Endothelial Hyaluronan Synthase 3 Augments Postischemic Arteriogenesis Through CD44/eNOS Signaling
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Objective: The dominant driver of arteriogenesis is elevated shear stress sensed by the endothelial glycocalyx thereby promoting arterial outward remodeling. Hyaluronan, a critical component of the endothelial glycocalyx, is synthesized by 3 HAS isoenzymes (hyaluronan synthases 1-3) at the plasma membrane.
R. Schneckmann +9 more
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Sesamol regulates AQP3 and HAS2 via MAPK signaling for skin barrier protection an in vitro and molecular docking study [PDF]
Scientific ReportsThe integrity of the skin barrier is crucial for reducing the risk and managing chronic skin conditions such as photoaging, eczema, and atopic dermatitis.
Qiwen Zheng +3 more
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Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes. [PDF]
Journal of Investigative Dermatology, 2002 Three human hyaluronan synthase genes (HAS1, HAS2, and HAS3) have been cloned, but the functional differences between these HAS genes remains obscure. The purpose of this study was to examine which of the HAS genes are selectively regulated in epidermis.
T. Sayo +7 more
semanticscholar +3 more sources
The role of hyaluronan synthase 3 in ventilator-induced lung injury. [PDF]
American Journal of Respiratory and Critical Care Medicine, 2005 We recently found that low-molecular-weight hyaluronan was induced by cyclic stretch in lung fibroblasts and accumulated in lungs from animals with ventilator-induced lung injury. The low-molecular-weight hyaluronan produced by stretch increased interleukin-8 production in epithelial cells, and was accompanied by an upregulation of hyaluronan synthase ...
K. Bai +6 more
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Recombinant human hyaluronan synthase 3 is phosphorylated in mammalian cells. [PDF]
Biochemical Journal, 2006 Hyaluronan is a ubiquitous component of vertebrate extracellular and cell-associated matrices that serves as a key structural component of skin, cartilage, eyes and joints, and plays important roles in dynamic cellular processes, including embryogenesis, inflammation, wound healing and metastasis.
Brian J. Goentzel +2 more
semanticscholar +3 more sources
549 Hyaluronan synthase 3 induces epidermal hyaluronan production by hapten stimulation and modulate contact hypersensitivity response [PDF]
Journal of Investigative Dermatology, 2017 H. Terui, K. Yamasaki, S. Aiba
semanticscholar +2 more sources
Scientific Reports, 2022 Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to identify novel therapeutic targets.
Joseph J. Tonge +7 more
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Mycobacteria exploit host hyaluronan for efficient extracellular replication. [PDF]
PLoS Pathogens, 2009 In spite of the importance of hyaluronan in host protection against infectious organisms in the alveolar spaces, its role in mycobacterial infection is unknown.
Yukio Hirayama +11 more
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Matrix Biology Plus, 2021 In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival.
Arianna Parnigoni +6 more
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Hyaluronic acid synthesis is required for zebrafish tail fin regeneration. [PDF]
PLoS ONE, 2017 Using genome-wide transcriptional profiling and whole-mount expression analyses of zebrafish larvae, we have identified hyaluronan synthase 3 (has3) as an upregulated gene during caudal fin regeneration. has3 expression is induced in the wound epithelium
Xiaohu Ouyang +6 more
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