oxygenase-1, its oxidative products, and related compounds of ...
Warren N Schmidt, Warren N Schmidt, Mary M Mathahs, Mary M Mathahs, Zhaowen eZhu, Zhaowen eZhu   +5 more
openaire   +3 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Effects of heme oxygenase isozymes on Leydig cells steroidogenesis [PDF]

, 2009
In the present study, we demonstrate the expression of heme oxygenase (HO) isozymes, HO-1 and HO-2 (listed as HMOX1 and HMOX2 in the MGI Database), in MA-10 Leydig tumor cells and its effect on steroidogenesis. The well-known HO inducer, hemin, increased
Besio Moreno, Marcos Alberto, Cymeryng, Cora Betriz, Monzón, Casandra Margarita, Pagotto, Romina María del Luján, Pignataro, Omar Pedro, Piotrkowski, Barbara, Reche, Cecilia   +6 more
core   +1 more source

Chlorogenic acid protects against cisplatin-induced testicular damage: a biochemical and histological study

Arhiv za Higijenu Rada i Toksikologiju
One of the adverse effects of cisplatin (CIS) treatment is its reproductive toxicity, which limits its clinical use in male patients. The aim of our study was to investigate the potential protective effects and mechanisms of chlorogenic acid (CHA), a ...
Demir Elif Ayazoğlu, Demir Selim, Mungan Sevdegül Aydın, Alemdar Nihal Türkmen, Menteşe Ahmet, Aliyazıcıoğlu Yüksel   +5 more
doaj   +1 more source

Melatonin protects against burn-induced hepatic oxidative injury by inducing HO-1 via the Nrf2 pathway

Veterinární Medicína, 2015
Melatonin exerts beneficial effects on early liver injury by modulating hepatic oxidative stress. In order to understand the protective effect of melatonin against burn-induced hepatic injury we investigated the expression of 4-hydroxynonenal (4-HNE), a ...
G. Bekyarova, M. Tzaneva, M. Hristova
doaj   +1 more source

Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells [PDF]

BMB Reports, 2013
Adhesion molecules such as ICAM-1 are important in theinfiltration of leukocytes into the site of inflammation. In thisstudy, we investigated the inhibitory effects of curcumin onICAM-1 expression and monocyte adhesiveness as well as itsunderlying action
Gi Soo Youn, Dong-Joo Kwon, Sung Mi Ju, Soo Young Choi, Jinseu Park   +4 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats [PDF]

, 2016
BACKGROUND: Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking.
Jun Cai, Na Guo, Wanling Gao, Weifeng Yao, Xinjin Chi, Yi Jin, Ziqing Hei   +6 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source