Results 11 to 20 of about 562 (194)

Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents [PDF]

Frontiers in Chemistry, 2022
A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst.
Latifah A. Alshabanah, Laila A. Al-Mutabagani, Sobhi M. Gomha, Sobhi M. Gomha, Hoda A. Ahmed, Hoda A. Ahmed   +5 more
doaj   +2 more sources

Synthesis and characterization of novel heterocycles based on tetrazine and hydrazonoyl halides [PDF]

European Journal of Chemistry, 2014
The present work describes the preparation and characterization of new pyridazine, thiohydrazonate, bis-pyrazole, bis-triazole and polypyrazoles based on tetrazine and hydrazonoyl halides.
Argyropoulos, Boger, Boulton, Sayed, Tisler, Ungureanu   +5 more
core   +3 more sources

Synthetic Strategies to Access Fluorinated Azoles. [PDF]

European J Org Chem
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
El-Gaber MKA, Djugovski M, Huang TY, Adhikari S, Roy S.   +4 more
europepmc   +2 more sources

Controlling (E/Z)‐Stereoselectivity of −NHC=O Chlorination: Mechanism Principles for Wide Scope Applications [PDF]

Chemistry – A European Journal, Volume 30, Issue 60, October 28, 2024.
Organic halogen compounds are cornerstones of applied chemical sciences. Halogen substitution is a smart molecular design strategy adopted to influence reactivity, membrane permeability and receptor interaction.
Aoyama, H, Elgazar, AA, Maklad, RM, Moustafa, GAI   +3 more
core   +2 more sources

Synthesis, molecular docking, and dynamic simulation targeting main protease (Mpro) of new, Thiazole clubbed pyridine scaffolds as potential COVID-19 inhibitors [PDF]

Curr Issues Mol Biol, 2023
Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors.
Abouzied, Amr S., Alamri, Abdulwahab, Alghamdi, Adel, Ansari, Mukhtar, Anwar, Sirajudheen, Gomha, Sobhi M., Khadra, Ibrahim, Zaki, Yasser H.   +7 more
core   +2 more sources

Utility of 3-(2-oxo-2H-chromen-3-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde in the synthesis of novel 1,3,4-thiadiazoles or 1,3-thiazoles and study their cytotoxic activity [PDF]

Scientific Reports
One of the biggest causes of death around the world is cancer. Despite the development of a variety of chemotherapeutic drugs that stop excessive cell division, drug resistance remains a major obstacle to chemotherapy.
Anhar Abdel-Aziem, Abdou O. Abdelhamid
doaj   +2 more sources

Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety [PDF]

Molecules, 2022
Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity.
Amr S. Abouzied, Jehan Y. Al-Humaidi, Abdulrahman S Bazaid, Husam Qanash, Naif K. Binsaleh, Abdulwahab Alamri, Sheikh Muhammad Ibrahim, Sobhi M. Gomha   +7 more
doaj   +2 more sources

Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies [PDF]

Molecules, 2022
Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and the appropriate hydrazonoyl halides in the presence of a few drops of diisopropylethylamine.
Huda R. M. Rashdan, Mohamad T. Abdelrahman, Ihsan A. Shehadi, Sara S. El-Tanany, Bahaa A. Hemdan   +4 more
doaj   +2 more sources

Synthesis of new functionalized derivatives of indolo[2,3-e][1,2,4]-triazolo-[4,5-b]-1,2,4-triazine [PDF]

Journal of the Serbian Chemical Society, 2013
New functionalized 1,2,4-triazolo-[4,3-b]-1,2,4-triazino-[5,6-b]indole derivatives were synthesized via reaction of the hydrazonoyl halides with 5H-2,3-dihydro-1,2,4-triazino[5,6-b]indole-3-thione or its 3-methylthio derivative.
Gomha Sobhi M., Abdel-Aziz Hatem A.
doaj   +1 more source

Photoinduced 1,3‐Dipolar Cycloadditions of Cyclic Enones and 2,5‐Disubstituted Tetrazoles: An Unprecedented Pathway to Polysubstituted Pyrazolines and Pyrazoles

European Journal of Organic Chemistry, Volume 26, Issue 47, December 13, 2023., 2023
1,3‐dipolar cycloaddition of cyclic enones with 2,5‐disubstituted nitrile‐imines obtained by photochemical activation of 2,5‐diaryl substituted tetrazoles leads to the formation of novel pyrazoles and pyrazolines. Reactions can be monitored using UV‐vis absorption and emission measurements.
Chiraz Labassi, Nicolas Fournier‐Le Ray, Fabienne Gauffre, Jean‐Luc Fillaut, Rafik Gatri   +4 more
wiley   +1 more source