Genital HSV-1 infections [PDF]
Sexually Transmitted Infections, 2006 Importantly, individuals with genital HSV-1 are still at risk of HSV-2 acquisition In the past decade, investigations have amply documented the increase in the frequency of genital herpes simplex virus type 1 (HSV-1) compared with genital HSV-2 infection.
openaire +2 more sources
The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice is a Major Cause of CNS Pathology Resulting in Fatal Encephalitis [PDF]
, 2008 This study was undertaken to investigate possible immune mechanisms in fatal HSV-1 encephalitis (HSE) after HSV-1 corneal inoculation. Susceptible 129S6 (129) but not resistant C57BL/6 (B6) mice developed intense focal inflammatory brainstem lesions of ...
Brown, Jeffrey +10 more
core +2 more sources
Seroprevalence of herpes simplex virus type 1 and type 2 among the migrant workers in Qatar
Virology Journal, 2023 Background Limited data exists on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections in migrant populations. This study investigated HSV-1 and HSV-2 seroprevalences and associations among craft and manual workers (CMWs) in Qatar who ...
Gheyath K. Nasrallah +47 more
doaj +1 more source
Intervirology, 1993 Neuroinvasiveness, the capacity of virus to enter and progress through the nervous system, may be accomplished by hematogenous or neural routes. We have been interested in defining HSV-1 genes specifically concerned with the neural pathway. In one system (involving HSV strain Ang), we have found that a single amino acid change in glycoprotein D, a ...
openaire +3 more sources
Characterization of the Interaction between the Herpes Simplex Virus Type I Fc Receptor and Immunoglobulin G [PDF]
, 1999 Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding.
Bjorkman, Pamela J. +5 more
core +1 more source
LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. [PDF]
PLoS ONE, 2012 After HSV infection, some trigeminal ganglion neurons support productive cycle gene expression, while in other neurons the virus establishes a latent infection.
Andrea S Bertke +8 more
doaj +1 more source
Herpes Simplex Virus 1 and 2 Infections during Differentiation of Human Cortical Neurons
Viruses, 2021 Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) can infect the central nervous system (CNS) with dire consequences; in children and adults, HSV-1 may cause focal encephalitis, while HSV-2 causes meningitis.
Petra Bergström +13 more
doaj +1 more source
Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]
, 2013 Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
core +1 more source
Viruses, 2023 The thymidine kinase (TK) and DNA polymerase (pol) genes of the herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) are two important genes involved in antiviral resistance.
Jungwon Hyun +7 more
doaj +1 more source
Upstream-binding factor is sequestered into herpes simplex virus type 1 replication compartments [PDF]
, 2009 Previous reports have shown that adenovirus recruits nucleolar protein upstream-binding factor (UBF) into adenovirus DNA replication centres. Here, we report that despite having a different mode of viral DNA replication, herpes simplex virus type 1 (HSV ...
Ahmed +25 more
core +2 more sources