Results 81 to 90 of about 924,399 (169)

IMPROVING SOLUBILITY AND DISSOLUTION OF A NATURAL PRODUCT APIGENIN VIA PREPARATION OF SOLID DISPERSION BY HOT MELT EXTRUSION [PDF]

, 2021
Objective: Hot Melt Extrusion (HME) is one of the techniques for preparing a solid dispersion hydrophilic excipient known as a no solvents practical method to increase the solubility of drugs.
SUBARNAS, ANAS, STIANI, SOFI N., RUSDIANA, TAOFIK   +2 more
core   +1 more source

Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion - II: Cellulosic polymers [PDF]

, 2016
The purpose of this study was to determine the thermal and viscoelastic properties of cellulosic polymers that may have potential for use in hot melt extrusion (HME). Cellulose ethers of different molecular weight (MW) with varied degrees of substitution
Simerdeep Singh Gupta, Abu T.M. Serajuddin, Anuprabha Meena, Tapan Parikh   +3 more
core  

Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid

Asian Journal of Pharmaceutical Sciences, 2017
The aim of this study was to improve the in vitro dissolution rate and oral bioavailability of oleanolic acid (OA), a water insoluble drug belonging to BCS class IV. Hot melt extrusion (HME) was applied to develop OA amorphous solid dispersions.
Nannan Gao, Mengran Guo, Qiang Fu, Zhonggui He   +3 more
doaj   +1 more source

Optimising Extrusion-based Pla-asa 3D Printed Drug Delivery Mesh Using Pat Tools

Chemical Engineering Transactions
In this study, the use of extrusion-based 3D printing for the fabrication of a personalized drug delivery Polylactic acid (PLA) – Aspirin (ASA) mesh for bone tissue engineering is examined.
Yazan Odeh, Debleena Mitra, Mohammad O. A. Malik, Douglas R. Marques, Rabah Mouras, Marion Mcafee   +5 more
doaj  

Improving the Solubility of Formononetin and Enabling Hydrogel-Based Wound-Oriented Applications Through the Effect of Hot-Melt Extrusion

Applied Sciences
Isoflavones are plant-derived polyphenols with broad biological activity; however, their application in topical formulations is limited by poor aqueous solubility.
Anna Gościniak, Natalia Rosiak, Miłosz Ignacyk, Barbara Kaproń-Plech, Piotr Trzaskoma, Bozena Michniak-Kohn, Judyta Cielecka-Piontek   +6 more
doaj   +1 more source

Preparation and Evaluation of Inhalable Microparticles with Improved Aerodynamic Performance and Dispersibility Using L-Leucine and Hot-Melt Extrusion

Pharmaceutics
Dry-powder inhalers (DPIs) are valued for their stability but formulating them is challenging due to powder aggregation and limited flowability, which affects drug delivery and uniformity. In this study, the incorporation of L-leucine (LEU) into hot-melt
Jin-Hyuk Jeong, Ji-Su Kim, Yu-Rim Choi, Dae Hwan Shin, Ji-Hyun Kang, Dong-Wook Kim, Yun-Sang Park, Chun-Woong Park   +7 more
doaj   +1 more source

Model-based formulation of amorphous solid dispersions made by hot-melt extrusion [PDF]

, 2019
Regarding hot-melt extrusion in early pharmaceutical formulation and process development, techniques and procedures are needed to simplify the application of hot-melt extrusion (HME) and to decrease the effort in terms of material and time.
Bochmann, Esther Sophia
core   +1 more source

An alternative filament fabrication method as the basis for 3D-printing personalized implants from elastic ethylene vinyl acetate copolymer

Scientific Reports
In this work, a novel tool for small-scale filament production is presented. Unlike traditional methods such as hot melt extrusion (HME), the device (i) allows filament manufacturing from small material amounts as low as three grams, (ii) ensures high ...
Bianca Brandl, Simone Eder, Andreas Hirtler, Gloria Khinast, Jeffrey Haley, Christian Schneider, Samuel Theissl, Andreas Bramboeck, Daniel Treffer, Sarah Heupl, Martin Spoerk   +10 more
doaj   +1 more source

Material-Sparing Feasibility Screening for Hot Melt Extrusion

Pharmaceutics
Hot melt extrusion (HME) offers a high-throughput process to manufacture amorphous solid dispersions. A variety of experimental and model-based approaches exist to predict API solubility in polymer melts, but these methods are typically aimed at ...
Amanda Pluntze, Scott Beecher, Maria Anderson, Dillon Wright, Deanna Mudie   +4 more
doaj   +1 more source

Enhancing the bioavailability of hydrophobic drugs using hot melt extrusion [PDF]

, 2018
Many existing drugs (as well as new revelations) in the pharmaceutical industry bear a distinct disadvantage in the sense that they are not water soluble, displaying low bioavailability values and consequently a reduced invitro effect. Hot melt extrusion
Coffey, Conor, Higginbotham, Clement, Geever, Luke M., Devine, Declan M.   +3 more
core   +1 more source