Results 91 to 100 of about 976,699 (171)

Assessment of the antiprotozoal activity of some tubulin inhibitors following cyclodextrin complexation [PDF]

, 2002
The purpose of the present study was to evaluate the potential usefulness of tubulin inhibitors when complexed with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) against a range of protozoan parasites.
Menon, Kathleen I.
core  

(S)-2-Hydroxyprophyl-β-cyclodextrin, a new chiral stationary phase for reversed-phase liquid chromatography

, 1990
(S)-2- and (R,S)-2-hydroxypropyl-β-cyclodextrin have been bonded to silica gel and evaluated as stationary phases for reversed-phase liquid chromatography. Stationary phases also were prepared on two silicas having different pore sizes and surface areas.
Josef Pitha, Armstrong, Daniel W., Apryll M. Stalcup, Stalcup, Apryll M., Pitha, Josef, San-Chun Chang, Daniel W. Armstrong, Chang, San Chun   +7 more
core   +1 more source

The development of an innovative method to improve the dissolution performance of rivaroxaban

Heliyon
Recent advancements in the formulation of solid dosage forms involving active ingredient-cyclodextrin complexes have garnered considerable attention in pharmaceutical research. While previous studies predominantly focused on incorporating these complexes
Emma Adriana Ozon, Erand Mati, Oana Karampelas, Valentina Anuta, Iulian Sarbu, Adina Magdalena Musuc, Raul-Augustin Mitran, Daniela C. Culita, Irina Atkinson, Mihai Anastasescu, Dumitru Lupuliasa, Mirela Adriana Mitu   +11 more
doaj   +1 more source

Sodium Dithionite Reduction of 2S,5R-(−)-menthone and R-(+)-pulegone in the Presence of β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin

, 2003
Menthone on reduction with sodium dithionite, showed a good amount of menthol formation in the water/DMF system, with increasing β-cyclodextrin (β-CD) concentration from 47.0% for 0.1 equivalent of β-CD to 93.5% for 1 equivalent of β-CD.
Palaniswamy, Ravi, Soundar, Divakar
core  

STUDY OF INCLUSION COMPLEXES OF 2-HYDROXYPROPYL-β-CYCLODEXTRIN WITH BIOLOGICALLY ACTIVE SALINAZIDE AND VANILIN ISONIAZIDE

, 2017
Complexation of 2-hydroxypropyl-β-cyclodextrin with salinazide and vanillin isoniazide possessing broncholytic and antitubercular activity was studied by the UV-spectroscopy method in a phosphate buffer solution (рН 7.4).The solubilizing effect of ...
Svetlana V. Blokhina, Marina V. Ol’khovich, Alexander N. Trostin, Angelika V. Sharapova   +3 more
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Combined effect of hydroxypropylmethylcellulose and hydroxypropyl-beta-cyclodextrin on physicochemical and dissolution properties of celecoxib

, 2007
Investigation on the influence of hydroxypropyl methylcellulose (HPMC) on solubility and dissolution properties of celecoxib/hydroxypropyl-β-cyclodextrin system was carried out, with the ultimate goal of enhancing the drug bioavailability. 1H-NMR and 13C-
MIRO, AGNESE, CAPPELLO, BRUNELLA, IERVOLINO, MARIA, DI MAIO C   +3 more
core   +1 more source

Porous Composite Polymers Composed of Polyethyleneimine and Cyclodextrins: Synthesis and Application as Adsorbents for an Organic Compound

Separations
Polyethyleneimine-based porous composites have been prepared by ring-opening polymerization of 2,2-bishydroxymethylbutanol-tris[3-(1-aziridinyl)propionate] (3AZ), a tri-aziridine compound, in water, in the presence of cyclodextrins (CDs), i.e., α-CD, γ ...
Naofumi Naga, Yuma Miyazaki, Tamaki Nakano   +2 more
doaj   +1 more source

Surfactant Inclusions by Modified β-Cyclodextrins

, 1991
Binding constants for the inclusion of sodium alkane-1-sulfonates (C5-C10, C12) by four modified β- cyclodextrins (2,6-O-dimethyl-β-cyclodextrin, 2,3,6-O-trimethyl-β-cyclodextrin, hydroxypropyl-β-cyclodextrin and maltosyl-β-cyclodextrin ) were ...
CD Lavandier, MP Pelletier, VC Reinsborough   +2 more
core   +1 more source

Enhancing the Drug Release and Physicochemical Properties of Rivaroxaban via Cyclodextrin Complexation: A Comprehensive Analytical Approach

Pharmaceuticals
Background/Objectives: Rivaroxaban, an oral anticoagulant, shows poor aqueous solubility, posing significant challenges to its bioavailability and therapeutic efficiency.
Cristina Solomon, Valentina Anuța, Iulian Sarbu, Emma Adriana Ozon, Adina Magdalena Musuc, Veronica Bratan, Adriana Rusu, Vasile-Adrian Surdu, Cătălin Croitoru, Abhay Chandak, Roxana Mariuca Gavriloaia, Teodora Dalila Balaci, Denisa Teodora Niță, Mirela Adriana Mitu   +13 more
doaj   +1 more source

Sufentanil-2-hydroxypropyl-β-cyclodextrin Inclusion Complex For Pain Treatment: Physicochemical, Cytotoxicity, And Pharmacological Evaluation

, 2015
Sufentanil (SUF) is a synthetic analgesic opioid widely used for the management of acute and chronic pain. This drug was complexed with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and the physicochemical characterization, in vitro/ex vivo toxicity assays ...
Cereda C.M.S., de Paula E., Yokaichiya F., Fraceto L.F., Franco M.K.K.D., Tofoli G.R., Braga A.F.A., de Araujo D.R., Nunes L.A.S., Volobuef C., Moraes C.M.   +10 more
core   +1 more source