Huperzine A Regulates the Physiological Homeostasis of Amyloid Precursor Protein Proteolysis and Tau Protein Conformation-A Computational and Experimental Investigation. [PDF]
Biology (Basel)Wongjaikam S +6 more
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The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories. [PDF]
J XenobiotVanhee C +18 more
europepmc +1 more source
Evaluation of the Alkaloids as Inhibitors of Human Acetylcholinesterase by Molecular Docking and ADME Prediction. [PDF]
In VivoNegru DC +6 more
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Microbial transformation of (−)-Huperzine A
Tetrahedron Letters, 2010Five products were yielded from the transformation of (−)-Huperzine A (1) by Streptomyces griseus CACC 200300. Their structures were determined as 16-hydroxyl huperzine A (2), 14α-hydroxyl huperzine A (3), huperzine A 8α,15α-epoxide (4), 13N-formyl huperzine A (5), and 13N-acetyl huperzine A (6) on the basis of their chemical and physical data.
Jungui Dai
exaly +2 more sources
An update on huperzine A as a treatment for Alzheimer's disease
Expert Opinion on Investigational Drugs, 2008Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata. There is evidence that huperzine A may compare favorably in symptomatic efficacy to cholinesterase inhibitors in use. In addition, huperzine A has antioxidant and neuroprotective properties that suggest that it may be useful as a disease-modifying ...
Paul S Aisen
exaly +3 more sources
Divergent Total Synthesis of the Lycopodium Alkaloids Huperzine A, Huperzine B, and Huperzine U
The Journal of Organic Chemistry, 2013Huperzine A, huperzine B, and huperzine U are congeners isolated from the Chinese herb Huperzia serrata (= Lycopodium serratum ) in minuscule amounts. The most efficient total synthesis of huperzine A, the first asymmetric total syntheses of huperzine B, and the first total synthesis of huperzine U have been achieved efficiently in overall yields of 17%
Rui, Ding +4 more
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Huperzine A for Alzheimer's disease
Internal Medicine News, 2006Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD.
J, Li +4 more
openaire +3 more sources
Total Synthesis of (−)-Huperzine A
Organic Letters, 2009The total synthesis of huperzine Q was accomplished. The synthesis features the construction of the cis-hydrindane skeleton via a Diels-Alder reaction and a ring contraction reaction of an epoxyketone.
Toshimune Nomura +2 more
openaire +4 more sources
Synthesis of a hybrid analog of the acetylcholinesterase inhibitors huperzine A and huperzine B
Tetrahedron Letters, 2001Abstract The synthesis of a new hybrid analog of the acetylcholinesterase (AChE) inhibitors huperzine A and B is reported. An intramolecular reductive dicarbonyl coupling was used as a key reaction for constructing the tetracyclic ring system.
V Rajendran +4 more
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A Convergent Approach to Huperzine A and Analogues.
ChemInform, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Seán A, Kelly +3 more
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