Results 81 to 90 of about 15,368 (164)

Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]

, 2017
The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia, Dardis, Andrea, DE STEFANO, Maria Egle, Dragotto, Jessica, Erickson, Robert P., Fiorenza, Maria Teresa, Mangia, Franco, Zampieri, Stefania   +7 more
core   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

The Zebrafish (Danio rerio) Is a Relevant Model for Studying Sex-Specific Effects of 17β-Estradiol in the Adult Heart [PDF]

, 2019
Cardiovascular diseases are a major cause of morbidity and mortality, and there are significant sex differences therein. However, the underlying mechanisms are poorly understood.
Hassel, David, Hein, Selina, Kararigas, Georgios   +2 more
core   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Maternal and Foetal Cardiovascular Effects of the Anaesthetic Alfaxalone in 2-Hydroxypropyl-β-cyclodextrin in the Pregnant Ewe

The Scientific World Journal, 2013
The objective of this study was to determine the pharmacodynamics effects of the anaesthetic alfaxalone in 2-hydroxypropyl-β-cyclodextrin in pregnant sheep after the intravenous injection of a 2 mg/kg weight dose.
Anna Andaluz, Laura Santos, Félix García, Rosa I. Ferrer, Laura Fresno, Xavier Moll   +5 more
doaj   +1 more source

Synthetic Lethality of Chk1 Inhibition Combined with p53 and/or p21 Loss During a DNA Damage Response in Normal and Tumor Cells [PDF]

, 2013
Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by ...
A Besson, A Eastman, A Goga, A Goloudina, A Z Munir, AA Levesque, AA Levesque, AJ Fikaris, AN Tse, AT Ferguson, B Xu, C Tapia, CJ Sherr, CS Sorensen, CX Ma, EA Kohn, EA Kohn, F Bunz, FI Raynaud, H Piwnica-Worms, H Zhao, I Hassepass, J Bartkova, J Falck, K Shimuta, L S White, LL Parker, MH Lam, MV Cespedes, O Gilad, O Wang, OA Sedelnikova, PM Fracasso, R Di Micco, R Rodriguez, RP Perez, RT Bunch, S Origanti, S-r Cai, SD Zabludoff, T Abbas, T Waldman, WR Taylor, Y Luo   +43 more
core   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Enantioselective Determination of Amphetamine‐Type Stimulants in Environmental Waters Using SPE and CE–MS/MS

ELECTROPHORESIS, Volume 47, Issue 3, Page 250-260, March 2026.
ABSTRACT The growing concern over drug abuse, particularly involving amphetamine‐type substances (ATS), has led to their monitoring in environmental waters. These chiral compounds, commonly found in river water and wastewater treatment plant (WWTP) effluents, require analytical methods capable of enantiomeric discrimination, as their enantiomers can ...
Pol Clivillé‐Cabré, Francesc Borrull, Carme Aguilar, Marta Calull   +3 more
wiley   +1 more source

Adenosine Encapsulation and Characterization through Layer-by-Layer Assembly of Hydroxypropyl-β-Cyclodextrin and Whey Protein Isolate as Wall Materials

Molecules
Adenosine, as a water-soluble active substance, has various pharmacological effects. This study proposes a layer-by-layer assembly method of composite wall materials, using hydroxypropyl-β-cyclodextrin as the inner wall and whey protein isolate as the ...
Yudie Jin, Suning Zhang
doaj   +1 more source

Space filling of β-cyclodextrin and β-cyclodextrin derivatives by volatile hydrophobic guests

Beilstein Journal of Organic Chemistry, 2013
The inclusion of volatile derivatives of benzene and cyclohexane in β-cyclodextrin (β-CD), hydroxypropyl-β-CD, and hydrophilic β-CD-thioethers was investigated by static headspace gas chromatography (HS-GC) and molecular modelling.
Sophie Fourmentin, Anca Ciobanu, David Landy, Gerhard Wenz   +3 more
doaj   +1 more source