Results 21 to 30 of about 194,990 (329)

Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNγ Regulation [PDF]

, 2015
peer-reviewedData Availability: The raw sequencing reads (FASTQ files) and sequence read counts mapped to UCSC hg19 for each of the 74 transcriptomes sequenced in this study have been deposited at Gene Expression Omnibus (GEO) accession GSE69549.This ...
Castro, Patricia Dominguez, Coleman, Ciara, Cormican, Paul, Mahmud, Nasir, McManus, Ross, Molloy, Ben, Quinn, Emma M, Trimble, Valerie   +7 more
core   +8 more sources

Identification of Hub Genes in Tuberculosis via Bioinformatics Analysis [PDF]

Computational and Mathematical Methods in Medicine, 2021
Background. Tuberculosis (TB) is a serious chronic bacterial infection caused by Mycobacterium tuberculosis (MTB). It is one of the deadliest diseases in the world and a heavy burden for people all over the world. However, the hub genes involved in the host response remain largely unclear. Methods.
Tiancheng Zhang, Guihua Rao, Xiwen Gao
openaire   +2 more sources

Identification of Ten Core Hub Genes as Potential Biomarkers and Treatment Target for Hepatoblastoma

Frontiers in Oncology, 2021
BackgroundThis study aimed to systematically investigate gene signatures for hepatoblastoma (HB) and identify potential biomarkers for its diagnosis and treatment.Materials and MethodsGSE131329 and GSE81928 were obtained from the Gene Expression Omnibus (
Rui Sun, Rui Sun, Simin Li, Ke Zhao, Mei Diao, Long Li   +5 more
doaj   +1 more source

Text Mining and Hub Gene Network Analysis of Endometriosis [PDF]

BioMed Research International, 2021
This study is aimed at systematically characterizing the endometriosis‐associated genes based on text mining and at annotating the functions, pathways, and networks of endometriosis‐associated hub genes. We extracted endometriosis‐associated abstracts published between 1970 and 2020 from the PubMed database.
Yinuo Wang, Songbiao Zhu, Chengcheng Liu, Haiteng Deng, Zhenyu Zhang   +4 more
openaire   +2 more sources

Seven key hub genes identified by gene co-expression network in cutaneous squamous cell carcinoma

BMC Cancer, 2021
Background Cutaneous squamous cell carcinoma (cSCC) often follows actinic keratosis (AK) and is the second most common skin cancer worldwide. To reduce metastasis risk, it is important to diagnose and treat cSCC early.
Huizhen Chen, Jiankang Yang, Wenjuan Wu
doaj   +1 more source

TGF-Beta Induced Key Genes of Osteogenic and Adipogenic Differentiation in Human Mesenchymal Stem Cells and MiRNA–mRNA Regulatory Networks

Frontiers in Genetics, 2021
Background: The clinical efficacy of osteoporosis therapy is unsatisfactory. However, there is currently no gold standard for the treatment of osteoporosis.
Genfa Du, Xinyuan Cheng, Zhen Zhang, Linjing Han, Keliang Wu, Yongjun Li, Xiaosheng Lin   +6 more
doaj   +1 more source

Identification and validation of immune and oxidative stress-related diagnostic markers for diabetic nephropathy by WGCNA and machine learning

Frontiers in Immunology, 2023
BackgroundDiabetic nephropathy (DN) is the primary cause of end-stage renal disease, but existing therapeutics are limited. Therefore, novel molecular pathways that contribute to DN therapy and diagnostics are urgently needed.MethodsBased on the Gene ...
Mingming Xu, Hang Zhou, Ping Hu, Yang Pan, Shangren Wang, Li Liu, Xiaoqiang Liu   +6 more
doaj   +1 more source

Identification of Biomarkers Correlated with the TNM Staging and Overall Survival of Patients with Bladder Cancer

Frontiers in Physiology, 2017
Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li, Sheng Li, Sheng Li, Xiaoping Liu, Tongzu Liu, Xiangyu Meng, Xiaohong Yin, Cheng Fang, Di Huang, Yue Cao, Hong Weng, Xiantao Zeng, Xiantao Zeng, Xinghuan Wang, Xinghuan Wang   +14 more
doaj   +1 more source

Comprehensive analysis and validation of novel immune and vascular remodeling related genes signature associated with drug interactions in pulmonary arterial hypertension

Frontiers in Genetics, 2022
Background: Previous studies revealed that the gene signatures are associated with the modulation and pathogenesis of pulmonary arterial hypertension (PAH).
Jie Wang, Md. Nazim Uddin, Rui Wang, Yue-hong Gong, Yun Wu   +4 more
doaj   +1 more source

SWIM: A computational tool to unveiling crucial nodes in complex biological networks [PDF]

, 2017
SWItchMiner (SWIM) is a wizard-like software implementation of a procedure, previously described, able to extract information contained in complex networks.
Colombo, Teresa, Farina, Lorenzo, Fiscon, Giulia, Gurtner, Aymone, Paci, Paola, Pavesi, Giulio   +5 more
core   +2 more sources