Results 51 to 60 of about 713,544 (377)

Stochastic spatial models of host-pathogen and host-mutualist interactions I

, 2006
Mutualists and pathogens, collectively called symbionts, are ubiquitous in plant communities. While some symbionts are highly host-specific, others associate with multiple hosts.
Lanchier, N., Neuhauser, C.
core   +2 more sources

Signatures of Pleiotropy, Economy and Convergent Evolution in a Domain-Resolved Map of Human–Virus Protein–Protein Interaction Networks [PDF]

, 2013
A central challenge in host-pathogen systems biology is the elucidation of general, systems-level principles that distinguish host-pathogen interactions from within-host interactions.
Franzosa, Eric A., Garamszegi, Sara, Xia, Yu   +2 more
core   +2 more sources

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit

Nature Communications, 2018
SAMHD1 is a critical restriction factor for HIV-1 and its antiviral activity is regulated by T592 phosphorylation. Here, Schott et al. show that the phosphatase PP2A-B55α dephosphorylates SAMHD1 during mitotic exit, rendering it antivirally active in G1 ...
Kerstin Schott, Nina V. Fuchs, Rita Derua, Bijan Mahboubi, Esther Schnellbächer, Janna Seifried, Christiane Tondera, Heike Schmitz, Caitlin Shepard, Alberto Brandariz-Nuñez, Felipe Diaz-Griffero, Andreas Reuter, Baek Kim, Veerle Janssens, Renate König   +14 more
doaj   +1 more source

Characterising within-hospitalSARS-CoV-2 transmission events using epidemiological and viral genomic data across two pandemic waves

Nature Communications, 2022
SARS-CoV-2 has resulted in multiple outbreaks in hospitals, but identifying transmission events is challenging. Here, the authors combine whole genome sequencing and epidemiological data from the first two waves of the pandemic at a UK hospital trust and
Benjamin B. Lindsey, Ch. Julián Villabona-Arenas, Finlay Campbell, Alexander J. Keeley, Matthew D. Parker, Dhruv R. Shah, Helena Parsons, Peijun Zhang, Nishchay Kakkar, Marta Gallis, Benjamin H. Foulkes, Paige Wolverson, Stavroula F. Louka, Stella Christou, Amy State, Katie Johnson, Mohammad Raza, Sharon Hsu, Thibaut Jombart, Anne Cori, Sheffield COVID-19 Genomics Group, The COVID-19 Genomics UK (COG-UK) consortium, CMMID COVID-19 working group, Cariad M. Evans, David G. Partridge, Katherine E. Atkins, Stéphane Hué, Thushan I. de Silva   +27 more
doaj   +1 more source

Molecular surveillance of Cryptosporidium spp. for microbial source tracking of fecal contamination in Laguna Lake, Philippines

Journal of Water and Health, 2021
Water quality deterioration in source waters poses increased health, environmental, and economic risks. Here, we genotyped Cryptosporidium spp. obtained from water samples of Laguna Lake, Philippines, and its tributaries for the purpose of source ...
Laurice Beatrice Raphaelle O. dela Peña, Mark Raymond A. Vejano, Windell L. Rivera   +2 more
doaj   +1 more source

Exploring NAD(+) metabolism in host-pathogen interactions [PDF]

, 2016
Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells. NAD+ intracellular levels are dictated by its synthesis, using the de novo and/or salvage pathway, and through its catabolic use as co-enzyme or co-substrate.
Belinha, Ana, Gaifem, Joana, Mesquita, Inês Morais, Silvestre, Ricardo Jorge Leal   +3 more
core   +1 more source

Dominant couplings in qubit networks with controlled interactions [PDF]

J. Phys. A: Math. Theor. 48 215301 (2015), 2015
Systems evolving under the influence of competing two-body and three-body interactions, are of particular interest in exploring the stability of equilibrium states of strongly interacting many-body system. We present a solvable model based on qubit networks, which allows us to investigate the intricate influence of these couplings on the possible ...
arxiv   +1 more source

