Results 41 to 50 of about 59,353 (250)

In silico genomic and proteomic analyses of three heat shock proteins (HSP70, HSP90-α, and HSP90-β) in even-toed ungulates

Electronic Journal of Biotechnology, 2021
Background: Heat shock proteins (HSPs) play important roles in the responses to different environmental stresses. In this study, the genomic and proteomic characteristics of three HSPs (HSP70, HSP90-α and HSP90-β) in five even-toed ungulates (sheep ...
Sayed Haidar Abbas Raza, Abdallah A. Hassanin, Aya I.M. Dhshan, Sameh A. Abdelnour, Rajwali Khan, Chugang Mei, Linsen Zan   +6 more
doaj   +1 more source

Heat Shock Protein 90 (HSP90) and Immune Regulation

Journal of Bacteriology and Virology, 2015
Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating humoral and cellular immune responses.
Bo-Kyung Kim, So-Youn Woo
openaire   +1 more source

The 90-kDa Heat Shock Protein Hsp90 Protects Tubulin against Thermal Denaturation [PDF]

Journal of Biological Chemistry, 2010
Hsp90 and tubulin are among the most abundant proteins in the cytosol of eukaryotic cells. Although Hsp90 plays key roles in maintaining its client proteins in their active state, tubulin is essential for fundamental processes such as cell morphogenesis and division. Several studies have suggested a possible connection between Hsp90 and the microtubule
Weis, Felix, Moullintraffort, Laura, Heichette, Claire, Chrétien, Denis, Garnier, Cyrille   +4 more
openaire   +2 more sources

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. [PDF]

, 2019
Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress.
Chen, Xuemei, Dai, Xiaoxia, Li, Lin, Miao, Weili, Wang, Yinsheng, Zhao, Yonghui   +5 more
core   +1 more source

A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity. [PDF]

, 2014
Hsp90 is a conserved chaperone that facilitates protein homeostasis. Our crystal structure of the mitochondrial Hsp90, TRAP1, revealed an extension of the N-terminal β-strand previously shown to cross between protomers in the closed state. In this study,
Agard, David A, Cooke, Roger, Elnatan, Daniel, Lavery, Laura A, Naber, Nariman, Partridge, James R   +5 more
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Heat shock protein 90: biological functions, diseases, and therapeutic targets

MedComm
Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in the folding, stabilization, and modification of diverse protein substrates. It collaborates
Huiyun Wei, Yingying Zhang, Yilin Jia, Xunan Chen, Tengda Niu, Aniruddha Chatterjee, Pengxing He, Guiqin Hou   +7 more
doaj   +1 more source

The heat shock protein 90 of Toxoplasma gondii is essential for invasion of host cells and tachyzoite growth

Parasite, 2017
Toxoplasma gondii is an obligate intracellular apicomplexan parasite that infects almost all warm-blooded vertebrates. Heat shock proteins (HSP) regulate key signal transduction events in many organisms, and heat shock protein 90 (Hsp90) plays an ...
Sun Hongchao, Zhuo Xunhui, Zhao Xianfeng, Yang Yi, Chen Xueqiu, Yao Chaoqun, Du Aifang   +6 more
doaj   +1 more source

Heat shock protein and heat shock factor 1 expression and localization in vaccinia virus infected human monocyte derived macrophages

Journal of Inflammation, 2005
Background Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (MDMs) as blood cells usually ...
Dziedzic Jakub, Slezak Kinga, Guzik Krzysztof, Kowalczyk Aleksandra, Rokita Hanna   +4 more
doaj   +1 more source

Geldanamycin and its derivatives as Hsp90 inhibitors [PDF]

, 2012
The Hsp90 molecule, one of the most abundant heat shock proteins in mammalian cells, maintains homeostasis and prevents stress-induced cellular damage.
BUCCHIERI, Fabio, CICERO, Giuseppe, Gorska, M., Knap, N., Kuban Jankowska, A., Popowska, U., Sawczuk, W., Sielicka Dudzin, A., Wozniak, F.   +8 more
core   +1 more source