Results 81 to 90 of about 4,794,580 (401)

Medication adherence among the elderly: applying grounded theory approach in a developing country

open access: yesJournal of Pharmaceutical Policy and Practice, 2021
Background Medication adherence is an important concept particularly among the elderly that can, directly and indirectly, affect the health system’s costs and the elderly’s health, quality of life, and functional abilities.
Peivand Bastani   +6 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Personality attributes of successful franchisees in the fast foods sector in South Africa

open access: yesSouth African Journal of Economic and Management Sciences, 2002
The aim of the study was to identify the personality traits, emotive responses and attitudinal orientation of franchisees. Cattell's 16 Personality Factor Questionnaire, the Personal Profile Analysis of Thomas International and Boshoff's Entrepreneurial ...
B. von H Kasselmann   +2 more
doaj   +1 more source

Designing a resilience model for pharmaceutical supply chain during crises: a grounded theory approach

open access: yesJournal of Pharmaceutical Policy and Practice, 2021
Background During disasters or crises, the traditional models of supply chain encounter failure and skewedness under the inevitable and unknown pressures. The procurement and transformation of required equipment to the involved areas is considered as one
Peivand Bastani   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Gendered health care labour markets? A case study of anatomical pathologists and haematologists in KwaZulu-Natal, South Africa

open access: yesThe Journal for Transdisciplinary Research in Southern Africa, 2016
This study qualitatively explored the role of gender and related factors that influence medical doctors’ decisions in selecting a specialisation within medical laboratory medicine.
Suveera Singh, Shaun Ruggunan
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Strategic Model of E-Business Performance [PDF]

open access: yesمطالعات مدیریت راهبردی, 2020
The most important purpose of this study is to investigate the factors affecting the implementation of the strategy and its impact on the performance of electronic businesses in the form of a conceptual model and its testing.
soltanali shahriari   +2 more
doaj  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

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