Results 41 to 50 of about 100,698 (279)

Identification of novel potential biomarkers in infantile hemangioma via weighted gene co-expression network analysis

open access: yesBMC Pediatrics, 2022
Background Infantile hemangioma (IH) is the most common benign tumor in children and is characterized by endothelial cells proliferation and angiogenesis. Some hub genes may play a critical role in angiogenesis. This study aimed to identify the hub genes
Bin Xie, Xiongming Zhou, Jiaxuan Qiu
doaj   +1 more source

Identification of the prognostic biomarkers and their correlations with immune infiltration in colorectal cancer through bioinformatics analysis and in vitro experiments

open access: yesHeliyon, 2023
Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading cause of cancer death. The objective was to identify novel hub genes that were helpful for prognosis and targeted therapy in CRC. GSE23878, GSE24514, GSE41657, GSE81582
Min Guo, Xiaxi Li, Jiong Li, Baolong Li
doaj   +1 more source

Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. [PDF]

open access: yes, 2017
Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture.
Ahn, Richard S   +9 more
core   +1 more source

Overexpression of a Prefoldin β subunit gene reduces biomass recalcitrance in the bioenergy crop Populus. [PDF]

open access: yes, 2020
Prefoldin (PFD) is a group II chaperonin that is ubiquitously present in the eukaryotic kingdom. Six subunits (PFD1-6) form a jellyfish-like heterohexameric PFD complex and function in protein folding and cytoskeleton organization.
Barry, Kerrie   +20 more
core   +1 more source

Identification and Validation of Autophagy-Related Genes in Primary Ovarian Insufficiency by Gene Expression Profile and Bioinformatic Analysis

open access: yesAnalytical Cellular Pathology, 2022
Background. To investigate the relationship between primary ovarian insufficiency and autophagy, we detected and got the expression profile of human granulosa cell line SVOG, which was with or without LPS induced. The expression profile was analyzed with
Siji Lv, Jiani Sun, Jing Sun
doaj   +1 more source

Nuclear pore complexes as hubs for gene regulation [PDF]

open access: yesNucleus, 2018
Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
openaire   +2 more sources

Analysis of multiple databases identifies crucial genes correlated with prognosis of hepatocellular carcinoma

open access: yesScientific Reports, 2022
Despite advancements made in the therapeutic strategies on hepatocellular carcinoma (HCC), the survival rate of HCC patient is not satisfactory enough. Therefore, there is an urgent need for the valuable prognostic biomarkers in HCC therapy.
Zhifeng Lin   +5 more
doaj   +1 more source

From access and integration to mining of secure genomic data sets across the grid [PDF]

open access: yes, 2007
The UK Department of Trade and Industry (DTI) funded BRIDGES project (Biomedical Research Informatics Delivered by Grid Enabled Services) has developed a Grid infrastructure to support cardiovascular research.
Sinnott, R.O.
core   +2 more sources

The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma [PDF]

open access: yes, 2020
BACKGROUND: Reference genome and transcriptome assemblies of helminths have reached a level of completion whereby secondary analyses that rely on accurate gene estimation or syntenic relationships can be now conducted with a high level of confidence ...
James, Katherine, Olson, Peter D.
core   +2 more sources

Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis

open access: yesFrontiers in Aging Neuroscience, 2020
Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways.Methods: A co-expression network for an AD gene dataset with 401 ...
Rui-ting Hu   +6 more
doaj   +1 more source

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