Results 71 to 80 of about 465,102 (291)

Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection [PDF]

, 2013
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of
Algood, Appelberg, Appelberg, Behar, Bullen, Castro, Chen, Converse, Cooper, Cooper, Davis, Divangahi, Duan, Fairbairn, Ferreira, Fortes, Gao, Gomes, Gomes, Gomes-Pereira, Gozzelino, Gozzelino, Ha, Haimovich, J. L. Flynn, Johnson, Johnson, Kovtunovych, Kumar, Labbe, Larsen, Lounis, Lousada, Lu, Maria Salomé Gomes, Medzhitov, Miguel Parreira Soares, Mitlyng, Paige, Pais, Pamplona, Pfaffl, Rao, Rasmus Larsen, Regev, Rodrigues, Roque, Rui Appelberg, Russell, Russell, Rustad, Sandro Silva-Gomes, Saunders, Saunders, Saunders, Schaible, Seixas, Shiloh, Silva, Soares, Tenhunen, Torrance, Ulrichs, Vandenabeele, Vanlangenakker, Vile, Walzl, Yet   +67 more
core   +2 more sources

SYNTHESIS OF FERRITE NANOPARTICLES WITH PROTEIN MOLECULES IMMOBILLIZED ON THEIR SURFACES

ASEAN Journal on Science and Technology for Development, 2017
The ferrite (a Fe3O4 – gFe2O3 mixed solution) fine particles, ~8 nm in size were synthesized from an aqueous solution. Trypsin, a proteolytic enzyme or a protein, was immobilized onto the surfaces of those particles during the synthesis process.
Tran Hoang Hai, Le Hong Phuc, Doan Thi Kim Dung, Nguyen Thi Le Huyen, Bui Duc Long, Nguyen Tien Thang, Vu Van Do, Nguyen Thi Nhu Quynh, Masanori Abe   +8 more
doaj   +1 more source

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling [PDF]

, 2018
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen.
A Arfe, A Bauer, A Kardosh, A Salminen, AJ Shaywitz, B Fisslthaler, BR Gunter, C Liu, C Mo, C Patrono, CC Thornton, CH He, D Carling, DH Solomon, DM Thomson, EH Kobayashi, EL Fosbol, FY Li, H Mylroie, HP Lin, HT Cheng, I Tegeder, IE Schauer, J Lindhardsen, J Steffel, JA Mitchell, JM Cacicedo, JS Wang, K Iwasaki, K Zimmermann, LC Wu, ME Widlansky, MP Seldon, MP Soares, MT Nurmohamed, N Bhala, NJ Goodson, NM Davies, NM Davies, P Kale, PA Watson, R Chenevard, R Gozzelino, RS Bresalier, S Jacob, S Trelle, SE Nissen, SK Paulson, SK Paulson, SL Colombo, SS Hamdulay, SS Hamdulay, SW Ryter, TD Penning, TM MacDonald, VL King, WB White, X Liu, XM Liu, Y Hattori, ZQ Zou   +60 more
core   +4 more sources

Dysiarenone from Marine Sponge Dysidea arenaria Attenuates ROS and Inflammation via Inhibition of 5-LOX/NF-κB/MAPKs and Upregulation of Nrf-2/OH-1 in RAW 264.7 Macrophages

Journal of Inflammation Research, 2021
Tian-Yong Hu,1,* Hua Zhang,1,* Yan-Yan Chen,1 Wei-Hua Jiao,2 Jun-Ting Fan,3 Zhi-Qiang Liu,1 Hou-Wen Lin,2 Bao-Hui Cheng1 1Shenzhen Key Laboratory of ENT, Institute of ENT and Longgang ENT Hospital, Shenzhen, 518172, People’s Republic of China ...
Hu TY, Zhang H, Chen YY, Jiao WH, Fan JT, Liu ZQ, Lin HW, Cheng BH   +7 more
doaj  

Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy

Experimental Gerontology, 2023
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degradation. At the histological level, it is mainly characterized by a reduction in muscle mass and fiber cross-sectional area (CSA ...
Qin Xiao, Chen-Chen Sun, Chang-Fa Tang
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats [PDF]

, 2013
One important concern in the treatment of diabetes is the maintenance of glycemic levels and the prevention of diabetic nephropathy. Inducible heme oxygenase 1 (HO-1) is a rate-limiting enzyme thought to have antioxidant and cytoprotective roles.
Albertoni, Guilherme A., Borges, Fernanda T., Convento, Marcia B., Fernandes, Gabryelle S., Pessoa, Edson A., Ptilovanciv, Ellen O. N., Reis, Luciana A., Schor, Nestor, Simoes, Manuel J., Teixeira, Luciana C.   +9 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures [PDF]

, 1964
Heme oxygenase-1 (HO-1) has been strongly highlighted because of its induction in many cell types by toxic stimuli, including oxidative stress. The intense HO-1 immunostaining in the substantia nigra of Parkinson disease (PD) patients suggests its ...
Saavedra, Ana, Baltazar, Graça, Carvalho, Caetana M., Duarte, Emília P.   +3 more
core  

Ischaemic post-conditioning protects lung from ischaemia-reperfusion injury by up-regulation of haeme oxygenase-1 [PDF]

, 2010
Objective: The emergence of ischaemic post-conditioning (IPO) provides a potential method for experimentally and clinically attenuating various types of organ injuries.
Ancharaz, AK, Gao, J, Liu, Kx, Luo, T, Xia, Z, Xia, Zy   +5 more
core   +1 more source