Results 111 to 120 of about 456,511 (292)

Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection [PDF]

, 2013
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of
Algood, Appelberg, Appelberg, Behar, Bullen, Castro, Chen, Converse, Cooper, Cooper, Davis, Divangahi, Duan, Fairbairn, Ferreira, Fortes, Gao, Gomes, Gomes, Gomes-Pereira, Gozzelino, Gozzelino, Ha, Haimovich, J. L. Flynn, Johnson, Johnson, Kovtunovych, Kumar, Labbe, Larsen, Lounis, Lousada, Lu, Maria Salomé Gomes, Medzhitov, Miguel Parreira Soares, Mitlyng, Paige, Pais, Pamplona, Pfaffl, Rao, Rasmus Larsen, Regev, Rodrigues, Roque, Rui Appelberg, Russell, Russell, Rustad, Sandro Silva-Gomes, Saunders, Saunders, Saunders, Schaible, Seixas, Shiloh, Silva, Soares, Tenhunen, Torrance, Ulrichs, Vandenabeele, Vanlangenakker, Vile, Walzl, Yet   +67 more
core   +2 more sources

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury [PDF]

, 2013
The activation of heme oxygenase-1 (HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catabolizes heme into carbon monoxide (CO)
Câmara, Niels Olsen Saraiva, Origassa, Clarice Silvia Taemi   +1 more
core   +1 more source

Research on a flow-mode magneto-rheological impact damper with stroke-activated capability

Vietnam Journal of Mechanics
It is widely recognized that impact is an intricate problem that has challenged scientific scholars for many years. Impacts, such as those occurring in high-speed aircraft landings, vehicle accidents, or machine tool operations, pose substantial hazards
Huu-Quan Nguyen, Quoc-Duy Bui, Duc-Nam Nguyen, Quoc Hung Nguyen, Long-Vuong Hoang   +4 more
doaj   +1 more source

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source

Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation [PDF]

, 2015
Scope Vascular smooth muscle cell (VSMC) proliferation is involved in the pathogenesis of cardiovascular disease, making the identification of new counteracting agents and their mechanisms of action relevant.
Andreas Schinkovitz, Atanas G. Atanasov, Barbara Gröblacher, Dean Guo, Elke H. Heiss, Franz Bucar, Nadine Sider, R. China, Rongxia Liu, Rudolf Bauer, Verena M. Dirsch   +10 more
core   +4 more sources

Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway [Retraction]

International Journal of Nanomedicine, 2022
Li P, Bukhari SNA, Khan T, et al. Int J Nanomedicine. 2020;15:9115–9124. The Editor and Publisher of International Journal of Nanomedicine wish to retract the published article.
Li P, Bukhari SNA, Khan T, Chitti R, Bevoor DB, Hiremath AR, SreeHarsha N, Singh Y, Gubbiyappa KS   +8 more
doaj  

Protective role of HO-1 in oxidative tissue injuries

Folia Pharmacologica Japonica, 2007
昨今の生命科学の進歩は薬理学の研究をより病態に応じた新薬の開発へと向かわせている．しかし，肝不全，腎不全，多臓器不全など，急性臓器不全は高い死亡率を示すにもかかわらず，その治療において決め手となる薬物は未だ開発されていない．これら急性臓器不全の組織障害の病態生理は完全に明らかでないが，好中球の活性化や虚血・再潅流にともなう酸化ストレスによる細胞傷害が大きな役割を果たしている．酸化ストレスはヘムタンパク質からヘムを遊離させる．遊離ヘムは脂溶性の鉄であることから，活性酸素生成を促進して細胞傷害を悪化させる．この侵襲に対抗するために，ヘム分解の律速酵素：Heme Oxygenase-1（HO-1）が細胞内に誘導される．HO-1によるヘム分解反応産物である一酸化炭素，胆汁色素には，抗炎症・抗酸化作用がある ...
Toru, Takahashi, Hiroko, Shimizu, Kazuyoshi, Inoue, Hiroshi, Morimatsu, Kana, Umeda, Emiko, Omori, Reiko, Akagi, Kiyoshi, Morita   +7 more
openaire   +3 more sources

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Protective role of H2S on acute renal damages in urinary-derived sepsis

Biotechnology & Biotechnological Equipment, 2019
The aim of this study was to investigate the protective roles of H2S on acute renal damage in urinary-derived sepsis. Totally 40 male rabbits were randomly divided into the Control, Sham, Sepsis, NaHS and the dl-propargylglycine (PAG) groups. White blood
Wujun Xu, Yachun Tang, Xiaofeng Zhao, Liwen Zhao, Xiaobin Wu, Li Liu, Xiangyang Long, Zhigang Luo, Xian Chen, Binhui Wang   +9 more
doaj   +1 more source