Results 31 to 40 of about 132,845 (313)

Heat shock protein 90 in neurodegenerative diseases

Molecular Neurodegeneration, 2010
Hsp90 is a molecular chaperone with important roles in regulating pathogenic transformation. In addition to its well-characterized functions in malignancy, recent evidence from several laboratories suggests a role for Hsp90 in maintaining the functional ...
Rodina Anna, Taldone Tony, Sun Weilin, Luo Wenjie, Chiosis Gabriela   +4 more
doaj   +1 more source

Inhibition of Heat Shock proteins HSP90 and HSP70 induce oxidative stress, suppressing cotton fiber development

Scientific Reports, 2018
Cotton fiber is a specialized unicellular structure useful for the study of cellular differentiation and development. Heat shock proteins (HSPs) have been shown to be involved in various developmental processes. Microarray data analysis of five Gossypium
Anshulika Sable, K. M. Rai, A. Choudhary, V. K. Yadav, S. K. Agarwal, S. Sawant   +5 more
semanticscholar   +1 more source

Mechanisms of Hsp90 regulation [PDF]

, 2016
Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of disparate client proteins. This implicates Hsp90 in diverse biological processes that require a variety of co-ordinated regulatory mechanisms to control its ...
Ahn, Akira, Ali, Ali, Amin, Ammirante, Anckar, Anckar, Azevedo, Bali, Bandhakavi, Bansal, Bansal, Bansal, Barlev, Bharadwaj, Blank, Boellmann, Bonizzi, Bonner, Broemer, Brown, Bruce, Budzynski, Bulman, Catlett, Chen, Chen, Chen, Chen, Cho, Chrisostomos Prodromou, Combates, Cotto, Csermely, Cunningham, da Silva Correia, Deb, Dunn, Echeverria, Ehret, Espinosa, Farkas, Field, Finka, Frey, Geiss-Friedlander, Gerondakis, Ghosh, Gomez, Grad, Graf, Gugasyan, Gupta, Hashikawa, Hashikawa, Heimberger, Hensold, Hessling, Hickey, Hietakangas, Holmberg, Holmberg, Holt, Horejsi, Hubert, Ito, Jakob, Johnson, Jurivich, Kadota, Kekatpure, Kettenbach, Kitagawa, Kline, Knauf, Kobayashi, Kugel, Legagneux, Lei, Leskovar, Li, Li, Lindquist, Lingelbach, Liu, Liu, Longshaw, Lu, Makhnevych, Martinez-Ruiz, Mayor, McConnell, McLaughlin, Meyer, Meyer, Meyer, Mitsiades, Miyata, Miyata, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Morimoto, Muller, Murphy, Murtagh, Napetschnig, Neef, Newton, Nieto-Sotelo, Oeckinghaus, Ogiso, Onuoha, Panaretou, Park, Pattaramanon, Pearl, Pearl, Pelham, Peteranderl, Picard, Pirkkala, Pittet, Pratt, Pratt, Prodromou, Prodromou, Prodromou, Prodromou, Prodromou, Qing, Quanz, Rabindran, Rebbe, Retzlaff, Retzlaff, Richter, Roe, Rutherford, Sakurai, Sbroggio, Scheufler, Schuler, Scroggins, Shamovsky, Shao, Shen, Shi, Shiau, Shirasu, Siligardi, Siligardi, Smale, Smith, Solier, Sorger, Sorger, Sorger, Southworth, Steensgaard, Stephanou, Stephanou, Taipale, Takahashi, Takai, Vaughan, Vaughan, Verghese, Voellmy, Voss, Vujanac, Wandinger, Wang, Weikl, Westerheide, Whitesell, Wiederrecht, Williams, Xiao, Xu, Xu, Yahara, Yamamoto, Yang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhong, Zhou, Zou, Zuehlke, Zuo, Zuo   +199 more
core   +1 more source

Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo

Journal of Biological Chemistry, 2010
Several Hsp90 (heat shock protein 90) inhibitors are currently under clinical evaluation as anticancer agents. However, the correlation between the duration and magnitude of Hsp90 inhibition and the downstream effects on client protein degradation and ...
Bonnie P. Tillotson, K. Slocum, J. Coco, Nigel Whitebread, Brian Thomas, K. West, J. Macdougall, J. Ge, J. Ali, V. Palombella, E. Normant, J. Adams, C. Fritz   +12 more
semanticscholar   +1 more source

Heat shock proteins as biomarkers of lung cancer

Cancer Biology & Therapy, 2020
Heat shock proteins are known to be associated with a wide variety of human cancers including lung cancer. Overexpression of these molecular chaperones is linked with tumor survival, metastasis and anticancer drug resistance.
Sonam Mittal, M. S. Rajala
semanticscholar   +1 more source

Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N‐terminal Inhibitors Without Induction of Heat Shock Response

ChemistryOpen, 2019
Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency.
Dr. Peng Liu, Dr. Xiangling Chen, Dr. Jianming Zhu, Dr. Bo Li, Dr. Zhaoqiang Chen, Dr. Guimin Wang, Dr. Haiguo Sun, Dr. Zhijian Xu, Dr. Zhixin Zhao, Dr. Chen Zhou, Dr. Chengying Xie, Prof. Liguang Lou, Prof. Weiliang Zhu   +12 more
doaj   +1 more source

A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]

, 2011
Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta, Altieri, Amal Shervington, Bagatell, Basso, Bisht, Boado, Brader, Braga-Basaria, Burger, Chang, Chatterjee, Chinmay Munje, Chiosis, Clarke, Cohen-Saidon, Cruickshanks, Duerfeldt, Elbashir, Eustace, Gaspar, Gazitt, Goetz, Graner, Han, Isaacs, Jane, Kamal, Kamal, Karkoulis, Koren, Kumar, Lang, Lanneau, Leroy Shervington, Li, Luo, McAnuff, McCollum, Padmini, Porter, Pu, Pu, Sauvageot, Schiffelers, Shervington, Shim, Siegelin, Solit, Sreedhar, Stommel, Walsh, Whitesell, Yang, Yen, Yu   +55 more
core   +2 more sources

Surviving the heat of the moment : a fungal pathogens perspective [PDF]

, 2013
Peer reviewedPublisher ...
Cowen, Leah E, Leach, Michelle D
core   +2 more sources

Heterocyclic Compounds as Hsp90 Inhibitors: A Perspective on Anticancer Applications

Pharmaceutics, 2022
Heat shock proteins (Hsps) have garnered special attention in cancer therapy as molecular chaperones with regulatory/mediatory effects on folding, maintenance/stability, maturation, and conformation of proteins as well as their effects on prevention of ...
Mina Ardestani, Zahra Khorsandi, Fariba Keshavarzipour, Siavash Iravani, Hojjat Sadeghi-Aliabadi, Rajender S. Varma   +5 more
doaj   +1 more source

Heat stress induces expression of HSP genes in genetically divergent chickens. [PDF]

PLoS ONE, 2017
BACKGROUND:Chickens are animals that are sensitive to thermal stress, which may decrease their production level in terms that it affects feed intake and thus, decreasing body weight gain.
Haniel Cedraz, Juliana Gracielle Gonzaga Gromboni, Antonio Amandio Pinto Garcia, Ronaldo Vasconcelos Farias Filho, Teillor Machado Souza, Eduardo Ribeiro de Oliveira, Elizangela Bonfim de Oliveira, Carlos Souza do Nascimento, Camila Meneghetti, Amauri Arias Wenceslau   +9 more
doaj   +1 more source