Results 71 to 80 of about 100,698 (279)

Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers

Scientific Reports, 2023
AbstractOsteoarthritis (OA) is a progressive cartilage degradation disease, concomitant with synovitis, osteophyte formation, and subchondral bone sclerosis. Over 37% of the elderly population is affected by OA, and the number of cases is increasing as the global population ages.
Junfeng Zeng, Xinhao Jiang, Mo Jiang, Yuexia Cao, Yi Jiang   +4 more
openaire   +3 more sources

One Hub-One Process: A Tool Based View on Regulatory Network Topology [PDF]

, 2007
The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based ...
Axelsen, Jacob Bock, Bernhardsson, Sebastian, Sneppen, Kim   +2 more
core   +4 more sources

Discovering new hub genes of dilated cardiomyopathy

ESC Heart Failure
AbstractAimsDilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.MethodsTwo gene
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
openaire   +3 more sources

Study of Osteoarthritis‐Related Hub Genes Based on Bioinformatics Analysis [PDF]

BioMed Research International, 2020
Osteoarthritis (OA) is a common cause of morbidity and disability worldwide. However, the pathogenesis of OA is unclear. Therefore, this study was conducted to characterize the pathogenesis and implicated genes of OA. The gene expression profiles of GSE82107 and GSE55235 were downloaded from the Gene Expression Omnibus database.
Zhengqing Zhu, Lei Zhong, Ronghang Li, Yuzhe Liu, Xiangrun Chen, Zhaoyan Li, Lanfeng Huang   +6 more
openaire   +2 more sources

A Genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology [PDF]

, 2015
We provide microarray data comparing genome-wide differential expression and pathology throughout life in four lines of "amyloid" transgenic mice (mutant human APP, PSEN1, or APP/PSEN1) and "TAU" transgenic mice (mutant human MAPT gene).
Ali, SS, Cummings, DM, Desai, R, Edwards, FA, Fulleylove, M, Guelfi, S, Hardy, J, Latcham, J, Liu, W, Matarin, M, Moens, TG, NahabooSolim, MA, Paublete, RM, Perona, M, Richardson, JC, Salih, DA, Smith, KJ, Yasvoina, M   +17 more
core  

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach

Scientific Reports, 2022
The primary objective of this investigation was to determine the hub genes of hepatocellular carcinoma (HCC) through an in silico approach. In the current context of the increased incidence of liver cancers, this approach could be a useful prognostic ...
Pradeep Kumar, Amit Kumar Singh, Kavindra Nath Tiwari, Sunil Kumar Mishra, Vishnu D. Rajput, Tatiana Minkina, Simona Cavalu, Ovidiu Pop   +7 more
doaj   +1 more source

Identification of featured necroptosis-related genes and imbalanced immune infiltration in sepsis via machine learning

Frontiers in Genetics, 2023
Background: The precise diagnostic and prognostic biological markers were needed in immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in sepsis, differentially expressed necroptosis-related genes (DE-NRGs) were ...
Han She, Han She, Lei Tan, Lei Tan, Ruibo Yang, Jie Zheng, Yi Wang, Yi Wang, Yuanlin Du, Xiaoyong Peng, Qinghui Li, Haibin Lu, Xinming Xiang, Yi Hu, Liangming Liu, Tao Li   +15 more
doaj   +1 more source

Backup machinery of yeast transcriptional regulatory network [PDF]

, 2008
Several studies have suggested the existence of backup machinery of transcriptional regulatory networks (TRNs). Here, we have quantified the backup machinery of yeast gene's TRNs under five different conditions in terms of alternate paths and have ...
Dhriti Sengupta, Sudip Kundu
core   +1 more source

Graph Theory and Networks in Biology [PDF]

, 2006
In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to ...
Mason, Oliver, Verwoerd, Mark
core   +3 more sources