Results 21 to 30 of about 100,698 (279)
Identification of Hub Genes in Tuberculosis via Bioinformatics Analysis [PDF]
Computational and Mathematical Methods in Medicine, 2021 Background. Tuberculosis (TB) is a serious chronic bacterial infection caused by Mycobacterium tuberculosis (MTB). It is one of the deadliest diseases in the world and a heavy burden for people all over the world. However, the hub genes involved in the host response remain largely unclear. Methods.
Tiancheng Zhang, Guihua Rao, Xiwen Gao
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Identification of Ten Core Hub Genes as Potential Biomarkers and Treatment Target for Hepatoblastoma
Frontiers in Oncology, 2021 BackgroundThis study aimed to systematically investigate gene signatures for hepatoblastoma (HB) and identify potential biomarkers for its diagnosis and treatment.Materials and MethodsGSE131329 and GSE81928 were obtained from the Gene Expression Omnibus (
Rui Sun +5 more
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The Nuclear Lamina as a Gene-silencing Hub [PDF]
Current Issues in Molecular Biology, 2012 There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are maintained in a silent state, waiting to be awakened during cell differentiation.
Shevelyov, Yuri Y., Nurminsky, Dmitry I.
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Text Mining and Hub Gene Network Analysis of Endometriosis [PDF]
BioMed Research International, 2021 This study is aimed at systematically characterizing the endometriosis‐associated genes based on text mining and at annotating the functions, pathways, and networks of endometriosis‐associated hub genes. We extracted endometriosis‐associated abstracts published between 1970 and 2020 from the PubMed database.
Yinuo Wang +4 more
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Frontiers in Cellular Neuroscience, 2023 Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs +11 more
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Frontiers in Genetics, 2022 Background: Previous studies revealed that the gene signatures are associated with the modulation and pathogenesis of pulmonary arterial hypertension (PAH).
Jie Wang +4 more
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Frontiers in Immunology, 2023 BackgroundDiabetic nephropathy (DN) is the primary cause of end-stage renal disease, but existing therapeutics are limited. Therefore, novel molecular pathways that contribute to DN therapy and diagnostics are urgently needed.MethodsBased on the Gene ...
Mingming Xu +6 more
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Frontiers in Physiology, 2017 Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li +14 more
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Examination of the relationship between essential genes in PPI network and hub proteins in reverse nearest neighbor topology [PDF]
, 2010 Background In many protein-protein interaction (PPI) networks, densely connected hub proteins are more likely to be essential proteins. This is referred to as the "centrality-lethality rule", which indicates that the topological placement of a protein in
Leong, Hon Wai +4 more
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cis-regulatory circuits regulating NEK6 kinase overexpression in transformed B cells Are super-enhancer independent [PDF]
, 2017 Alterations in distal regulatory elements that control gene expression underlie many diseases, including cancer. Epigenomic analyses of normal and diseased cells have produced correlative predictions for connections between dysregulated enhancers and ...
Huang, Yue +6 more
core +3 more sources