Results 111 to 120 of about 63,605 (287)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Mycotoxins at the Start of the Food Chain in Costa Rica: Analysis of Six Fusarium Toxins and Ochratoxin A between 2013 and 2017 in Animal Feed and Aflatoxin M₁ in Dairy Products

Toxins, 2019
Mycotoxins are secondary metabolites, produced by fungi of genera Aspergillus, Penicillium and Fusarium (among others), which produce adverse health effects on humans and animals (carcinogenic, teratogenic and immunosuppressive).
Andrea Molina, Guadalupe Chavarría, Margarita Alfaro-Cascante, Astrid Leiva, Fabio Granados-Chinchilla   +4 more
doaj   +1 more source

Phase transition in a spatial Lotka-Volterra model

, 2000
Spatial evolution is investigated in a simulated system of nine competing and mutating bacterium strains, which mimics the biochemical war among bacteria capable of producing two different bacteriocins (toxins) at most.
A.J. Lotka, B. Sinervo, F.Y. Wu, G. Grinstein, G. Szabó, György Szabó, J. Hofbauer, J. Maynard Smith, K. Binder, K. Binder, K. Tainaka, L. Frachebourg, L. Frachebourg, M. Bramson, P. Reeves, R.B. Potts, Tamás Czárán, V. Volterra   +17 more
core   +1 more source

Validated UPLC-MS/MS methods to quantitate free and conjugated Alternaria toxins in commercially available tomato products and fruit and vegetable juices in Belgium [PDF]

, 2016
Ultraperformance liquid chromatography tandem mass spectrometry and Quick, Easy, Cheap, Effective, Rugged, and Safe based analytical methodologies to quantitate both free (alternariol (1), alternariol monomethyl ether (2), tenuazonic acid (3), tentoxin ...
Asam, Stefan, De Saeger, Sarah, Devos, Tom, Diana Di Mavungu, José, Jacxsens, Liesbeth, Mikula, Hannes, Njumbe Ediage, Emmanuel, Rychlik, Michael, Van Landschoot, Anita, Vanhaecke, Lynn, Walravens, Jeroen   +10 more
core   +3 more sources

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Characterization of the Adherence of Clostridium difficile Spores: The Integrity of the Outermost Layer Affects Adherence Properties of Spores of the Epidemic Strain R20291 to Components of the Intestinal Mucosa [PDF]

, 2016
Indexación: Web of Science.Clostridium difficile is the causative agent of the most frequently reported nosocomial diarrhea worldwide. The high incidence of recurrent infection is the main clinical challenge of C. difficile infections (CBI). Formation of
Banawas, Saeed, Calderón, Iván, Castro-Córdova, Pablo, Fuentes, Juan A., Gil, Fernando, Miranda-Cárdenas, Camila, Mora-Uribe, Paola, Paredes-Sabja, Daniel, Rodas, Paula I., Sarker, Mahfuzur R.   +9 more
core   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Seeds of Doubt: North American farmers' experiences of GM crops [PDF]

, 2002
The picture the biotechnology industry has painted of GM crops in North America is one of unqualified success, after six years of commercial growing. The objective of this report was to assess whether this image is accurate and if not what problems have ...
Meziani, Gundula, Warwick, Hugh
core  

Development of a multiplex flow cytometric microsphere immunoassay for mycotoxins and evaluation of its application in feed [PDF]

A multi-mycotoxin immunoassay—using the MultiAnalyte Profiling (xMAP) technology—is developed and evaluated. This technology combines a unique color-coded microsphere suspension array, with a dedicated flow cytometer.
Haasnoot, W., Peters, J., Ploum, M.E., Rijk, T.C., de   +3 more
core   +2 more sources