Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance
Cells, 2022 Heat shock protein (HSP90), a highly conserved molecular chaperon, is indispensable for the maturation of newly synthesized poly-peptides and provides a shelter for the turnover of misfolded or denatured proteins. In cancers, the client proteins of HSP90
Jian Zhang +7 more
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Опухоли головы и шеи, 2017 Objective: in paper direct results of investigation the products of tumor makers – CEA (carcino-embryonic antigen), CYFRA 21-1 and SCC and heat shock proteins hsp27, hsp70, hsp90.
I. I. Nazmudinov, M. Z. Saidov
doaj +1 more source
Nuclear HSP90 and HSP70 in COPD patients treated with formoterol or formoterol and corticosteroids
European Journal of Medical Research, 2009 Objective Heat shock proteins assist cellular protein folding and are required for the normal activity of steroid receptors. In this study we assessed nuclear HSP90 and HSP70 proteins and mRNA levels in cells isolated from induced sputum of chronic ...
Holownia A +4 more
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Heat Shock Proteins: Agents of Cancer Development and Therapeutic Targets in Anti-Cancer Therapy
Cells, 2019 Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90.
C. Yun +3 more
semanticscholar +1 more source
Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals [PDF]
, 2009 Peer reviewedPublisher ...
Brown, Alistair J. P. +3 more
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Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach
International Journal of Molecular Sciences, 2017 Heat shock proteins (HSPs) are a large family of chaperones that are involved in protein folding and maturation of a variety of “client” proteins protecting them from degradation, oxidative stress, hypoxia, and thermal stress. Hence, they are significant
S. Chatterjee, T. Burns
semanticscholar +1 more source
Redox Biology, 2019 Aging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of ...
José Pedro Castro +5 more
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The Onset of Molecule‐Spanning Dynamics in Heat Shock Protein Hsp90
Advanced Science, 2023 AbstractProtein dynamics have been investigated on a wide range of time scales. Nano‐ and picosecond dynamics have been assigned to local fluctuations, while slower dynamics have been attributed to larger conformational changes. However, it is largely unknown how fast (local) fluctuations can lead to slow global (allosteric) changes.
Sohmen, Benedikt +11 more
openaire +6 more sources
Membrane fluidity and temperature sensing are coupled via circuitry comprised of Ole1, Rsp5, and Hsf1 in Candida albicans [PDF]
, 2014 Peer reviewedPublisher ...
Cowen, Leah E., Leach, Michelle D.
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Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 [PDF]
, 2017 We thank Zhen-Yuan Lin for help in the preparation of the AP-MS samples, and Cathy Collins for technical assistance. MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), LEC is supported by a Canada Research Chair in ...
Bohovych, Iryna +7 more
core +4 more sources