Results 71 to 80 of about 4,132 (213)
A drug screening toolkit based on the –1 ribosomal frameshifting of SARS-CoV-2
Heliyon, 2020 The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus.
Yanqiong Chen +8 more
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Synthetic approaches towards the Lycopodium alkaloids [PDF]
, 2014 Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704The Lycopodium alkaloids are a structurally diverse group of natural products isolated from Lycopodium with important biological effects for the potential treatment of cancer and severe
Balañà, Marta +4 more
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Current Issues in Molecular Biology, 2021 The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is an ...
Hafsa Amat-ur-Rasool +4 more
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Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
ChemistryEurope, Volume 3, Issue 4, July 14, 2025.This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley +1 more source
Synthetic biology for medical biomaterials
Interdisciplinary Medicine, Volume 3, Issue 4, July 2025.Synthetic biology platform has been utilized to produce a variety of medical biomaterials (MBMs), such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), hyaluronic acid (HA), collagen (COL), poly(β‐malic acid) (PMLA), poly‐γ‐glutamic acid (γ‐PGA), alginate (ALG), chitosan (CS), bacterial cellulose (BC), and antimicrobial peptides (AMPs).
Tao Xu +4 more
wiley +1 more source
Molecules, 2018 In order to explore the potential therapeutic effect of Xanthoceras sorbifolia Bunge. against Alzheimer’s disease, an HPLC-MS/MS method has been developed and validated for simultaneous determination in rat brain of eight neurotransmitters ...
Zheng Sun, Qing Li, Kaishun Bi
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The Role of Natural Products in Pharmacotherapy of Alzheimer’s Disease [PDF]
, 2005 Alzheimer’s disease is characterized by forgetfulness, disturbance in memory and loss of mental abilities. The final outcome of the disease is loss of personality and intellectual functions.
Singh, Amrit Pal
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Natural Products in Epilepsy—the Present Situation and Perspectives for the Future [PDF]
, 2014 More efficacious and better tolerated treatments for epilepsy are clearly needed. Complementary and alternative medicine (CAM) has a long history of use in certain parts of the world and has gained increasing interest over the last decades in Western ...
Ekstein, Dana, Schachter, Steven C.
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Alzheimer's &Dementia, Volume 21, Issue 6, June 2025.Abstract INTRODUCTION Diet plays a critical role in the prevention and treatment of cognitive impairment, yet dietary intake in patients with cognitive impairment in China remains insufficiently studied. METHODS A 25‐item semi‐quantitative food frequency questionnaire was used in a national online survey in China.
Dongsheng Bian +32 more
wiley +1 more source
Cognitive performance of healthy young rats following chronic donepezil administration. [PDF]
, 2008 RATIONALE: Experimental studies have investigated the effects of chronic donepezil treatment on the behavioral deficits elicited by reduced activity or the loss of cholinergic neurons that occurs in aging or in models of dementia. However, few studies
Bartolo, P. DE +6 more
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