Results 61 to 70 of about 5,842 (193)

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

Molecules, 2016
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward ...
Valentina Onnis, Monica Demurtas, Alessandro Deplano, Gianfranco Balboni, Anna Baldisserotto, Stefano Manfredini, Salvatore Pacifico, Sandra Liekens, Jan Balzarini   +8 more
doaj   +1 more source

Novel sulindac derivatives: synthesis, characterisation, evaluation of antioxidant, analgesic, anti-inflammatory, ulcerogenic and COX-2 inhibition activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A new series of N′-(substituted phenyl)-2-(1-(4-(methylsulfinyl) benzylidene)−5-fluoro-2-methyl-1H-inden-3-yl) acetohydrazide derivatives (1 – 25) were prepared in good yields in an efficient manner.
Mashooq A. Bhat, Mohamed A. Al-Omar, Nawaf A. Alsaif, Abdulrahman A. Almehizia, Ahmed M. Naglah, Suhail Razak, Azmat Ali Khan, Naeem Mahmood Ashraf   +7 more
doaj   +1 more source

Studies on Girard Hydrazones. II. Polarographic Reduction Mechanisms of Girard Hydrazones

Chemical and Pharmaceutical Bulletin, 1964
Polarographic reduction processes of Girard hydrazones of aliphatic and aromatic ketones were studied. From the results of controlled potential electrolysis, the two-electron reduction process proposed by Prelog and Hafliger for Girard-T Hydrazones of aliphatic and alicyclic ketones was found to be not correct, and a mechanism shown in scheme (4 ...
M, MASUI, H, OHMORI
openaire   +3 more sources

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Enantioselectivity in Transition Metal Catalyzed Propargylic Substitution Reactions: A Theoretical Perspective

Chemistry – A European Journal, EarlyView.
Recent theoretical efforts to elucidate the origin of enantioselectivity in transition metal‐catalyzed propargylic substitution reactions are highlighted in this review. ABSTRACT In recent years, asymmetric catalytic propargylic substitution reactions have undergone remarkable development, enabling the construction of chiral carbon centers adjacent to ...
Ken Sakata, Yoshiaki Nishibayashi
wiley   +1 more source

An overview on synthetic aspects and biological activity profiles of hydrazone derivatives

Discover Chemistry
In the realm of medicinal chemistry, hydrazide-hydrazones represent a versatile class of compounds that have attracted significant attention due to their structural flexibility with respect to molecular design and wide-ranging biological activities ...
K. Nagaraj Pai, K. Subrahmanya Bhat
doaj   +1 more source

N′-[(E)-4-Chlorobenzylidene]-2-(2,3-dimethylanilino)benzohydrazide

IUCrData, 2017
In the title compound, C22H20ClN3O, the dihedral angle between the planes of the chlorophenyl and dimethylphenyl rings is 66.50 (9)°. These rings make dihedral angles 47.79 (8) and 69.24 (9)°, respectively, with the central benzene ring.
Jerry P. Jasinski, Mehmet Akkurt, Shaaban K. Mohamed, Evan M. Dunkley, Mustafa R. Albayati   +4 more
doaj   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Heteropolyacids in synthesis of benzoyl hydrazone derivatives

Bulletin of the Chemical Society of Ethiopia, 2009
Keggin type of heteropolyacids as green reusable and efficient catalyst was used in the synthesis of benzoyl hydrazones from reaction of benzoic acid hydrazide and aldehyde and ketone derivatives.
Sodeh Sadjadi, Majid M. Heravi, Negar Mokhtari Haj, Hossein A.Oskooie, Rahim Hekmat Shoar, Fatemeh F. Bamoharram   +5 more
doaj