Results 71 to 80 of about 4,794,580 (401)

Digital Transformation: Challenges for Human Resources Management

ENTRENOVA - ENTerprise REsearch InNOVAtion, 2021
The global economic situation and need to be better prepared for competitive challenges put pressure on modern companies to shift toward automation and digitalization.
A. Barisic, Joanna Rybacka Barišić, I. Miloloza   +2 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Methodological approach to management and development of human resources [PDF]

, 2019
The proposed methodological approach to the management and development of human resources formalizes and visualizes the possible forms of management decision-making for any person, family, company, city, country, and the world as a whole, based on the ...
S. Sardak, V. Fisheliev, Sardak, Sergii
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Perceptions of the dimensions of the fairness of affirmative action: A pilot study

South African Journal of Business Management, 2006
The purpose of this study was to identify the dimensions of affirmative action (AA) fairness in order to develop a valid and reliable questionnaire to assess employees’ perceptions of the fairness of AA decisions and practices, and to explore the ...
L. P. Vermeulen, M. Coetzee
doaj   +1 more source

A review paper on artificial intelligence at the service of human resources management

Indonesian Journal of Electrical Engineering and Computer Science, 2020
In the last few years, all companies have been interested in the analysis of data related to Human Resources and have focused on human capital, which is considered as the major factor influencing the company’s development and all its activities at all ...
Siham Berhil, H. Benlahmar, N. Labani
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Multigenerational human resources’ management

Journal of Modern Science
This paper indicates significance of generational diversity management in modern business. Due to certain social, political and economic circumstances each generation is specific, with its own skills, interactions and expectations. What is common for all
Aleksandra Ewa Krawczyk
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Human resources management value in knowledge-based society

Business: Theory and Practice, 2009
While building knowledge-based society and economy, particular importance in human resources management falls on the value of human resources and management expertise.
Liudmila Lobanova
doaj