Results 31 to 40 of about 4,526 (199)

Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice

Open Life Sciences, 2021
Mesenchymal stem cells (MSCs) can be obtained from almost all tissues and present promising therapeutic effects for metabolic diseases. Human adipose-derived MSCs (hASCs) have recently been widely studied due to their easy access and low immunity.
Xie Zongyan, Cheng Yu, Zhang Qi, Hao Haojie, Yin Yaqi, Zang Li, Wang Xuhong, Mu Yiming   +7 more
doaj   +1 more source

Chondrogenic potential of injectable κ-carrageenan hydrogel with encapsulated adipose stem cells for cartilage tissue-engineering applications [PDF]

, 2015
Due to the limited self-repair capacity of cartilage, regenerative medicine therapies for the treatment of cartilage defects must use a significant amount of cells, preferably applied using a hydrogel system that can promise their delivery and ...
Afizah, Ahmed, Augst, Awad, Aydelotte, Baeza, Bixler, Bosnakovski, Carvalho, Carvalho, Cohen, Crombrugghe, Drury, Erickson, Evans, Fisher, Gimble, Goldring, Gomes, Guilak, Hwang, Jen, Jung, Kara, Kisiday, Kisiday, Labarca, Lennart, Lin, Liski, Livak, Mangione, Mano, Marsich, Meunier, Miyata, Mueller, Naim, Nesic, Nettles, Oliveira, Prakash, Rada, Rada, Redman, Ronken, Salgado, Shoichet, Sipahigil, Sittinger, Slaughter, Spagnuolo, Stolz, Tapp, Tuli, Vallee, Varoni, Velleman, Wei, Zheng, Zscharnack, Zuk   +61 more
core   +1 more source

Downregulation of the protein synthesis machinery is a major regulatory event during early adipogenic differentiation of human adipose-derived stromal cells

Stem Cell Research, 2017
Commitment of adult stem cells involves the activation of specific gene networks regulated from transcription to protein synthesis. Here, we used ribosome profiling to identify mRNAs regulated at the translational level, through both differential ...
Bruna H. Marcon, Fabíola B. Holetz, Guillermo Eastman, Ana Carolina Origa-Alves, Mariana Andrea Amorós, Alessandra Melo de Aguiar, Carmen K. Rebelatto, Paulo R.S. Brofman, Jose Sotelo-Silveira, Bruno Dallagiovanna   +9 more
doaj   +1 more source

Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury [PDF]

, 2017
Damage to endothelial cells contributes to acute kidney injury (AKI) by causing impaired perfusion, while the permanent loss of the capillary network following AKI has been suggested to promote chronic kidney disease.
Basile, David P., Collett, Jason A., Crone, Allison, March, Keith L., Mehrotra, Purvi, Merfeld-Clauss, Stephanie, Traktuev, Dmitry O.   +6 more
core   +1 more source

Interleukin-8 Overexpressing Collagen Microgel-Based Cellular Microtissue Accelerates the Healing of Diabetic Foot Ulcers. [PDF]

Small
Collagen microgels (CMGs) incubated with cells self‐assemble into CMG‐based cellular microtissues (CCMs), enhancing cell adhesion and upregulating IL‐8 expression. A combinatorial strategy that integrates the CMG platform with IL‐8 overexpression promotes cell proliferation, migration, angiogenesis, and survival, thereby accelerating diabetic wound ...
Chung H, Jang WY, Choi JK, Kim SH.
europepmc   +2 more sources

Human adipose stem cells cell sheet constructs impact epidermal morphogenesis in full-thickness excisional wounds [PDF]

, 2013
Among the wide range of strategies to target skin repair/regeneration, tissue engineering (TE) with stem cells at the forefront, remains as the most promising route. Cell sheet (CS) engineering is herein proposed, taking advantage of particular cell-cell
A. M. Frias, A. P. Marques, A. R. Martins, Altman A. M., Altman A. M., Ananta M., Andreadis S. T., Aoki S., Chan R. K., D. B. Rodrigues, Dominici M., Ebrahimian T. G., Fu X., Gimble J. M., Guo L., Haraguchi Y., Iwata T., Kern S., Kim W. S., Kim W. S., Larouche D., Lee P. Y., Lin Y. C., Liu P., Liu S., Lugo L. M., M. T. Cerqueira, Maharlooei M. K., Martin P., Masuda S., Murad S., Natesan S., Nie C., Niemeyer P., Obokata H., Ohashi K., Okano T., Phinney D. G., Prockop D. J., R. L. Reis, R. P. Pirraco, Rehman J., Sekine H., Sekiya N., Singer A. J., Stephens F. O., Suh W., Sun G., T. C. Santos, Trottier V., Vermette M., Wearing H. J., Werner S., Wicke C., Wong V. W., Wong V. W., Wong V. W., Wu Y., Wu Y., Yamato M., Yang J., Yannas I. V.   +61 more
core   +1 more source

Transcriptional signature of human adipose tissue-derived stem cells (hASCs) preconditioned for chondrogenesis in hypoxic conditions

Experimental Cell Research, 2009
Hypoxia is an important factor involved in the control of stem cells. To obtain a better insight into the phenotypical changes brought about by hypoxic preconditioning prior to chondrogenic differentiation; we have investigated growth, colony-forming and chondrogenic capacity, and global transcriptional responses of six adipose tissue-derived stem cell
Pilgaard, Linda, Lund, Pia, Duroux, Meg, Lockstone, H., Taylor, J., Emmersen, Jeppe, Fink, Trine, Ragoussis, J., Zachar, Vladimir   +8 more
openaire   +3 more sources

Fabrication, Characterization, and Cytotoxicity of Thermoplastic Polyurethane/Poly(lactic acid) Material Using Human Adipose Derived Mesenchymal Stromal Stem Cells (hASCs) [PDF]

Polymers, 2018
Thermoplastic polyurethane (TPU) and poly(lactic acid) are types of biocompatible and degradable synthetic polymers required for biomedical applications. Physically blended (TPU+PLA) tissue engineering matrices were produced via solvent casting technique.
Lis-Bartos, Anna, Smieszek, Agnieszka, Frańczyk, Kinga, Marycz, Krzysztof   +3 more
openaire   +2 more sources

Natural assembly of platelet lysate-loaded nanocarriers into enriched 3D hydrogels for cartilage regeneration [PDF]

, 2015
The role of Platelet Lysates (PLs) as a source of growth factors (GFs) and as main element of threedimensional (3D) hydrogels has been previously described. However, the resulting hydrogels usually suffer from high degree of contraction, limiting their
Gomes, Manuela E., Mano, J. F., Popa, Elena Geta, Reis, R. L., Santo, Vitor E.   +4 more
core   +1 more source

Polycystin-2 mediates mechanical tension-induced osteogenic differentiation of human adipose-derived stem cells by activating transcriptional co-activator with PDZ-binding motif

Frontiers in Physiology, 2022
Human adipose-derived stem cells (hASCs) have multi-directional differentiation potential including osteogenic differentiation. Mechanical stimulation is thought to be a key regulator of bone remodeling and has been proved to promote osteogenic ...
Liang Wang, Liang Wang, Yahui Lu, Guanhui Cai, Hongyu Chen, Gen Li, Luwei Liu, Lian Sun, Zhaolan Guan, Wen Sun, Chunyang Zhao, Hua Wang   +11 more
doaj   +1 more source