Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents [PDF]
A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst.
Latifah A. Alshabanah +5 more
doaj +2 more sources
Synthesis and characterization of novel heterocycles based on tetrazine and hydrazonoyl halides [PDF]
The present work describes the preparation and characterization of new pyridazine, thiohydrazonate, bis-pyrazole, bis-triazole and polypyrazoles based on tetrazine and hydrazonoyl halides.
Argyropoulos +5 more
core +3 more sources
Synthetic Strategies to Access Fluorinated Azoles. [PDF]
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
El-Gaber MKA +4 more
europepmc +2 more sources
Controlling (E/Z)‐Stereoselectivity of −NHC=O Chlorination: Mechanism Principles for Wide Scope Applications [PDF]
Organic halogen compounds are cornerstones of applied chemical sciences. Halogen substitution is a smart molecular design strategy adopted to influence reactivity, membrane permeability and receptor interaction.
Aoyama, H +3 more
core +2 more sources
Synthesis, molecular docking, and dynamic simulation targeting main protease (Mpro) of new, Thiazole clubbed pyridine scaffolds as potential COVID-19 inhibitors [PDF]
Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors.
Abouzied, Amr S. +7 more
core +2 more sources
Utility of 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of novel 1,3,4-thiadiazoles or 1,3-thiazoles and study their cytotoxic activity [PDF]
One of the biggest causes of death around the world is cancer. Despite the development of a variety of chemotherapeutic drugs that stop excessive cell division, drug resistance remains a major obstacle to chemotherapy.
Anhar Abdel-Aziem, Abdou O. Abdelhamid
doaj +2 more sources
Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety [PDF]
Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity.
Amr S. Abouzied +7 more
doaj +2 more sources
Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies [PDF]
Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and the appropriate hydrazonoyl halides in the presence of a few drops of diisopropylethylamine.
Huda R. M. Rashdan +4 more
doaj +2 more sources
Synthesis of new functionalized derivatives of indolo[2,3-e][1,2,4]-triazolo-[4,5-b]-1,2,4-triazine [PDF]
New functionalized 1,2,4-triazolo-[4,3-b]-1,2,4-triazino-[5,6-b]indole derivatives were synthesized via reaction of the hydrazonoyl halides with 5H-2,3-dihydro-1,2,4-triazino[5,6-b]indole-3-thione or its 3-methylthio derivative.
Gomha Sobhi M., Abdel-Aziz Hatem A.
doaj +1 more source
1,3‐dipolar cycloaddition of cyclic enones with 2,5‐disubstituted nitrile‐imines obtained by photochemical activation of 2,5‐diaryl substituted tetrazoles leads to the formation of novel pyrazoles and pyrazolines. Reactions can be monitored using UV‐vis absorption and emission measurements.
Chiraz Labassi +4 more
wiley +1 more source

