Reactions with hydrazonoyl halides: Part XVIII-Synthesis of pyrrolidino[3,4-c] pyrazole, pyrazolo[3,4-d]pyridazine, imidazo-[1,2-a ]pyridine, pyrazolo[3,4-d]pyrimidine and other heterocyclic derivatives [PDF]
, 1997 880 ...
Abdelhamid, Abdou O, Emam, Hussein A
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Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents. [PDF]
Front Chem, 2021 A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst.
Alshabanah LA +3 more
europepmc +2 more sources
Reaction with hydrazonoyl halides XXIII [1]: Synthesis and reactions of C‐coumarinoyl‐N‐arylformohydrazonoyl bromides [PDF]
Heteroatom Chemistry, 1999 Abdou O. Abdelhamid, Gaber S. Mohamed
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Journal of Chemical Research, 2008 Reaction of hydrazonoyl halides 1 with 2-(aroylmethyl)-6-methylpyrimidin-4(3H)-ones 3 proved to be site selective and gave 2-(3-acetyl-1,5-diarylpyrazol-4-yl)-6-methylpyrimidin-4(3H)-ones 5 via dehydrative cyclisation of the hydrazone intermediates 4. The structures of both 4 and 5 were elucidated by spectral data and alternative synthesis.
Thoraya A. Farghaly, Ahmad S. Shawali
openaire +4 more sources
Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety. [PDF]
Molecules, 2022 Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity.
Abouzied AS +7 more
europepmc +2 more sources
Synthesis of new functionalized derivatives of indolo[2,3-e][1,2,4]-triazolo-[4,5-b]-1,2,4-triazine [PDF]
Journal of the Serbian Chemical Society, 2013 New functionalized 1,2,4-triazolo-[4,3-b]-1,2,4-triazino-[5,6-b]indole derivatives were synthesized via reaction of the hydrazonoyl halides with 5H-2,3-dihydro-1,2,4-triazino[5,6-b]indole-3-thione or its 3-methylthio derivative.
Gomha Sobhi M., Abdel-Aziz Hatem A.
doaj +1 more source
Synthesis of novel thiazole, pyranothiazole, thiazolo[4,5-b]pyridines and thiazolo[5',4':5,6]pyrano[2,3-d]pyrimidine derivatives and incorporating isoindoline-1,3-dione group. [PDF]
BMC Chem, 2019 Background Thiazole is a core structural motif presents in a wide range of natural products. Thiazole derivatives also have a wide range of medicinal and biological properties. Results The reaction of hydrazonoyl halides with 2-(1-(4-(1,3-dioxoisoindolin-
Hosny MA +3 more
europepmc +2 more sources
Utility of 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity. [PDF]
BMC Chem, 2019 Background Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores with a wide range of biological ...
Abdelhamid AO +5 more
europepmc +2 more sources
Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies. [PDF]
Molecules, 2022 Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and the appropriate hydrazonoyl halides in the presence of a few drops of diisopropylethylamine.
Rashdan HRM +4 more
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