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Cationic host defense (antimicrobial) peptides
Current Opinion in Immunology, 2006Members of the cationic host defense (antimicrobial) peptide family are widely distributed in nature, existing in organisms from insects to plants to mammals and non-mammalian vertebrates. Although many demonstrate direct antimicrobial activity against bacteria, fungi, eukaryotic parasites and/or viruses, it has been established that cationic peptides ...
Kelly L, Brown, Robert E W, Hancock
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Host defense peptides in burns
Burns, 2004Overuse of antibiotics and failure to apply basic infection control policies and procedures have contributed to the increasing multi-drug resistance of many nosocomial pathogens. The alarming increase of multi-drug-resistant bacteria (e.g. Pseudomonas aeruginosa, methicilin-resistant Staphylococci, vancomycin-resistant Enterococci) causes infected ...
L, Steinstraesser +3 more
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Host defense peptides: front-line immunomodulators
Trends in Immunology, 2014Although first studied for their antimicrobial activity, host defense peptides (HDPs) are now widely recognized for their multifunctional roles in both the innate and adaptive immune responses. Their diverse immunomodulatory capabilities include the modulation of pro- and anti-inflammatory responses, chemoattraction, enhancement of extracellular and ...
Sarah C, Mansour +2 more
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Natural History of Innate Host Defense Peptides
Probiotics and Antimicrobial Proteins, 2009Host defense peptides act on the forefront of innate immunity, thus playing a central role in the survival of animals and plants. Despite vast morphological changes in species through evolutionary history, all animals examined to date share common features in their innate immune defense strategies, hereunder expression of host defense peptides (HDPs ...
A, Linde +7 more
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Antifungal Host Defense Peptides
2016Fungi infect billions of people every year, yet their contribution to the global burden of disease is largely unrecognized and the repertoire of antifungal agents is rather limited. Thus, treatment of life-threatening invasive fungal infections is still based on drugs discovered several decades ago.
Karl Lohner, Regina Leber
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Transcriptional Regulation of Antimicrobial Host Defense Peptides
Current Protein & Peptide Science, 2015Host defense peptides (HDPs) are of either myeloid or epithelial origin with antimicrobial and immunomodulatory functions. Due to HDP's ability to physically disrupt bacterial cell membranes and profoundly regulate host innate and adaptive immunity, microbial resistance to these peptides is rare.
Wentao, Lyu +3 more
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Bacterial resistance mechanisms against host defense peptides
Cellular and Molecular Life Sciences, 2011Host defense peptides and proteins are important components of the innate host defense against pathogenic microorganisms. They target negatively charged bacterial surfaces and disrupt microbial cytoplasmic membranes, which ultimately leads to bacterial destruction.
Tomaz, Koprivnjak, Andreas, Peschel
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Host Defense Peptides in the Oral Cavity
2008Publisher Summary Host defense peptides (HDPs) are important in defense of tissues throughout the human mouth. Like resident microbial populations, HDPs are diverse, species-specific, and site-specific, and they have evolved in response to selection pressures exerted by resident and pathogenic microbial populations.
Deirdre A, Devine, Celine, Cosseau
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Potential Therapeutic Application of Host Defense Peptides
2009Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines.
Lijuan, Zhang, Timothy J, Falla
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Porcine host defense peptides: Expanding repertoire and functions
Developmental & Comparative Immunology, 2009Host defense peptides (HDPs) are a large group of innate immune effectors that are also termed antimicrobial peptides. Because of the rapid progress that has been made in completing several animal genomes, many HDPs have been systemically defined using bioinformatic analysis and partially characterized using reverse genomic approaches.
Yongming, Sang, Frank, Blecha
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