Results 91 to 100 of about 10,923,960 (347)

Identification of Hub Biomarkers and Immune-Related Pathways Participating in the Progression of Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis

Frontiers in Immunology, 2022
BackgroundAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease that generally induces the progression of rapidly progressive glomerulonephritis (GN).
Meng-Di Xia, Meng-Di Xia, Rui-Ran Yu, Dong-Ming Chen, Dong-Ming Chen   +4 more
doaj   +1 more source

Identification of Hub Genes Associated with Breast Cancer Using Integrated Gene Expression Data with Protein-Protein Interaction Network

Applied Sciences, 2023
Breast cancer (BC) is the most incident cancer type among women. BC is also ranked as the second leading cause of death among all cancer types. Therefore, early detection and prediction of BC are significant for prognosis and in determining the suitable ...
M. Elbashir, Mohanad Mohammed, H. Mwambi, B. Omolo   +3 more
semanticscholar   +1 more source

Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers

Scientific Reports, 2023
AbstractOsteoarthritis (OA) is a progressive cartilage degradation disease, concomitant with synovitis, osteophyte formation, and subchondral bone sclerosis. Over 37% of the elderly population is affected by OA, and the number of cases is increasing as the global population ages.
Junfeng Zeng, Xinhao Jiang, Mo Jiang, Yuexia Cao, Yi Jiang   +4 more
openaire   +3 more sources

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

LUM is the hub gene of advanced fibrosis in nonalcoholic fatty liver disease patients.

Clinics And Research in Hepatology and Gastroenterology, 2020
INTRODUCTION Advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is associated with a poor prognosis. The genetic factors contributing to fibrosis in NAFLD have been described.
Yue Chang, Jiange He, Xiao-Hui Xiang, Hai Li   +3 more
semanticscholar   +1 more source

Mutant NPM1 hijacks transcriptional hub to maintain pathogenic gene programs in acute myeloid leukemia

Cancer Discovery, 2022
Nucleophosmin (NPM1) is a ubiquitously expressed nucleolar protein with a wide range of biological functions. In 30% of acute myeloid leukemia (AML), the terminal exon of NPM1 is often found mutated, resulting in the addition of a nuclear export signal ...
X. Q. Wang, D. Fan, Qin-Yu Han, Yiman Liu, H. Miao, Xin-Yu Wang, Qinglan Li, Dong Chen, Haley Gore, Pamela Himadewi, G. Pfeifer, T. Cierpicki, J. Grembecka, Jianzhong Su, Shasha Chong, L. Wan, Xiaotian Zhang   +16 more
semanticscholar   +1 more source

Identification and Validation of Hub Genes in Acute Pancreatitis and Hypertriglyceridemia

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2022
The pathogenesis of acute pancreatitis (AP) and the relationship between acute pancreatitis and hypertriglyceridemia are complex and not fully understood. The purpose of this study was to identify the hub genes along with common differentially expressed genes (DEGs) between acute pancreatitis and hypertriglyceridemia.We downloaded three gene expression
Shiyu Zhang, Zhihai Liang, Xuelian Xiang, Li Liu, Huiying Yang, Guodu Tang   +5 more
openaire   +5 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Adrenocortical carcinoma survival gene HMMR was identified as being targeted by fluorouracil and epirubicin using a gene coexpression network-based drug repositioning strategy

Scientific Reports
Adrenocortical carcinoma (ACC), with poor prognosis, is one of the most aggressive endocrine cancers. Surgery is the mainstay of treatment; nevertheless, chemotherapy is usually needed.
Zahra Jafari, Seyed-Morteza Javadirad, Seyede Elmira Yazdi Rouholamini   +2 more
doaj   +1 more source

Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes: a bioinformatics analysis [PDF]

International Journal of Ophthalmology
AIM: To prevent neovascularization in diabetic retinopathy (DR) patients and partially control disease progression. METHODS: Hypoxia-related differentially expressed genes (DEGs) were identified from the GSE60436 and GSE102485 datasets, followed by gene ...
Cai-Han Yu, Cai-Xia Wu, Dai Li, Lan-Lan Gong, Xu-Dong Lyu, Jie Yang   +5 more
doaj   +1 more source