Results 231 to 240 of about 111,766 (263)

Generation of Induced Pluripotent Stem Cells from Human Bone Marrow–Derived Mesenchymal Stem Cells

2021
Adult somatic cells can be reprogrammed and become pluripotent called induced pluripotent stem cells (iPSC) when they are induced by the stemness genes. The iPSCs have been representing a research and development platform for cell-based therapies, and even in gene editing technologies as they provide the ability to differentiate almost all cell types ...
Koyuncu Irmak, Duygu, Karaöz, Erdal
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Tissue-engineered bone formation with cryopreserved human bone marrow mesenchymal stem cells

Cryobiology, 2008
Bone marrow mesenchymal stem cells (MSCs) have become the main cell source for bone tissue engineering. It has been reported that cryopreserved human MSCs can maintain their potential for proliferation and osteogenic differentiation in vitro. There are, however, no reports on osteogenesis with cryopreserved human MSCs in vivo. The aim of this study was
Guangpeng, Liu, Chaofeng, Shu, Lei, Cui, Wei, Liu, Yilin, Cao   +4 more
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Effects of salinomycin on human bone marrow-derived mesenchymal stem cells in vitro

Toxicology Letters, 2013
Various hypotheses on the origin of cancer stem cells (CSCs) exist, including that CSCs develop from transformed human bone marrow mesenchymal stem cells (hBMSC). Since the polyether antibiotic salinomycin selectively kills CSCs, the present study aims to elucidate the effects of salinomycin on normal hBMSC.
A, Scherzed, S, Hackenberg, K, Froelich, K, Rak, A, Technau, A, Radeloff, U, Nöth, C, Koehler, R, Hagen, N, Kleinsasser   +9 more
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Knockdown of SIRT6 Enables Human Bone Marrow Mesenchymal Stem Cell Senescence

Rejuvenation Research, 2016
Autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation is a novel strategy for treating ischemic heart disease. However, limited benefits have been reported in aging patients. Rejuvenation of aged human BM-MSCs (hBM-MSCs) could be a means to improve the efficacy of stem cell transplantation in older patients. While it has been shown that
Xiao-Yan, Zhai, Ping, Yan, Jie, Zhang, Hui-Fang, Song, Wen-Juan, Yin, Hui, Gong, Hao, Li, Jun, Wu, Jun, Xie, Ren-Ke, Li   +9 more
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Identification of senescence-associated genes in human bone marrow mesenchymal stem cells

Biochemical and Biophysical Research Communications, 2008
Human bone marrow mesenchymal stem cells (hBMMSCs) are multipotent stem cells that can differentiate into several specialized cell types, including bone, cartilage, and fat cells. The proliferative capacity of hBMMSCs paves the way for the development of regenerative medicine and tissue engineering.
Eunsook, Ryu, Su, Hong, Jaeku, Kang, Junghoon, Woo, Jungjun, Park, Jongho, Lee, Jeong-Sun, Seo   +6 more
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Effect of Negative Pressure on Human Bone Marrow Mesenchymal Stem Cells In Vitro

Connective Tissue Research, 2010
The aim of this study was to determine how low-intensity intermittent negative pressure affects the differentiation and proliferation of human mesenchymal stem cells (MSCs), as well of OPG and OPGL mRNA expression in MSCs. MSCs were isolated from adult marrow using the density gradient separation method, passaged for three generations, and divided into
Yin-Gang, Zhang, Zhi, Yang, Hong, Zhang, Cunrong, Wang, Miao, Liu, Xiong, Guo, Peng, Xu   +6 more
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Human Fibroblasts Share Immunosuppressive Properties with Bone Marrow Mesenchymal Stem Cells

Journal of Clinical Immunology, 2010
Bone marrow mesenchymal stem cells (BM-MSCs) and adipose tissue-derived stem cells share immunosuppressive capacities, suggesting that the latter could be a general property of stromal cells.To check this hypothesis, we compared human BM-MSC and fibroblasts for their in vitro multi-potentiality, expandability and their immunomodulatory properties under
Sandrine, Cappellesso-Fleury, Bénédicte, Puissant-Lubrano, Pol-André, Apoil, Matthias, Titeux, Peter, Winterton, Louis, Casteilla, Philippe, Bourin, Antoine, Blancher   +7 more
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Isolation, differentiation, and characterization of mesenchymal stem cells from human bone marrow.

Gastroenterology and hepatology from bed to bench, 2017
We describe the minimum requirements and a simplified method for isolation and characterization of mesenchymal stem cells (MSCs) from human bone marrow.MSCs are well known adult stem cells present in many tissues such as adipocytes, chondrocytes, osteoblasts, and neurons.
Baghaei, Kaveh, Hashemi, Seyed Mahmoud, Tokhanbigli, Samaneh, Asadi Rad, Ali, Asadzadeh-Aghdaie, Hamid, Sharifian, Abdolhamid, Zali, Mohammad Reza   +6 more
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Integration potential of mouse and human bone marrow-derived mesenchymal stem cells

Differentiation, 2012
Mesenchymal stem cells (MSCs) are a multipotent cell population which has been described to exert renoprotective and regenerative effects in experimental models of kidney injury. Several lines of evidence indicate that MSCs also have the ability to contribute to nephrogenesis, suggesting that the cells can be employed in stem cell-based applications ...
Maria, Kuzma-Kuzniarska, Aleksandra, Rak-Raszewska, Simon, Kenny, David, Edgar, Bettina, Wilm, Cristina, Fuente Mora, Jamie A, Davies, Patricia, Murray   +7 more
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Transcriptional Regulation of Oct4 in Human Bone Marrow Mesenchymal Stem Cells

Stem Cells and Development, 2011
Oct4 is a key transcription factor to maintain self-renewal and undifferentiated state of embryonic stem cells. Site 2A located between -2,546 and -2,530 bp and site 2B between -2,500 and -2,486 bp of human Oct4 gene were shown to be sufficient for inducing Oct4 gene expression in embryonic stem cells.
Xing, Wei, Chong-Yang, Shen
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