Results 81 to 90 of about 871,394 (166)

Bioactive Molecules of Microalgae Haematococcus pluvialis–Mediated Synthesized Silver Nanoparticles: Antioxidant, Antimicrobial, Antibiofilm, Hemolysis Assay, and Anticancer

Bioinorganic Chemistry and Applications, Volume 2025, Issue 1, 2025.
Bioactive molecule‐based synthesis of silver nanoparticles (AgNPs) offers an eco‐friendly approach with high therapeutic potential; however, research in this area remains limited. This study introduces hot melt extrusion (HME) technology to enhance the extraction efficiency of bioactive compounds, including astaxanthin, from the microalgae ...
Yoo-Na Jeon, Su-Ji Ryu, Anbazhagan Sathiyaseelan, Jong-Suep Baek, Guillermo Mendoza-Diaz   +4 more
wiley   +1 more source

Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Angelica gigas Nakai

Bioinorganic Chemistry and Applications, 2020
Angelica gigas Nakai (AGN) was first processed by ultrafine grinding technology and hot-melt extrusion (HME). The potential antioxidant and anti-inflammatory activities of AGN with a different process were compared, and the effect on the human Kv1.3 ...
Yunyao Jiang, Jingpei Piao, Nan Liu, Jincai Hou, Jianxun Liu, Weicheng Hu   +5 more
doaj   +1 more source

Hot-melt extrusion technology and pharmaceutical application

, 2012
The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to its proven ability to efficiently manufacture novel products.
Wilson, M., Williams, M.A., Jones, D.S., Andrews, G.P.   +3 more
core   +1 more source

Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid

Asian Journal of Pharmaceutical Sciences, 2017
The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid (OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion (HME) was applied to develop OA amorphous solid dispersions.
Nannan Gao, Mengran Guo, Qiang Fu, Zhonggui He   +3 more
doaj   +1 more source

Production of amorphous solid dispersions to circumvent drugs’ poor water solubility problems with mature hot-melt extrusion and innovative 3D printing technology

, 2022
The number of drugs with solubility constraints under development has been increasing, impacting the oral bioavailability, and leading to major challenges in the development of oral dosage forms. To circumvent this problem various strategies can be used,
Macedo, Joana
core  

Optimising Extrusion-based Pla-asa 3D Printed Drug Delivery Mesh Using Pat Tools

Chemical Engineering Transactions
In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined.
Yazan Odeh, Debleena Mitra, Mohammad O. A. Malik, Douglas R. Marques, Rabah Mouras, Marion Mcafee   +5 more
doaj  

Improving the Solubility of Formononetin and Enabling Hydrogel-Based Wound-Oriented Applications Through the Effect of Hot-Melt Extrusion

Applied Sciences
Isoflavones are plant-derived polyphenols with broad biological activity; however, their application in topical formulations is limited by poor aqueous solubility.
Anna Gościniak, Natalia Rosiak, Miłosz Ignacyk, Barbara Kaproń-Plech, Piotr Trzaskoma, Bozena Michniak-Kohn, Judyta Cielecka-Piontek   +6 more
doaj   +1 more source

Preparation and Evaluation of Inhalable Microparticles with Improved Aerodynamic Performance and Dispersibility Using L-Leucine and Hot-Melt Extrusion

Pharmaceutics
Dry-powder inhalers (DPIs) are valued for their stability but formulating them is challenging due to powder aggregation and limited flowability, which affects drug delivery and uniformity. In this study, the incorporation of L-leucine (LEU) into hot-melt
Jin-Hyuk Jeong, Ji-Su Kim, Yu-Rim Choi, Dae Hwan Shin, Ji-Hyun Kang, Dong-Wook Kim, Yun-Sang Park, Chun-Woong Park   +7 more
doaj   +1 more source

Revolutionizing Personalized Medicine: 3D-Printed Drug Dosage Forms via Hot Melt Extrusion [PDF]

Recent advancements in pharmaceutical manufacturing are paving the way for highly personalized and on-demand therapies. This article discusses a novel approach that integrates Hot Melt Extrusion (HME) with 3D printing to produce drug dosage forms with ...
Arora , Pooja, Kumar, Amit
core   +1 more source

An alternative filament fabrication method as the basis for 3D-printing personalized implants from elastic ethylene vinyl acetate copolymer

Scientific Reports
In this work, a novel tool for small-scale filament production is presented. Unlike traditional methods such as hot melt extrusion (HME), the device (i) allows filament manufacturing from small material amounts as low as three grams, (ii) ensures high ...
Bianca Brandl, Simone Eder, Andreas Hirtler, Gloria Khinast, Jeffrey Haley, Christian Schneider, Samuel Theissl, Andreas Bramboeck, Daniel Treffer, Sarah Heupl, Martin Spoerk   +10 more
doaj   +1 more source