Integrative Zoology, EarlyView.Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong +7 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu +8 more
wiley +1 more source
Supplementary Figure 1 from A Purine Scaffold HSP90 Inhibitor BIIB021 Has Selective Activity against KSHV-Associated Primary Effusion Lymphoma and Blocks vFLIP K13-Induced NF-κB [PDF]
, 2023 Gopalakrishnan Ramakrishnan +2 more
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Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Μελέτη της πρωτεΐνης heat shock protein 90 (HSP90) σε καρκινικά φαινόμενα [PDF]
, 2009 Dimitris Stellas
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Supplementary Data from A Novel HSP90 Inhibitor Delays Castrate-Resistant Prostate Cancer without Altering Serum PSA Levels and Inhibits Osteoclastogenesis [PDF]
, 2023 François Lamoureux +6 more
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Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer
Cancer Science, EarlyView.YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh +6 more
wiley +1 more source
Morphology and DNA sequence data reveal the presence of Globodera ellingtonae in the Andean region [PDF]
, 2014 Potato cyst nematodes, G. rostochiensis and G. pallida, are the most economically important nematode pests of potatoes worldwide and are subject to strict quarantine regulations in many countries. Globodera ellingtonae was recently described from Oregon (
Doucet, Marcelo Edmundo +4 more
core
Structure of the RPAP3:TRBP interaction reveals an involvement of the HSP90/R2TP chaperone complex in dsRNA pathways [PDF]
, 2020 Yoann Abel +10 more
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