Results 171 to 180 of about 93,886 (309)

Physiotherapy in Huntington’s disease

Fysioterapeuten, 2013
Introduction:Huntington’s disease is hereditary and causes motor, cognitive and behavioural symptoms that progress over time. The aim of this article is to describe the disease and to highlight why physiotherapy is important and to point out potential ...
Hanne Ludt Fossmo, Anu Piira, Jeanette Ullmann Miller, Jan C. Frich   +3 more
doaj  

Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington’s disease mice

Translational Neurodegeneration
Background Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in clinical trials.
Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden   +13 more
doaj   +1 more source

Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites [PDF]

, 2019
Amanda J. Kedaigle, Ernest Fraenkel, Ranjit Singh Atwal, Min Wu, James F. Gusella, Marcy E. MacDonald, Julia Kaye, Steven Finkbeiner, Virginia B. Mattis, Colton M. Tom, Clive N. Svendsen, Alvin R. King, Yumay Chen, Jennifer Stocksdale, Ryan G. Lim, Malcolm Casale, Ping H. Wang, Leslie M. Thompson, Sergey Akimov, Tamara Ratovitski, Nicolas Arbez, Christopher A. Ross   +21 more
openalex   +1 more source

Single case-control design for the study of the neuropsychological deficits and dissociations in Huntington’s disease-like 2 [PDF]

, 2020
Aline Ferreira‐Correia, David G. Anderson, Kate Cockcroft, Amanda Krause   +3 more
openalex   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

Automatic selection model to identify neurodegenerative diseases

Digital Health
Objective This study evaluates machine learning algorithms’ effectiveness in classifying Parkinson’s disease and Huntington’s disease based on biomarker data obtained non-invasively from patients and healthy controls.
Eddy Sánchez-DelaCruz, Cecilia-Irene Loeza-Mejía, César Primero-Huerta, Mirta Fuentes-Ramos   +3 more
doaj   +1 more source

Attentional compensation in neurodegenerative diseases: the model of premanifest Huntington’s disease mutation carriers [PDF]

, 2020
Lorna Le Stanc, Marine Lunven, Maria Giavazzi, Agnès Sliwinski, Pierre Brugières, Katia Youssov, Anne‐Catherine Bachoud‐Lévi, Charlotte Jacquemot   +7 more
openalex   +1 more source

Preoperative Functional Connectivity Predicts Antiparkinson Drug Change after Deep Brain Stimulation

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) can effectively ameliorate motor symptoms in Parkinson's disease (PD), but patient outcomes remain variable. Clinical predictors lack reliability and only explain a small proportion of outcome variance, outlining a need for biomarkers that can enhance prediction accuracy.
David Mikhael, Skyler Deutsch, Juhi Mehta, Sarah Wang, John Kornak, Philip A. Starr, Jill L. Ostrem, Doris D. Wang, Ian O. Bledsoe, Melanie A. Morrison   +9 more
wiley   +1 more source

Predictive testing for Huntington’s disease in a digital age; patient power with potential pitfalls [PDF]

Valentin Mocanu, SG Lindquist, LE Hjermind, Jörg Heilmann, Rhona MacLeod, Nayana Lahiri   +5 more
openalex   +1 more source

Interplay Between Sex and Cytosine‐Adenine‐Guanine‐Age Product Score in Huntington's Disease: Clinical and Neuroimaging Perspectives

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a cytosine‐adenine‐guanine (CAG) repeat expansion in the huntingtin gene. The disease exhibits sex‐related differences in symptomatology and disease progression, but the effect on brain structural biomarkers and the interaction between sex and CAG‐age ...
Jingwen Yao, Grayson Feng, Guowen Shao, Zexi Wang, Adys Mendizabal, Donatello Telesca, Kaiying Fang, Lola Ibragimova, Juwairia Shoaib, Melanie A. Morrison, Janine M. Lupo   +10 more
wiley   +1 more source