Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase [PDF]
Molecules, 2023 One crucial strategy for the treatment of breast cancer involves focusing on the Vascular Endothelial Growth Factor Receptor (VEGFR-2) signaling system. Consequently, the development of new (VEGFR-2) inhibitors is of the utmost importance. In this study,
Tariq Z. Abolibda +4 more
doaj +2 more sources
Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents [PDF]
Frontiers in Chemistry, 2022 A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst.
Latifah A. Alshabanah +5 more
doaj +2 more sources
Synthesis, Molecular Docking, and Dynamic Simulation Targeting Main Protease (Mpro) of New, Thiazole Clubbed Pyridine Scaffolds as Potential COVID-19 Inhibitors. [PDF]
Curr Issues Mol Biol, 2023 Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors.
Alghamdi A +7 more
europepmc +3 more sources
Controlling (E/Z)‐Stereoselectivity of −NHC=O Chlorination: Mechanism Principles for Wide Scope Applications [PDF]
Chemistry – A European Journal, Volume 30, Issue 60, October 28, 2024.Organic halogen compounds are cornerstones of applied chemical sciences. Halogen substitution is a smart molecular design strategy adopted to influence reactivity, membrane permeability and receptor interaction.
Aoyama, H +3 more
core +2 more sources
Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety [PDF]
Molecules, 2022 Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity.
Amr S. Abouzied +7 more
doaj +2 more sources
, 2011 The potassium salts of thiocarboxanilide of 2- phenylimino-3-phenyl-4-thiazolidinone and 1,3- diphenyl-2-thioxo-4-imidazolone react with hydrazonoyl halides in N,N-dimethylformamide to afford the corresponding 1,3,4-thiadiazoline derivatives.
Hamdi M. Hassaneen +3 more
openalex +3 more sources
Synthesis of novel thiazole, pyranothiazole, thiazolo[4,5-b]pyridines and thiazolo[5′,4′:5,6]pyrano[2,3-d]pyrimidine derivatives and incorporating isoindoline-1,3-dione group [PDF]
BMC Chemistry, 2019 Background Thiazole is a core structural motif presents in a wide range of natural products. Thiazole derivatives also have a wide range of medicinal and biological properties. Results The reaction of hydrazonoyl halides with 2-(1-(4-(1,3-dioxoisoindolin-
Mona A. Hosny +3 more
doaj +2 more sources
Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies [PDF]
Molecules, 2022 Novel 1,3,4-thiadiazole derivatives were synthesized through the reaction of methyl 2-(4-hydroxy-3-methoxybenzylidene) hydrazine-1-carbodithioate and the appropriate hydrazonoyl halides in the presence of a few drops of diisopropylethylamine.
Huda R. M. Rashdan +4 more
doaj +2 more sources
Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds [PDF]
Molecules, 2022 Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists.
Sobhi M. Gomha +4 more
doaj +2 more sources
HETEROCYCLES, 1988 Reaction de la p-methoxyphenyl-2 phenyl-4 oxazoline-2one-5 avec les [N-aryl chloro] formohydrazonoyl formiate d'alkyle: obtention d'aryl-1 p-methoxybenzamido-4 oxo-5 phenyl-4 pyrazoline-2carboxylates-3 principalement et des esters d'alkyle et [aryl-2' (p-methoxyphenyl-2 phenyl-4 oxazolyl-5)-2'] hydrazides de l'acide oxalique et de derives de ...
Maria Luisa Gelmi +4 more
openalex +3 more sources