Results 91 to 100 of about 245,963 (292)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology [PDF]
, 2015 We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene).
Ali, SS +17 more
core
Master Regulators, Regulatory Networks, and Pathways of Glioblastoma Subtypes [PDF]
, 2014 Glioblastoma multiforme (GBM) is the most common malignant brain tumor. GBM samples are classified into subtypes based on their transcriptomic and epigenetic profiles.
+4 more
core +3 more sources
Gene's hubs in retinal diseases: A retinal disease network [PDF]
Heliyon, 2018 Retinal diseases associated with the dysfunction or death of photoreceptors are a major cause of blindness around the world, improvements in genetics tools, like next generation sequencing (NGS) allows the discovery of genes and genetic changes that lead to many of those retinal diseases.
J.M. Lázaro-Guevara +7 more
openaire +3 more sources
Comprehensive Analysis of Hub Genes In Prostate Cancer [PDF]
, 2021 Abstract Abstract：The present study aims to explore the involvement of hub genes in prostate cancer (PCa). Three series were used in this study: GSE46602, GSE5377, and GSE8511 from GPL570 platform in the Gene Expression Omnibus and the other resources from The Cancer Genome Atlas and UCSC Xena. A total of 47 differentially expressed genes (DEGs)
Zhi Yang, JUN MI
openaire +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Journal of Integrative NeuroscienceBackground: Alzheimer’s disease (AD) is a condition that affects the nervous system and that requires considerably more in-depth study. Abnormal Nicotinamide Adenine Dinucleotide (NAD+) metabolism and disulfide levels have been demonstrated in AD.
Yanbing Wang +3 more
doaj +1 more source
The architecture of the protein domain universe [PDF]
, 2004 Understanding the design of the universe of protein structures may provide insights into protein evolution. We study the architecture of the protein domain universe, which has been found to poses peculiar scale-free properties (Dokholyan et al., Proc ...
Dokholyan, Nikolay V.
core +4 more sources
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Large-scale inference and graph theoretical analysis of gene-regulatory networks in B. stubtilis
, 2006 We present the methods and results of a two-stage modeling process that generates candidate gene-regulatory networks of the bacterium B. subtilis from experimentally obtained, yet mathematically underdetermined microchip array data.
Albert +42 more
core +1 more source