Results 21 to 30 of about 192,493 (241)

Comparative Meta-Analysis of Carbohydrate Antigen 125 (CA125), Human Epididymis Protein 4 (HE4), and Diagnostic Indices (Risk of Malignancy Index (RMI) and Risk of Ovarian Malignancy Algorithm (ROMA)) for Pre-operative Detection of Ovarian Carcinoma. [PDF]

Cureus
Ovarian cancer remains a leading cause of gynecological cancer-related mortality, primarily due to late-stage diagnosis. Effective pre-operative differentiation between benign and malignant ovarian masses is crucial for improving patient outcomes.
Singh AK, Yadav P, Shukla M, Samaiya S, Singh S, Sorout S.   +5 more
europepmc   +2 more sources

Human epididymis protein 4 (HE4) in benign and malignant diseases [PDF]

Clinical Chemistry and Laboratory Medicine (CCLM), 2012
Background: Human epididymis protein 4 (HE4) is described as a useful new biomarker in ovarian cancer. As HE4 is neither tumor nor organ specific, we intensively investigated the occurrence of this protein in female and male patients with various benign ...
Anastasi, Anastasi, Andersen, Andersen, Bast, Bast, Drapkin, Drapkin, Duffy, Duffy, Escudero, Escudero, Galgano, Galgano, Heintz, Heintz, Hellstrom, Hellstrom, Hellstrom, Hellstrom, Holcomb, Holcomb, Huhtinen, Huhtinen, Jacob, Jacob, Jacobs, Jacobs, Kurman, Kurman, Liu, Liu, Montagnana, Montagnana, Moore, Moore, Nolen, Nolen, Tuxen, Tuxen   +39 more
core   +5 more sources

Increased serum human epididymis protein 4 is associated with disease activity and systemic involvement in pediatric-onset systemic lupus erythematosus. [PDF]

Front Immunol
Objective We aimed to investigate human epididymis protein 4 (HE4) as a potential biomarker in patients with pediatric-onset systemic lupus erythematosus (pSLE), particularly on the association of serum HE4 levels with disease activity and other ...
Liu C, Yan L, Zhang M, Duan Y, Luo J, Liu Z, Liu T, Tong J, Jiang Y.   +8 more
europepmc   +2 more sources

Significantly elevated serum human epididymis protein-4 in chronic kidney disease patients without ovarian cancer: A large-scale retrospective study. [PDF]

J Clin Lab Anal, 2023
Human epididymis protein‐4 (HE‐4) is a commonly used biomarker for diagnosing ovarian cancer. Elevated HE‐4 has also been observed in various benign conditions including chronic kidney disease (CKD); however, generalizability and statistical power of ...
Yan S, Lin Y, Tian X.
europepmc   +2 more sources

The diagnostic value of human epididymis protein 4 for endometrial cancer is moderate [PDF]

Scientific Reports, 2021
Human epididymis protein 4 (HE4) has been used as a biomarker of endometrial cancer (EC) in clinical practice. However, there remains a lack of systemic research on the critical values of HE4 for diagnosing different clinical stages and pathological ...
Jing Liu, Lili Han, Zhen Jiao
doaj   +2 more sources

Comparison of Human Epididymis Protein 4, Cancer Antigen 125, and Ultrasound Prediction Model in Differentiating Benign from Malignant Adnexal Masses. [PDF]

J Midlife Health, 2023
Background: This study aimed to compare the diagnostic performance of carcinogenic antigen (CA) 125, (HE)-4 (Human epididymis protein 4), and ultrasound (International Ovarian Tumor Analysis [IOTA]) Simple Rules individually and to derive a composite ...
Bahadur A, Bhattacharya N, Mundhra R, Khoiwal K, Chawla L, Singh R, Naithani M, Kishore S.   +7 more
europepmc   +2 more sources

Advances of Human Epididymis Protein 4 in Lung Cancer

Chinese Journal of Lung Cancer, 2015
Human epididymis 4 (HE4) belongs to whey acidic 4-disulfide center protein family. It has the characteristics of inhibiting trypsin and high expression in the serum or malignant pleural effusion of patients with lung cancer.
Qing MA, Qian WANG, Diansheng ZHONG
doaj   +3 more sources

Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population [Retraction] [PDF]

Diabetes, Metabolic Syndrome and Obesity, 2021
Tan S, Zeng Y, Kuang S, Li J. Diabetes Metab Syndr Obes. 2021;14:1601–1608. The Editor and Publisher of Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy wish to retract the published article.
Tan S, Zeng Y, Kuang S, Li J
doaj   +2 more sources

Multiple biomarkers are more accurate than a combination of carbohydrate antigen 125 and human epididymis protein 4 for ovarian cancer screening. [PDF]

Obstet Gynecol Sci, 2022
Objective The objective of this study was to compare and evaluate the diagnostic value of serum carbohydrate antigen 125 (CA125) and/or human epididymis protein 4 (HE4) and a panel of novel multiple biomarkers in patients with ovarian tumors to identify ...
Kang KN, Koh EY, Jang JY, Kim CW.
europepmc   +2 more sources

Elevated serum human epididymis protein 4 is associated with disease severity and worse survival in idiopathic pulmonary fibrosis: a cohort study. [PDF]

Ann Transl Med, 2022
Background Elevated expression of human epididymis protein 4 (HE4) was previously described in connective tissue disease-associated interstitial lung diseases (CTD-ILDs) and cystic fibrosis (CF), but the clinical significance of HE4 has remained unknown ...
Tian M, Meng K, Gao Y, Zhang J, Xie M, Tian Y, Liu X, Ma M, Cai Y, Wu H, Ding J, Chen J, Cai H.   +12 more
europepmc   +2 more sources