New Route Synthesis of Thiadiazoles, Bisthiadiazoles, Thiadiazolotriazines, and Pyrazolothiadiazoles Based on Hydrazonoyl Halides and Dihydrazinylthiadiazole [PDF]
Molecules, 2017 Synthesis and characterization of new thiadiazoles, bisthiadiazoles from the reaction of mono- and di-hydrazonoyl halides with various hydrazinecarbodithioate derivatives were studied.
Abdelwahed R. Sayed, Shar Saad Al-Shihry
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Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole–Thiazole Hybrids as Potent Colon Cancer Inhibitors [PDF]
ChemistryOpenIn this study, a series of novel benzimidazothiazole–thiazole hybrids is synthesized via the condensation of 2‐(1‐(3‐methylbenzoimidazo[2,1‐b]thiazol‐2‐yl)ethylidene)hydrazine‐1‐carbothioamide with various hydrazonoyl halides and α‐halo compounds ...
Bader Huwaimel +6 more
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Design, Synthesis, and Biological Evaluations of Novel Azothiazoles Based on Thioamide [PDF]
Current Issues in Molecular Biology, 2022 Herein we studied the preparation of different thiazoles via the reaction of 2-(3,4-dimethoxybenzylidene)hydrazine-1-carbothioamide (1) with hydrazonoyl halides under base-catalyzed conditions.
Abdelwahed R. Sayed +4 more
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A review on bis-hydrazonoyl halides: Recent advances in their synthesis and their diverse synthetic applications leading to bis-heterocycles of biological interest [PDF]
Journal of Advanced Research, 2016 This review covers a summary of the literature data published on the chemistry of bis-hydrazonoyl halides over the last four decades. The biological activities of some of the bis-heterocyclic compounds obtained from these bis-hydrazonoyl halides are also
Ahmad Sami Shawali
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Reaction of Nitrilimines with Pyruvaldehyde Hydrazones: Synthesis and Antimicrobial Evaluation of Some New 1,2,4-Triazole Derivatives [PDF]
Journal of Chemistry, Volume 2015, Issue 1, 2015., 2015 A new series of 1,3,4,5,5‐pentasubstituted‐1,2,4‐triazoles (4a–j, 6a–j) have been synthesized by the 1,3‐dipolar cycloaddition of suitable nitrilimines 2 to pyruvaldehyde (2‐oxopropanal) hydrazones having (COPh, COOMe, COOEt, Me/Me, and Me/Ph) groups 3 and 5.
Hany M. Dalloul, Sevgi Kolaylı
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Angular Regioselective Synthesis of Varied Functionalized Hexahydro-1,2,4-triazolo[4,3-a]quinazolin-9-ones and Their Antiproliferative Action [PDF]
Molecules, 2023 New 2-thioxopyrimidin-4-ones capable of participating in regioselective reactions with functionally diverse hydrazonoyl chlorides towards angular regioisomers, rather than linear ones, were designed and synthesized to form stereoisomeric cis- and trans ...
Gajdács Márió +4 more
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Synthesis and In Silico Study of Some New bis-[1,3,4]thiadiazolimines and bis-Thiazolimines as Potential Inhibitors for SARS-CoV-2 Main Protease [PDF]
Current Issues in Molecular Biology, 2022 A novel series of bis-[1,3,4]thiadiazolimines, and bis-thiazolimines, with alkyl linker, were synthesized through general routes from cyclization of 1,1′-(hexane-1,6-diyl)bis(3-phenylthiourea) and hydrazonoyl halides or α-haloketones, respectively ...
Sobhi M. Gomha +7 more
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Concomitant colour polymorphs of (Z)-N-(4-fluorophenyl)-2-oxopropanehydrazonoyl chloride. [PDF]
Acta Crystallogr C Struct Chem(Z)‐N‐(4‐Fluorophenyl)‐2‐oxopropanehydrazonoyl chloride forms concomitant colour polymorphs, namely, block‐shaped pale‐orange crystals of form I (space group P21/n, Z = 4) and needle‐shaped pale‐yellow crystals of form II (space group P21/c, Z = 4).The title compound, (Z)‐N‐(fluorophenyl)‐2‐oxopropanehydrazonoyl chloride, C9H8ClFN2O, was found to form ...
Müller L +3 more
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Electrochemical synthesis of pyrazolines and pyrazoles via [3+2] dipolar cycloaddition [PDF]
Angewandte Chemie International Edition, Volume 62, Issue 9, February 20, 2023., 2023 Pyrazolines and pyrazoles are common and important motifs of pharmaceutical agents and agrochemicals. Herein, the first electrochemical approach for their direct synthesis from easily accessible hydrazones and dipolarophiles up to decagram scale is ...
Bär, Robin M. +5 more
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Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase [PDF]
Molecules, 2023 One crucial strategy for the treatment of breast cancer involves focusing on the Vascular Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the development of new (VEGFR-2) inhibitors is of the utmost importance. In this study,
Tariq Z. Abolibda +4 more
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