Results 111 to 120 of about 33,531 (157)

The biology and expression of huntingtin interacting protein 14

, 2011
Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington Disease. HIP14 palmitoylates a specific set of neuronal substrates critical at the synapse, and downregulation of HIP14 by siRNA in vitro results in increased
openaire   +2 more sources

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays. [PDF]

Brain Commun
Landles C, Osborne GF, Phillips J, Canibano-Pico M, Nita IM, Ali N, Bobkov K, Greene JR, Sathasivam K, Bates GP.   +9 more
europepmc   +1 more source

Chemical mutagenesis of Caenorhabditis elegans uncovers genetic modifiers of huntingtin protein aggregation. [PDF]

MicroPubl Biol, 2020
Ung H, Hall R, Kikis E.
europepmc   +1 more source

Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein. [PDF]

ACS Chem Neurosci
Zhang Z, Gehin C, Abriata LA, Dal Peraro M, Lashuel H.   +4 more
europepmc   +1 more source

A method for the analysis of the oligomerization profile of the Huntington's disease-associated, aggregation-prone mutant huntingtin protein by isopycnic ultracentrifugation. [PDF]

Front Mol Biosci
Bonavita R, Di Martino R, Cortone G, Prodomo A, Di Gennaro M, Scerra G, Panico V, Nuzzo S, Salvatore M, Williams SV, Vitale F, Caporaso MG, D'Agostino M, Pisani FM, Fleming A, Renna M.   +15 more
europepmc   +1 more source

Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt. [PDF]

Biochemistry, 2020
Arndt JR, Chaibva M, Beasley M, Kiani Karanji A, Ghassabi Kondalaji S, Khakinejad M, Sarver O, Legleiter J, Valentine SJ.   +8 more
europepmc   +1 more source

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis. [PDF]

Proc Natl Acad Sci U S A
Sun X, Liu L, Wu C, Li X, Guo J, Zhang J, Guan J, Wang N, Gu L, Yang XW, Li GM.   +10 more
europepmc   +1 more source

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers [PDF]

, 2018
Aimin Li, Ammon E. Posey, Kiersten M. Ruff, Marc I. Diamond, Rohit V. Pappu, Scott L. Crick, Tyler S. Harmon   +6 more
core   +2 more sources

High Levels of Mutant Huntingtin Protein in Tear Fluid From Huntington's Disease Gene Expansion Carriers. [PDF]

J Mov Disord
Gijs M, Jorna N, Datson N, Beekman C, Dansokho C, Weiss A, Linden DEJ, Oosterloo M.   +7 more
europepmc   +1 more source

Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses. [PDF]

Front Immunol, 2019
Lin YH, Maaroufi HO, Ibrahim E, Kucerova L, Zurovec M.   +4 more
europepmc   +1 more source