Results 161 to 170 of about 108,942 (214)

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Hypertension and Diabetes Cooperatively Drive HSP90 Activation, HSP70 Suppression, and Left Ventricular Interstitial Expansion: Relevance to Maladaptive Myocardial Remodeling. [PDF]

Pathophysiology
Sklifasovskaya AP, Blagonravov ML, Azova MM, Kurevlev SV, Goryachev VA, Syatkin SP, Zotova TY, Prokofiev DY.   +7 more
europepmc   +1 more source

From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Mitochondrial carrier proteins are essential for cellular physiology as they are active in a wide range of metabolic pathways including production of cellular energy, amino acid synthesis, redox balance and ion homeostasis. The double membrane of mitochondria provides a tightly gated environment through which carrier proteins facilitate the ...
Catherine S. Palmer, Phoebe J. Leeming, Diana Stojanovski   +2 more
wiley   +1 more source

Small-molecule PS10 inhibits PRRSV replication by targeting HSP90 and multiple viral non-structural proteins. [PDF]

J Virol
Chen Y, Wang J, Lu H, Chen Z, Huang B, Guo C.   +5 more
europepmc   +1 more source

Trematode infection buffers heat stress in blue mussels Mytilus edulis: The role of heat shock proteins

Journal of Animal Ecology, Volume 95, Issue 4, Page 648-657, April 2026.
The study shows that parasite infection changes heat shock protein expression and can increase heat tolerance in blue mussels. By separating parasite and temperature effects, the results suggest that infection may improve survival during heat stress, highlighting important parasite–host interactions for climate change resilience. Abstract The influence
Annika Greve, Jesper G. Sørensen, Mikael K. Sejr, Jakob Thyrring   +3 more
wiley   +1 more source

Heat Shock Protein 70 Deficient Mice Exhibit Reduced Psoriasis-like Skin Inflammation. [PDF]

Biomedicines
Kalantidou A, Kostakou M, Deiktakis M, Chaniotis V, Goutakoli P, Liapakis G, Dermitzaki E, Tzardi M, Venihaki M.   +8 more
europepmc   +1 more source

Impact of Fire and Heat Stress on Soil Microorganisms: A Review of Community Changes, Molecular Responses and Plant‐Beneficial Roles

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
This work reviewed the direct and indirect effects of fires on microbial communities and the resilience strategies microbes use to withstand high temperatures . ABSTRACT Fire, whether occurring on the surface or underground, significantly influences soil microbial dynamics by reshaping community composition, functional diversity and overall soil and ...
Ma. del Carmen Orozco‐Mosqueda, Aurora Flores‐Piña, Ajay Kumar, Fannie I. Parra‐Cota, Sergio de los Santos‐Villalobos, Debasis Mitra, Olubukola Oluranti Babalola, Gustavo Santoyo   +7 more
wiley   +1 more source

Involvement of L polymerase and heat shock proteins in the biogenesis of viral circular RNAs derived from respiratory syncytial virus. [PDF]

mBio
Lin M, Miao S, Yang X, Qiu Y, Mai Z, Xiao Y, Xie M, Luo Y, Ma C, Liu J, Liu Z, Yao W.   +11 more
europepmc   +1 more source

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Development of a chaperone-mediated protein degrader targeting ERK5 that efficaciously reduces tumor growth. [PDF]

Cell Commun Signal
Yang X, Yin W, Xu M, Tusa I, Menconi A, Dai Y, Ding Q, Wang G, Foley KP, Rovida E, Ying W.   +10 more
europepmc   +1 more source