Results 201 to 210 of about 20,895 (215)
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HSF1 Signaling Inhibits Apoptosis in Hepatoblastoma
The FASEB Journal, 2022Introduction Hepatoblastoma (HB) is the most common pediatric liver malignancy. While relatively rare, its incidence is increasing. Currently surgical resection with or without chemotherapy is the main treatment for the tumor though in severe cases children require liver transplantation. Development of precision
Edward Hurley +4 more
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HSF1 and Its Role in Huntington’s Disease Pathology
2022Heat shock factor 1 (HSF1) is the master transcriptional regulator of the heat shock response (HSR) in mammalian cells and is a critical element in maintaining protein homeostasis. HSF1 functions at the center of many physiological processes like embryogenesis, metabolism, immune response, aging, cancer, and neurodegeneration.
Hyuck, Kim, Rocio, Gomez-Pastor
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Redox signaling of cardiac HSF1 DNA binding
American Journal of Physiology-Cell Physiology, 2002Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein ( hsp) genes are the result of oxidation and/or depletion of ...
Zain, Paroo +5 more
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Toxicology and Applied Pharmacology, 2003
Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological ...
Wirth, D. +4 more
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Cadmium (Cd) is known to activate heat shock (HS) response, which is characterized by overexpression of heat shock proteins (Hsps) under the control of heat shock factor 1 (HSF1). The potential protection provided by the HS response, induced by increasing the body temperature of animals before Cd exposure or by Cd itself, against pathophysiological ...
Wirth, D. +4 more
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Hsf1 in Her2-positive Breast Cancer
2011Abstract : This study demonstrates that Hsf1 controls development of Her2-positive cancer both at the stage of initiation, via control of the oncogene-induced senescence, and progression, via regulation of tumor angiogenesis. It also dissects the mechanism of effects of Hsf1 on tumor angiogenesis, and demonstrates that Hsf1 regulates expression of the ...
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Linking HSF1 Activation to Translation
Science's STKE, 2006Cells can survive heat stress by increasing the abundance of heat shock proteins (HSPs) and other cytoprotective proteins to prevent toxicity from excess improperly folded proteins. In addition, heat shock inhibits translation and disrupts the cytoskeleton.
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The International Journal of Biochemistry & Cell Biology, 2017
Heat shock factor 1 (HSF1) critically contributes to the host defense, and its amount determines the mobilization efficiency of HSF1 under stress conditions. To date, how HSF1 amount is regulated remains largely unknown. We found that methylene blue (MB), an anti-oxidative and anti-inflammatory agent, increased the amount of HSF1 in BV-2 microglia ...
Chao, Huang +12 more
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Heat shock factor 1 (HSF1) critically contributes to the host defense, and its amount determines the mobilization efficiency of HSF1 under stress conditions. To date, how HSF1 amount is regulated remains largely unknown. We found that methylene blue (MB), an anti-oxidative and anti-inflammatory agent, increased the amount of HSF1 in BV-2 microglia ...
Chao, Huang +12 more
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Regulation of HSF1 protein stabilization: An updated review
European Journal of Pharmacology, 2018Heat shock factor 1 (HSF1) is a transcriptional factor that determines the efficiency of heat shock responses (HSRs) in the cell. Given its function has been extensively studied in recent years, HSF1 is considered a potential target for the treatment of disorders associated with protein aggregation.
Chao, Huang +5 more
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2007
Induction of hsp genes by heat and chemicals is strictly dependent on the presence in their non-transcribed regulatory sequences of so-called heat shock elements (abbreviated HSEs) (Mirault et al., 1982; Pelham, 1982). HSEs are arrays of three or more modules of the sequence element NGAAN (or AGAAN) or variations thereof (Amin et al., 1988; Xiao and ...
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Induction of hsp genes by heat and chemicals is strictly dependent on the presence in their non-transcribed regulatory sequences of so-called heat shock elements (abbreviated HSEs) (Mirault et al., 1982; Pelham, 1982). HSEs are arrays of three or more modules of the sequence element NGAAN (or AGAAN) or variations thereof (Amin et al., 1988; Xiao and ...
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Regulation of Hsf1 and the Heat Shock Response
2020The heat shock response (HSR) is characterized by the induction of molecular chaperones following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of genes controlled by the transcription factor Hsf1. The HSR is induced by defects in co-translational protein folding, ribosome biogenesis, organellar targeting of nascent ...
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