Results 1 to 10 of about 87,484 (183)

4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression [PDF]

Cells, 2022
Radioresistant (RR) cells are poor prognostic factors for tumor recurrence and metastasis after radiotherapy. The hyaluronan (HA) synthesis inhibitor, 4-methylumbelliferone (4-MU), shows anti-tumor and anti-metastatic effects through suppressing HA ...
Kazuki Hasegawa, Ryo Saga, Kentaro Ohuchi, Yoshikazu Kuwahara, Kazuo Tomita, Kazuhiko Okumura, Tomoaki Sato, Manabu Fukumoto, Eichi Tsuruga, Yoichiro Hosokawa   +9 more
doaj   +3 more sources

Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy [PDF]

Cancer Medicine, 2019
Neuroblastoma is the second most common pediatric malignancy and has a high rate of spontaneous remission. Uncovering the mechanisms underlying neuroblastoma cell differentiation is critical for therapeutic purposes.
Wen‐Jui Lee, Li‐Ching Chen, Juo‐Han Lin, Tzu‐Chun Cheng, Ching‐Chuan Kuo, Chih‐Hsiung Wu, Hui‐Wen Chang, Shih‐Hsin Tu, Yuan‐Soon Ho   +8 more
doaj   +3 more sources

Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration [PDF]

Frontiers in Immunology
IntroductionAbdominal aortic aneurysms and dissections (AAA/AD) are vascular disorders with high mortality due to aortic ruptures. Critical pathomechanisms involve immune cell infiltration and degradation of the vascular extracellular matrix (ECM ...
Viola Niemann, Fedor Brack, Luca Rolauer, Janet Kaczur, Patrick Petzsch, Karl Köhrer, Christine Quast, Norbert Gerdes, Norbert Gerdes, Pascal Bouvain, Katharina Voigt, Martina Krüger, Martina Krüger, Alexander Brückner, Bernd K. Fleischmann, Daniela Wenzel, Daniela Wenzel, Philipp Barnowski, Philipp Barnowski, Philipp Barnowski, Philipp Barnowski, Philipp Barnowski, Laura-Marie Zimmermann, Laura-Marie Zimmermann, Laura-Marie Zimmermann, Laura-Marie Zimmermann, Laura-Marie Zimmermann, Sakine Simsekyilmaz, Timm Filler, Wiebke Ibing, Tobias Feige, Kim J. Krott, Markus U. Wagenhäuser, Jens W. Fischer, Jens W. Fischer, Margitta Elvers, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Ulrich Flögel, Ulrich Flögel, Christian Hundhausen, Tatsiana Suvorava, Maria Grandoch, Maria Grandoch   +46 more
doaj   +3 more sources

Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model [PDF]

International Journal of Cell Biology, 2015
Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the ...
Sean P. Kessler, Dana R. Obery, Carol de la Motte   +2 more
doaj   +3 more sources

Hydrocellular foam dressing promotes wound healing along with increases in hyaluronan synthase 3 and PPARα gene expression in epidermis. [PDF]

PLoS ONE, 2013
BackgroundHydrocellular foam dressing, modern wound dressing, induces moist wound environment and promotes wound healing: however, the regulatory mechanisms responsible for these effects are poorly understood. This study was aimed to reveal the effect of
Takumi Yamane, Gojiro Nakagami, Sawako Yoshino, Aimi Muramatsu, Sho Matsui, Yuichi Oishi, Toshiki Kanazawa, Takeo Minematsu, Hiromi Sanada   +8 more
doaj   +3 more sources

CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. [PDF]

Pediatr Res, 2022
Continuous positive airway pressure (CPAP) is a primary mode of respiratory support for preterm infants. Animal studies have shown long-term detrimental effects on lung/airway development, particularly airway (AW) hyper-reactivity, as an unfortunate ...
Mayer CA, Ganguly A, Mayer A, Pabelick CM, Prakash YS, Hascall VC, Midura RJ, Cali V, Flask CA, Erokwu BO, Martin RJ, MacFarlane PM.   +11 more
europepmc   +2 more sources

A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. [PDF]

Int J Mol Sci, 2022
Hyaluronan (HA), an essential component of the extracellular matrix of the skin, is synthesized by HA synthases (HAS1-3). To date, epidermal HA has been considered a major player in regulating cell proliferation and differentiation.
Ota Y, Yoshida H, Endo Y, Sayo T, Takahashi Y.   +4 more
europepmc   +2 more sources

Platelet Hyaluronan Synthase 3 Regulates Thrombin Signaling and Adhesion to Fibrinogen Under Venous Shear. [PDF]

Proteoglycan Res
Hyaluronan (HA) is an essential glycosaminoglycan with supportive roles in hematopoiesis. HA is synthesized by hyaluronan synthases (HAS1, HAS2, and HAS3) and plays a crucial role in cellular signaling and extracellular matrix interactions ...
Queisser KA, Smith L, Leung G, Albtoush N, Mellema RA, Petrey AC.   +5 more
europepmc   +2 more sources

Hyaluronan synthase 3 mediated oncogenic action through forming inter-regulation loop with tumor necrosis factor alpha in oral cancer. [PDF]

Oncotarget, 2017
Hyaluronan (HA) is a major extracellular matrix component. However, its role and mediation in oral cancer remains elusive. Hyaluronan synthase 3 (HAS3), involved in pro-inflammatory short chain HA synthesis, was the predominant synthase in oral cancer ...
Kuo YZ, Fang WY, Huang CC, Tsai ST, Wang YC, Yang CL, Wu LW.   +6 more
europepmc   +2 more sources

Differential effects of hyaluronan synthase 3 deficiency after acute vs chronic liver injury in mice. [PDF]

Fibrogenesis Tissue Repair, 2016
BackgroundHyaluronan (HA) is a ubiquitous extracellular matrix (ECM) glycosaminoglycan synthesized by three different enzymes, hyaluronan synthase (HAS)1, 2, and 3. HA synthesis mediated by HAS3 promotes inflammation and is pathogenic in animal models of
McCracken JM, Jiang L, Deshpande KT, O'Neil MF, Pritchard MT.   +4 more
europepmc   +2 more sources