Results 71 to 80 of about 924,399 (169)

Hot-melt extrusion: process to novel pharmaceutical applications

, 2013
Over the last three decades industrial adaptability has allowed hot-melt extrusion (HME) to gain wide acceptance and has already established its place in the broad spectrum of manufacturing operations and pharmaceutical research development.
Mohammed Maniruzzaman (1626004)
core   +1 more source

Quality by Design (QbD) Approach to Develop Colon-Specific Ketoprofen Hot-Melt Extruded Pellets: Impact of Eudragit^® S 100 Coating on the In Vitro Drug Release

Pharmaceutics
Background: A pelletizer paired with hot-melt extrusion technology (HME) was used to develop colon-targeted pellets for ketoprofen (KTP). Thermal stability and side effects in the upper gastrointestinal tract made ketoprofen more suitable for this work ...
Sateesh Kumar Vemula, Sagar Narala, Prateek Uttreja, Nagarjuna Narala, Bhaskar Daravath, Chamundeswara Srinivasa Akash Kalla, Srikanth Baisa, Siva Ram Munnangi, Naveen Chella, Michael A. Repka   +9 more
doaj   +1 more source

Regulatory Guidelines for the Analysis of Therapeutic Peptides and Proteins

Journal of Peptide Science, Volume 31, Issue 3, March 2025.
Guidelines from regulatory agencies support the analysis and quality control of peptide and protein drugs. Key aspects of the analysis process are summarized here. ABSTRACT Peptides and proteins have become increasingly important in the treatment of various diseases, including infections, metabolic disorders, and cancers.
Yomnah Y. Elsayed, Toni Kühl, Diana Imhof   +2 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Influence of Carbon Dioxide on the Phase Behavior of Pharmaceutical Drug‐Polymer Dispersions

Macromolecular Chemistry and Physics, Volume 226, Issue 2, January 2025.
Amorphous solid dispersion formulations tackle oral delivery challenges for poorly soluble drugs by embedding them in soluble carrier polymers. High‐pressure differential scanning calorimetry reveals the influence of carbon dioxide on drug‐polymer phase behavior.
Jana Klueppelberg, Ulrich A. Handge, Markus Thommes, Judith Winck   +3 more
wiley   +1 more source

Effect of Ultrafine Powderization and Solid Dispersion Formation via Hot-Melt Extrusion on Antioxidant, Anti-Inflammatory, and the Human Kv1.3 Channel Inhibitory Activities of Angelica gigas Nakai

Bioinorganic Chemistry and Applications, 2020
Angelica gigas Nakai (AGN) was first processed by ultrafine grinding technology and hot-melt extrusion (HME). The potential antioxidant and anti-inflammatory activities of AGN with a different process were compared, and the effect on the human Kv1.3 ...
Yunyao Jiang, Jingpei Piao, Nan Liu, Jincai Hou, Jianxun Liu, Weicheng Hu   +5 more
doaj   +1 more source

Fabrication of Intragastric Floating, Controlled Release 3D Printed Theophylline Tablets Using Hot-Melt Extrusion and Fused Deposition Modeling

Pharmaceutics, 2020
This work presents a novel approach for producing gastro-retentive floating tablets (GRFT) by coupling hot-melt extrusion (HME) and fused deposition three-dimensional printing (3DP).
Bhupendra Raj Giri, Eon Soo Song, Jaewook Kwon, Ju-Hyun Lee, Jun-Bom Park, Dong Wuk Kim   +5 more
doaj   +1 more source

Folic Acid–Functionalized MWCNT‐Conjugated Zirconium Oxide Nanoparticles for Targeted Cancer Cell Delivery of Astaxanthin

Bioinorganic Chemistry and Applications, Volume 2025, Issue 1, 2025.
In this study, zirconium oxide nanoparticles (ZrO2 NPs) were synthesized using astaxanthin (AST) rich extract (AZ) and subsequently conjugated with multiwalled carbon nanotubes (MWCNTs) (AZM) and functionalized with folic acid (FA) (FAZM) to develop a cancer‐targeting nanocomposite with enhanced anticancer efficacy.
Han-Sol You, Anbazhagan Sathiyaseelan, Myeong-Hyeon Wang, Jong-Suep Baek, Giuseppe Ciccarella   +4 more
wiley   +1 more source

3D-printed Gabapentin-loaded Implants for Sustained Release: Leveraging 3D Printing and Hot Melt Extrusion (HME) for Customizable Drug Delivery

AAPS PharmSciTech
Abstract Pediatric neuropathy poses significant challenges in pain management due to the limited availability of approved pharmacological options. Gabapentin, commonly used for neuropathic pain, offers therapeutic potential but necessitates careful dosing due to its variable bioavailability. This study investigates the integration of Hot Melt
Baher A. Daihom, Hala M. Abdelhakk, Mohammed Maniruzzaman   +2 more
openaire   +2 more sources

Hot Melt Extrusion: A Viable Option for Implementing Continuous Manufacturing in the Pharmaceutical Industry [PDF]

In recent years, hot melt extrusion (HME) has been most widely investigated for developing pharmaceutical medications. HME is a single-step manufacturing process and is suitable for the extrusion of drug-loaded filaments, films, or patches, and granules.
Mannala, Tirupathi
core   +1 more source