Results 41 to 50 of about 107,360 (249)
Key genes and regulatory networks for diabetic retinopathy based on hypoxia-related genes: a bioinformatics analysis [PDF]
International Journal of OphthalmologyAIM: To prevent neovascularization in diabetic retinopathy (DR) patients and partially control disease progression. METHODS: Hypoxia-related differentially expressed genes (DEGs) were identified from the GSE60436 and GSE102485 datasets, followed by gene ...
Cai-Han Yu +5 more
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Frontiers in Immunology, 2023 BackgroundTo identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis.MethodsThe lipid metabolism-related hub genes were screened using machine learning algorithms, and the immune cell ...
Han She +18 more
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Hub gene target of glioblastoma: LOX, SERPINH1 and TGFBI
Medicine, 2022 Glioblastoma (GBM) is a malignant tumor. The long-term prognosis of the patients is poor. Therefore, it is of important clinical value to further explore the pathogenesis and look for molecular markers for early diagnosis and targeted treatment.
Shuyuan Zhang +7 more
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Frontiers in Immunology, 2022 BackgroundCalcific aortic valve disease (CAVD) is a progressive fibrocalcific disease that can be treated only through valve replacement. This study aimed to determine the role of hub genes and immune cell infiltration in CAVD progression.MethodsIn this ...
Kan Wang +5 more
doaj +1 more source
Prediction and analysis of osteoarthritis hub genes with bioinformatics
Annals of Translational Medicine, 2023 Osteoarthritis (OA) is the most common type of arthritis. OA can cause joint pain, stiffness, and loss of function. The pathogenesis of OA is not completely clear. Moreover, there is no effective treatment, and clinical management is limited to symptomatic relief or joint surgery.
Zhong, Junqing, Xiang, Ding, Ma, Xinlong
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Network Analyses of Differentially Expressed Genes in Osteoarthritis to Identify Hub Genes [PDF]
BioMed Research International, 2019 Background. Osteoarthritis (OA) is the most common degenerative disease in orthopedics. However, the cause and underlying molecular mechanisms are not clear. This study aims to identify the hub genes and pathways involved in the occurrence of osteoarthritis. Methods.
Zhaoyan Li +8 more
openaire +2 more sources
Identification and validation of hub genes for diabetic retinopathy
PeerJ, 2021 Background Diabetic retinopathy (DR) is characterized by a gradually progressive alteration in the retinal microvasculature that leads to middle-aged adult acquired persistent blindness. Limited research has been conducted on DR pathogenesis at the gene level.
Li Peng, Wei Ma, Qing Xie, Baihua Chen
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Identification of hub genes related to prognosis in glioma [PDF]
Bioscience Reports, 2020 Abstract Glioma, a common malignant tumor of the central nervous system, has high invasiveness. The objective of the present study was to identify genes playing an important role in the development of glioma and to reveal their potential research value.
Delong Zhang +5 more
openaire +2 more sources
Identification of Immune-Related Hub Genes in Parkinson’s Disease
Frontiers in Genetics, 2022 Background: Parkinson’s disease (PD) is a common, age-related, and progressive neurodegenerative disease. Growing evidence indicates that immune dysfunction plays an essential role in the pathogenic process of PD. The objective of this study was to explore potential immune-related hub genes and immune infiltration patterns of PD.Method: The microarray ...
Lin Chen +4 more
openaire +3 more sources
Discover Oncology, 2022 Prostate cancer (PCa) and benign prostate hyperplasia (BPH) are commonly encountered diseases in males. Studies showed that genetic factors are responsible for the occurrences of both diseases.
Xi Chen +9 more
doaj +1 more source