Artificial intelligence and neoantigens: paving the path for precision cancer immunotherapy

Frontiers in Immunology
Cancer immunotherapy has witnessed rapid advancement in recent years, with a particular focus on neoantigens as promising targets for personalized treatments.
Alla Bulashevska, Zsófia Nacsa, Franziska Lang, Markus Braun, Martin Machyna, Mustafa Diken, Liam Childs, Renate König   +7 more
doaj   +1 more source

AMPK in Pathogens [PDF]

, 2016
During host–pathogen interactions, a complex web of events is crucial for the outcome of infection. Pathogen recognition triggers powerful cellular signaling events that is translated into the induction and maintenance of innate and adaptive host ...
A Acosta-Serrano, A Barquilla, A Barquilla, A Bonen, A Crawford, A Schubert-Unkmeir, A Singhal, A Street, A Woods, A Woods, AC Ferretti, AJ Hoogendijk, AK Pandey, AS Marsin, B Hurtrel, B Kelly, B Levine, B Sampaio-Marques, B Xiao, BF Holmes, BM Mony, BM Mony, C Bermejo, C Hutterer, C Polge, CB Ramsook, CE Moseley, CM Hull, CS Clemmens, CS Yang, CW Ong, CY Park, D Bumann, D Ghosh, D Kumar, D Miranda-Saavedra, D Moreira, D Sag, D Yang, DA Escobar, DE Levin, DF Egan, DG Hardie, DG Hardie, DM Shin, DW Park, E Gjini, E Rey-Jurado, E Vassella, EB Gordon, EJ Munoz-Elias, EM Al-Olayan, F Estruch, F Nagajyothi, F Navarro-Garcia, F Rousset, G Hu, G Lv, G Zandbergen van, G Zhou, GP Meares, H Huang, H Zangger, H Zhao, HC Ng, HC Ng, HJ Flint, HS Kwon, HS Zhang, HS Zhang, I Rabhi, I Tattoli, J Blagih, J Blagih, J Brunton, J Daniel, J Daniel, J Estaquier, J Estaquier, J Estaquier, J Kim, J Kim, J Mankouri, J McArdle, J McArdle, J Rolf, J Yang, J Yang, JC Ameisen, JD Artz, JD Burke, JD McKinney, JI MacRae, JJ Kim, JL Celenza, JL Celenza, JL Celenza, JM Brenchley, JM Gancedo, JM Yuk, JR Forbes, JV Li, JW Yu, JY Seo, K Ashrafi, K Barnes, K Hedbacker, K Inoki, K Moreau, K Nakashima, K Tsoyi, K Vickerman, K Yang, KL Buchanan, KL Caradonna, KM Jeong, KY Kang, KY Rhee, L Campillo-Gimenez, L Chantranupong, L Francione, LC Pollitt, LG Tilney, LJ Terry, M Carlson, M Cemma, M Fulco, M Parsons, M Raffatellu, M Romero-Gomez, MA Horwitz, MC Cumont, MC Lorenz, MI Hood, MR Gonzalez, MT Sorbara, N Kloft, NJ MacIver, O Vincent, P Sanz, R Appelberg, R Mehla, R Petter, R Petter, R Plummer, R Santarelli, R Tewari, RD Adam, RJ Shaw, S Chakrabarti, S Hohmann, S Horman, S Kuchin, S Pagans, S Steele, SA Hawley, SA Hawley, SB Kudchodkar, SC Stein, SE Reece, SH Kumar, SM Landfear, SR Waterman, T Naderer, TG Mitchell, TS Moser, TS Moser, V Bracchi, V Cecchinato, V Deretic, V Monceaux, W Lee, WT Ji, WW Winder, Y Abu Kwaik, Y Guo, Y Tang, Y Wang, YW Kim, Z Yang, Z Zhang, Z Zhao   +181 more
core   +3 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source