Results 171 to 180 of about 52,129 (204)
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A Study of Potential Interactive Genetic Factors in Huntington’s Disease
European Neurology, 2006<i>Aim:</i> To assess the role of genetic factors, other than the CAG repeat length, on the development of Huntington’s disease (HD) in an isolated Caucasian population in the south-west of Western Australia. <i>Methods:</i> 114 patients with symptomatic HD according to the Unified HD Rating Scale research criteria were examined
Panegyres, Peter K +4 more
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The disparate effects of Alzheimer's disease and Huntington's disease on semantic memory.
Neuropsychology, 1999Alzheimer's disease (AD) and Huntington's disease (HD) impair performance on semantic memory tasks, but researchers disagree on whether AD and HD cause these impairments in the same manner. According to one view, AD disrupts the storage of semantic memories, whereas HD disrupts the retrieval of semantic memories.
Rohrer, Doug +3 more
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Understanding the Role of Protein Kinase C and Striatum Development in Huntington’s Disease
2021Huntington’s Disease (HD) is a neurodegenerative disorder caused by a CAG expansion within exon 1 of the huntingtin gene. The mutated HTT (mHTT) protein aggregates and is proteolytically cleaved, forming toxic fragments of the protein that disrupt cellular homeostasis.
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Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Science Translational Medicine, 2018Mutant huntingtin suppression with antisense oligonucleotides reverses cognitive impairments in a mouse model of Huntington’s disease.
Amber L. Southwell +18 more
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Modulating Matrix Metalloproteases and Inflammation in Huntington’s Disease
2020Huntington’s disease (HD) is a rare and incurable autosomal neurodegenerative disease affecting 1-10 in every 100,000 people in the world. There is no cure for HD and treatments available alleviate certain symptoms for short periods of time. Evidence suggests that neuropathology of HD begins with the proteolysis of the mutated Huntingtin (mHTT ...
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Physiotherapy Theory and Practice, 2016
Given the neurodegenerative nature of Huntington's disease (HD), community-based exercise programs that meet the ongoing needs of those living with HD are needed. The genetic nature of HD warrants the inclusion of those at-risk for HD. The purpose of this clinical report is to describe an evidence-based approach to the design of a community-based ...
Clark, Dalie +2 more
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Given the neurodegenerative nature of Huntington's disease (HD), community-based exercise programs that meet the ongoing needs of those living with HD are needed. The genetic nature of HD warrants the inclusion of those at-risk for HD. The purpose of this clinical report is to describe an evidence-based approach to the design of a community-based ...
Clark, Dalie +2 more
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Calcium Channel Dysfunction in Huntington’s Disease
2017Huntington’s disease (HD) is an autosomal dominant degenerative disease that is caused by an expansion mutation in the huntingtin protein that lengthens a naturally occurring trinucleotide CAG repeat in exon 1 resulting in striatal degeneration. The mechanism by which striatal neurons undergo selective degeneration is not fully understood, although ...
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European Journal of Neuroscience, 2009
AbstractEmbryonic striatal grafts integrate with the host striatal circuitry, forming anatomically appropriate connections capable of influencing host behaviour. In addition, striatal grafts can influence host behaviour via a variety of non‐specific, trophic and pharmacological mechanisms; however, direct evidence that recovery is dependent on circuit ...
Mazzocchi-Jones, David M. +2 more
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AbstractEmbryonic striatal grafts integrate with the host striatal circuitry, forming anatomically appropriate connections capable of influencing host behaviour. In addition, striatal grafts can influence host behaviour via a variety of non‐specific, trophic and pharmacological mechanisms; however, direct evidence that recovery is dependent on circuit ...
Mazzocchi-Jones, David M. +2 more
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Determining the Molecular Mechanisms of Huntington
2017Huntington’s disease (HD) is associated with a mutational CAG repeat expansion within exon 1 of the huntingtin (Htt) gene. Post-transcriptional processing leads to the generation of N-terminal Htt protein fragments (Htt-NTFs), including those that encompass exon 1 (Httex1).
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