Results 1 to 10 of about 194,990 (329)
The Nuclear Lamina as a Gene-silencing Hub [PDF]
Current Issues in Molecular Biology, 2012 There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Yuri Y. Shevelyov
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Identification of the Hub Genes in Alzheimer’s Disease [PDF]
Computational and Mathematical Methods in Medicine, 2021 Purpose. Alzheimer’s disease (AD) is considered to be the most common neurodegenerative disease and also one of the major fatal diseases affecting the elderly, thus bringing a huge burden to society. Therefore, identifying AD-related hub genes is extremely important for developing novel strategies against AD. Materials and Methods.
Huiwen Gui +4 more
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Nuclear speckles: dynamic hubs of gene expression regulation [PDF]
The FEBS Journal, 2021 Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity.
İbrahim Avşar Ilık, Tuğçe Aktaş
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Identification of hub genes for glaucoma: a study based on bioinformatics analysis and experimental verification [PDF]
International Journal of Ophthalmology, 2023 AIM: To explore hub genes for glaucoma based on bioinformatics analysis and an experimental model verification. METHODS: In the Gene Expression Omnibus (GEO) database, the GSE25812 and GSE26299 datasets were selected to analyze differentially expressed ...
Rui-Ling Xie, Hai-Yan Nie, Yu-Xin Xu
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Frontiers in Immunology, 2022 PurposeTo identify biomarkers associated with CD8+ T cells in coronary artery disease (CAD) and initially explore their potential role in the tumor immune microenvironment.Materials and MethodsCAD-related datasets GSE12288, GSE34198, and GSE66360, were ...
Shijian Zhao +4 more
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Frontiers in Pharmacology, 2022 Objectives: Lung cancer is one of the most common cancers worldwide and it is the leading cause of cancer-related mortality. Despite the treatment of patients with non-small cell lung carcinoma (NSCLC) have improved, the molecular mechanisms of NSCLC are
Xie Mengyan +7 more
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Frontiers in Genetics, 2021 Tumor recurrence is one of the most important risk factors that can negatively affect the survival rate of colorectal cancer (CRC) patients. However, the key regulators dictating this process and their exact mechanisms are understudied.
Shengwei Liu +4 more
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PLoS ONE, 2021 IntroductionThe heterogeneity-specific nature of the available colorectal cancer (CRC) biomarkers is significantly contributing to the cancer-associated high mortality rate worldwide.
Yasir Hameed +3 more
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Clinical Values of the Identified Hub Genes in Systemic Lupus Erythematosus
Frontiers in Immunology, 2022 ObjectiveThis study was conducted to identify the biomarkers and mechanisms associated with systemic lupus erythematosus(SLE) at a transcriptome level.MethodsMicroarray datasets were downloaded, and differentially expressed genes (DEGs) were identified ...
Lu Xiao, Feng Zhan, Shudian Lin
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Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation [PDF]
PeerJ, 2022 Background The mechanism of immunoglobulin A nephropathy (IgAN) is still unknown. A bioinformatics analysis is a powerful method to identify the biomarkers and possible therapeutic targets of a certain disease from related datasets.
Wu Jianping +5 more
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