New Route Synthesis of Thiadiazoles, Bisthiadiazoles, Thiadiazolotriazines, and Pyrazolothiadiazoles Based on Hydrazonoyl Halides and Dihydrazinylthiadiazole [PDF]
Molecules, 2017 Synthesis and characterization of new thiadiazoles, bisthiadiazoles from the reaction of mono- and di-hydrazonoyl halides with various hydrazinecarbodithioate derivatives were studied.
Abdelwahed R. Sayed, Shar Saad Al-Shihry
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Design, Synthesis, and Biological Evaluations of Novel Azothiazoles Based on Thioamide [PDF]
Current Issues in Molecular Biology, 2022 Herein we studied the preparation of different thiazoles via the reaction of 2-(3,4-dimethoxybenzylidene)hydrazine-1-carbothioamide (1) with hydrazonoyl halides under base-catalyzed conditions.
Abdelwahed R. Sayed +4 more
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A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest [PDF]
Journal of Advanced Research, 2016 This review covers a summary of the literature data published on the chemistry of bis-hydrazonoyl halides over the last four decades. The biological activities of some of the bis-heterocyclic compounds obtained from these bis-hydrazonoyl halides are also
Ahmad Sami Shawali
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Angular Regioselective Synthesis of Varied Functionalized Hexahydro-1,2,4-triazolo[4,3-a]quinazolin-9-ones and Their Antiproliferative Action. [PDF]
Molecules, 2023 New 2-thioxopyrimidin-4-ones capable of participating in regioselective reactions with functionally diverse hydrazonoyl chlorides towards angular regioisomers, rather than linear ones, were designed and synthesized to form stereoisomeric cis- and trans ...
Said AI +4 more
europepmc +3 more sources
Synthesis and In Silico Study of Some New bis-[1,3,4]thiadiazolimines and bis-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease [PDF]
Current Issues in Molecular Biology, 2022 A novel series of bis-[1,3,4]thiadiazolimines, and bis-thiazolimines, with alkyl linker, were synthesized through general routes from cyclization of 1,1′-(hexane-1,6-diyl)bis(3-phenylthiourea) and hydrazonoyl halides or α-haloketones, respectively ...
Sobhi M. Gomha +7 more
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Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase [PDF]
Molecules, 2023 One crucial strategy for the treatment of breast cancer involves focusing on the Vascular Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the development of new (VEGFR-2) inhibitors is of the utmost importance. In this study,
Tariq Z. Abolibda +4 more
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Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents [PDF]
Frontiers in Chemistry, 2022 A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst.
Latifah A. Alshabanah +5 more
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Synthesis and characterization of novel heterocycles based on tetrazine and hydrazonoyl halides [PDF]
European Journal of Chemistry, 2014 The present work describes the preparation and characterization of new pyridazine, thiohydrazonate, bis -pyrazole, bis -triazole and polypyrazoles based on tetrazine and hydrazonoyl halides. The structures of the newly synthesized were elucidated on the basis of their spectral data FT-IR, NMR, Mass and elemental analysis.
Abdelwahed Rashad Sayed +2 more
openaire +4 more sources
Synthesis, Molecular Docking, and Dynamic Simulation Targeting Main Protease (Mpro) of New, Thiazole Clubbed Pyridine Scaffolds as Potential COVID-19 Inhibitors. [PDF]
Curr Issues Mol Biol, 2023 Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors.
Alghamdi A +7 more
europepmc +3 more sources
Utility of 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of novel 1,3,4-thiadiazoles or 1,3-thiazoles and study their cytotoxic activity [PDF]
Scientific ReportsOne of the biggest causes of death around the world is cancer. Despite the development of a variety of chemotherapeutic drugs that stop excessive cell division, drug resistance remains a major obstacle to chemotherapy.
Anhar Abdel-Aziem, Abdou O. Abdelhamid
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