Results 61 to 70 of about 465,102 (291)

The Nrf2-HO-1 system and inflammaging

Frontiers in Immunology
Nrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1-induced heme catabolism have well established antioxidant and anti-inflammatory properties.
Sinead A. O’Rourke, Sinead A. O’Rourke, Lianne C. Shanley, Lianne C. Shanley, Aisling Dunne, Aisling Dunne, Aisling Dunne   +6 more
openaire   +3 more sources

HO‐1 promoter polymorphism associated with rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 2007
AbstractObjectiveTo investigate the role of the HO‐1 gene as a novel functional candidate gene for rheumatoid arthritis (RA).MethodsWe performed a case–control study including 736 RA patients and 846 healthy controls of Spanish Caucasian origin. Two putative functional HO‐1 promoter polymorphisms, a (GT)n microsatellite and a −413 A/T single‐nucleotide
Blanca, Rueda, Javier, Oliver, Gema, Robledo, Miguel A, López-Nevot, Alejandro, Balsa, Dora, Pascual-Salcedo, Miguel A, González-Gay, Maria F, González-Escribano, Javier, Martín   +8 more
openaire   +2 more sources

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Molecular Medicine Reports, 2021
Heme oxygenase‑1 (HO‑1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin. These degradation products serve an important role in the regulation of inflammation, oxidative stress and apoptosis. While the expression level of HO‑1 is typically low in most
Ma, Lin-Lin, Sun, Lei, Wang, Yu-Xi, Sun, Bai-He, Li, Yan-Fei, Jin, Yue-Ling   +5 more
openaire   +3 more sources

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Cardiovascular Mechanisms of Action of Anthocyanins May Be Associated with the Impact of Microbial Metabolites on Heme Oxygenase-1 in Vascular Smooth Muscle Cells [PDF]

, 2018
Anthocyanins are reported to have cardio-protective effects, although their mechanisms of action remain elusive. We aimed to explore the effects of microbial metabolites common to anthocyanins and other flavonoids on vascular smooth muscle heme oxygenase-
Kay, Colin D, O'Connell, Maria A, Rodriguez-Ramiro, Ildefonso, Warner, Emily F   +3 more
core   +2 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Plasma Heme Oxygenase-1 Concentration is Elevated in Individuals with Type 2 Diabetes Mellitus [PDF]

, 2012
Background: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes ...
Bao, Wei, Hao, Liping, Hu, Frank B., Li, Xiangyang, Liu, Liegang, Rong, Shuang, Song, Fangfang, Yang, Nianhong, Yang, Wei, Yao, Ping, Zhang, Muxun   +10 more
core   +1 more source

Mitochondrial quality-control dysregulation in conditional HO-1–/– mice [PDF]

JCI Insight, 2017
The heme oxygenase-1 (Hmox1; HO-1) pathway was tested for defense of mitochondrial quality control in cardiomyocyte-specific Hmox1 KO mice (HO-1[CM]-/-) exposed to oxidative stress (100% O2). After 48 hours of exposure, these mice showed persistent cardiac inflammation and oxidative tissue damage that caused sarcomeric disruption, cardiomyocyte death ...
Hagir B, Suliman, Jeffrey E, Keenan, Claude A, Piantadosi   +2 more
openaire   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Regulation of T cell responses by Heme Oxygenase-1 [PDF]

, 2008
Tese de mestrado, Biologia (Biologia Molecular e Genética), 2008, Universidade de Lisboa, Faculdade de CiênciasMultiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system (CNS).
Cortez, Eliane Cristina Monteiro
core