Results 151 to 160 of about 19,301 (228)

Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis. [PDF]

Proc Natl Acad Sci U S A
Sun X, Liu L, Wu C, Li X, Guo J, Zhang J, Guan J, Wang N, Gu L, Yang XW, Li GM.   +10 more
europepmc   +1 more source

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex [PDF]

, 2016
Tamara Maiuri, Andrew J. Mocle, Claudia Lin-Kar Hung, Jianrun Xia, Willeke van Roon‐Mom, Ray Truant   +5 more
openalex   +1 more source

High Levels of Mutant Huntingtin Protein in Tear Fluid From Huntington's Disease Gene Expansion Carriers. [PDF]

J Mov Disord
Gijs M, Jorna N, Datson N, Beekman C, Dansokho C, Weiss A, Linden DEJ, Oosterloo M.   +7 more
europepmc   +1 more source

Transneuronal propagation of mutant huntingtin protein [PDF]

Nature Reviews Neurology, 2014
openaire   +1 more source

Huntingtin Interacting Protein 1 Induces Apoptosis via a Novel Caspase-dependent Death Effector Domain

, 2000
Abigail S. Hackam, Ayman S. Yassa, Roshni R. Singaraja, Martina Metzler, Claire-Anne Gutekunst, Lu Gan, Simon C. Warby, Cheryl L. Wellington, John P. Vaillancourt, Nansheng Chen, François G. Gervais, Lynn A. Raymond, Donald W. Nicholson, Michael R. Hayden   +13 more
openalex   +1 more source

Super-resolution fluorescence imaging of intracellular mutant huntingtin protein reveals a population of fibrillar aggregates co-existing with compact perinuclear inclusion bodies [PDF]

, 2013
Steffen J. Sahl, Lucien E. Weiss, Lana Lau, Judith Frydman, WE Moerner   +4 more
openalex   +1 more source

Expression of Human Mutant Huntingtin Protein in Drosophila Hemocytes Impairs Immune Responses. [PDF]

Front Immunol, 2019
Lin YH, Maaroufi HO, Ibrahim E, Kucerova L, Zurovec M.   +4 more
europepmc   +1 more source

Additional file 1 of Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice

Oraha, Jennifer, Wagner, Ronja, Bergh, Sofia, Lee, Nicola J, Kirik, Deniz, Petersén, Åsa   +5 more
openalex   +1 more source

Design and characterisation of mutant and wild-type huntingtin proteins produced from a toolkit of scalable eukaryotic expression systems [PDF]

, 2018
Rachel Harding, P. Loppnau, Suzanne Ackloo, Alexander Lemak, Ashley Hutchinson, Brittany Hunt, Alex S. Holehouse, Jolene Caifeng Ho, Lixin Fan, Leticia Toledo‐Sherman, Alma Seitova, C.H. Arrowsmith   +11 more
openalex   +1 more source

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein. [PDF]

Elife, 2017
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.   +20 more
europepmc   +1 more source