Results 11 to 20 of about 87,553 (215)

Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. [PDF]

Biomed Res Int, 2014
Extensive accumulation of the glycosaminoglycan hyaluronan is found in pancreatic cancer. The role of hyaluronan synthases 2 and 3 (HAS2, 3) was investigated in pancreatic cancer growth and the tumor microenvironment.
Kultti A, Zhao C, Singha NC, Zimmerman S, Osgood RJ, Symons R, Jiang P, Li X, Thompson CB, Infante JR, Jacobetz MA, Tuveson DA, Frost GI, Shepard HM, Huang Z.   +14 more
europepmc   +6 more sources

Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues [PDF]

Molecules, 2021
The microenvironment for tumor growth and developing metastasis should be essential. This study demonstrated that the hyaluronic acid synthase 3 (HAS3) protein and its enzymatic product hyaluronic acid (HA) encompassed in the subcutaneous extracellular ...
Wen-Jui Lee, Shih-Hsin Tu, Tzu-Chun Cheng, Juo-Han Lin, Ming-Thau Sheu, Ching-Chuan Kuo, Chun A. Changou, Chih-Hsiung Wu, Hui-Wen Chang, Hang-Lung Chang, Li-Ching Chen, Yuan-Soon Ho   +11 more
doaj   +4 more sources

Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3. [PDF]

J Biol Chem
Hyaluronan (HA) is a high-molecular-weight (HMW) glycosaminoglycan, which is a fundamental component of the extracellular matrix that is involved in a variety of biological processes. We previously showed that the HYBID/KIAA1199/CEMIP axis plays a key role in the depolymerization of HMW-HA in normal human dermal fibroblasts (NHDFs).
Abe M, Masuda M, Mizukami Y, Inoue S, Mizutani Y.   +4 more
europepmc   +5 more sources

Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. [PDF]

Matrix Biol, 2018
Hyaluronan (HA) is a prominent component of the provisional extracellular matrix (ECM) present in the neointima of atherosclerotic plaques. Here the role of HA synthase 3 (HAS3) in atheroprogression was studied.It is demonstrated here that HAS isoenzymes 1, -2 and -3 are expressed in human atherosclerotic plaques of the carotid artery.
Homann S, Grandoch M, Kiene LS, Podsvyadek Y, Feldmann K, Rabausch B, Nagy N, Lehr S, Kretschmer I, Oberhuber A, Bollyky P, Fischer JW.   +11 more
europepmc   +5 more sources

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice. [PDF]

Arterioscler Thromb Vasc Biol, 2016
Objective— Hyaluronan (HA) is a polymeric glucosaminoglycan that forms a provisional extracellular matrix in diseased vessels. HA is synthesized by 3 different HA synthases (HAS1, HAS2, and HAS3). Aim of this study was to unravel the role of the HAS3 isoenzyme during experimental neointimal hyperplasia.
Kiene LS, Homann S, Suvorava T, Rabausch B, Müller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S, Köhrer K, Savani RC, Grandoch M, Fischer JW.   +15 more
europepmc   +5 more sources

Role for Hyaluronan Synthase 3 in the Response to Vascular Injury. [PDF]

Arterioscler Thromb Vasc Biol, 2016
More than 1.5 million percutaneous coronary interventions are performed annually. The most important long-term complication is restenosis caused by inflammation, neointimal vascular smooth muscle cell (VSMC) hyperplasia, and excess accumulation of extracellular matrix.
Puré E, Krolikoski M, Monslow J.
europepmc   +5 more sources

Expression of hyaluronan synthase 3 in deformed human temporomandibular joint discs: in vivo and in vitro studies

European Journal of Histochemistry, 2010
The present study aimed at investigating the expression of a hyaluronan synthase (HAS) 3 in tissue samples of deformed human temporomandibular joint (TMJ) discs and cells obtained from the discs.
T. Matsumoto, M. Inayama, I. Tojyo, N. Kiga, S. Fujita   +4 more
doaj   +5 more sources

Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group. [PDF]

J Clin Oncol, 2014
PurposeThe strong dose-dependent association between anthracyclines and cardiomyopathy is further exacerbated by the co-occurrence of cardiovascular risk factors (diabetes and hypertension). The high morbidity associated with cardiomyopathy necessitates an understanding of the underlying pathogenesis so that targeted interventions can be developed ...
Wang X, Liu W, Sun CL, Armenian SH, Hakonarson H, Hageman L, Ding Y, Landier W, Blanco JG, Chen L, Quiñones A, Ferguson D, Winick N, Ginsberg JP, Keller F, Neglia JP, Desai S, Sklar CA, Castellino SM, Cherrick I, Dreyer ZE, Hudson MM, Robison LL, Yasui Y, Relling MV, Bhatia S.   +25 more
europepmc   +5 more sources

Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma

Journal of Cancer, 2023
Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck with high metastatic and invasive nature. Super enhancers (SEs) control the expression of cell identity genes and oncogenes during tumorigenesis. As a glycosaminoglycan in the tumor
Quanzhu Chen, Q. Peng, Jing Cai, Y. Liu, Xing-Sheng Lu, Wei Xiong, Zhaoyang Zeng, Guiyuan Li, X. Li, Xiayu Li, Bo Xiang, Mei Yi, . PanChen1   +12 more
semanticscholar   +3 more sources

Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis. [PDF]

Anticancer Agents Med Chem, 2011
Hyaluronan (HA) and hyaluronan synthases (HAS) have been implicated in cancer growth and progression. We previously have shown that HAS3 and HA mediate tumor growth in SW620 colon cancer cells, but the mechanism remains poorly understood. In addition, the effect of HAS3 inhibition on tumor growth with other cells lines has not been explored.
Teng BP, Heffler MD, Lai EC, Zhao YL, LeVea CM, Golubovskaya VM, Bullarddunn KM.   +6 more
europepmc   +5 more sources