Results 101 to 110 of about 10,923,960 (347)

Identifying the hub gene in gastric cancer by bioinformatics analysis and in vitro experiments

Cell Cycle, 2020
Gastric cancer (GC) is one of the main causes of the high death rate in the world. But the molecular mechanisms of GC carcinogenesis remain little known.
Fei-Ran Wang, Q. Xue, Dong Xu, Yasu Jiang, Chong Tang, Xian-Cheng Liu   +5 more
semanticscholar   +1 more source

Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 Infection

Journal of Clinical Medicine, 2021
The coronavirus disease-2019 (COVID-19) pandemic has caused an enormous loss of lives. Various clinical trials of vaccines and drugs are being conducted worldwide; nevertheless, as of today, no effective drug exists for COVID-19.
H. Karami, Afshin Derakhshani, Mohammad Ghasemigol, M. Fereidouni, E. Miri-Moghaddam, B. Baradaran, Neda Jalili Tabrizi, S. Najafi, A. Solimando, L. Marsh, N. Silvestris, S. De Summa, A. Paradiso, V. Racanelli, H. Safarpour   +14 more
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Gene co-expression network analysis reveals key pathways and hub genes in Chinese cabbage (Brassica rapa L.) during vernalization

BMC Genomics, 2021
Vernalization is a type of low temperature stress used to promote rapid bolting and flowering in plants. Although rapid bolting and flowering promote the reproduction of Chinese cabbages (Brassica rapa L. ssp.
Yun Dai, Xiao Sun, Cheng-Gang Wang, Fei Li, Shi-fan Zhang, Hui Zhang, Guoliang Li, Ling-Yun Yuan, Guo-Hu Chen, R. Sun, Shujiang Zhang   +10 more
semanticscholar   +1 more source

Identification of the hub genes RUNX2 and FN1 in gastric cancer [PDF]

Open Medicine, 2020
Abstract Background This study identified key genes in gastric cancer (GC) based on the mRNA microarray GSE19826 from the Gene Expression Omnibus (GEO) database and preliminarily explored the relationships among the key genes. Methods
Han Chao, Jin Lei, Ma Xuemei, Hao Qin, Lin Huajun, Zhang Zhongtao   +5 more
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Mechanisms of cellular senescence combined with molecular docking strategies: A biomarker study of potential therapeutic targets for allergic rhinitis.

PLoS ONE
ObjectiveBioinformatics and molecular docking methods were used to screen potential biomarkers of cellular senescence in allergic rhinitis (Allergic rhinitis AR), which provided a theoretical basis for revealing the mechanism of AR and exploring new ...
Qingyong Chen, Han Zhang, Yue Wu, Jixin Liu, Dongqing Wang, Dezhong Sun, Zhipeng Chen, Liqiang Lin, Huaiqing Lv, Qiang Shao   +9 more
doaj   +1 more source

The Identification and Validation of Hub Genes Associated with Acute Myocardial Infarction Using Weighted Gene Co-Expression Network Analysis

Journal of Cardiovascular Development and Disease, 2022
Acute myocardial infarction (AMI), one of the most severe and fatal cardiovascular diseases, remains the main cause of mortality and morbidity worldwide.
Junqiang Xue, Lu Chen, Hao Cheng, Xiao-Yue Song, Yuekai Shi, Lin-Nan Li, Ren-De Xu, Q. Qin, Jianying Ma, Jun-Bo Ge   +9 more
semanticscholar   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

NUMERICAL ANALYSIS OF HUB AND FUSELAGE INTERFERENCE TO REDUCE HELICOPTER DRAG [PDF]

, 2012
A numerical investigation was carried out to predict the mutual interference between helicopter components. The investigation was based on the solution of RANS equations in three dimensions using unstructured grids.
Khier, Walid
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