Results 1 to 10 of about 4,383 (214)
St. John’s Wort Extract Increases Pgp Expression in the Brain but Not in the Small Intestine or the Liver of Wistar Rats [PDF]
Pharmacology Research & PerspectivesSt John's Wort (SJW), commonly used to treat mild depression, is known to pose a risk of drug–herb interactions through hyperforin‐mediated activation of the pregnane X receptor (PXR).
Valerio Taggi +3 more
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Frontiers in Immunology, 2021 Hyperforin is a major active constituent of Hypericum perforatum L. extract, which is widely used for the treatment of depressive disorders. Recent studies have reported that hyperforin reduced inflammation in stroke and suppressed proliferation and ...
Fangyuan Zhang, Yan Wu
exaly +3 more sources
Hyperforin, the major metabolite of St. John’s wort, exhibits pan-coronavirus antiviral activity [PDF]
Frontiers in MicrobiologyIntroductionThe COVID-19 pandemic caused by the SARS-CoV-2 virus has underscored the urgent necessity for the development of antiviral compounds that can effectively target coronaviruses.
Imelda Raczkiewicz +15 more
doaj +2 more sources
Quantitative Profiling of Phenolic Constituents in Hypericum perforatum L. via HPLC–PDA and HPLC–ECD: A Chemometric Approach [PDF]
Molecules(1) Background: Medicinal plants are widely used in folk medicine. Hypericum perforatum L. (St. John’s wort) is a medicinal plant that is used domestically and exported to other countries.
Andrin Tahiri, Zamir Damani, Dritan Topi
doaj +2 more sources
Antimicrobial and Antiherpetic Properties of Nanoencapsulated Hypericum perforatum Extract [PDF]
PharmaceuticalsBackground/Objectives: This study aims to gain insights into the antimicrobial and antiherpetic activity of hyperforin-rich Hypericum perforatum L. (HP) extract using nanostructured lipid carriers (NLCs) as delivery platforms.
Yoana Sotirova +7 more
doaj +2 more sources
Tetrahydrohyperforin and octahydrohyperforin are two new potent inhibitors of angiogenesis. [PDF]
PLoS ONE, 2010 We have previously shown that hyperforin, a phloroglucinol derivative found in St. John's wort, behaves as a potent anti-angiogenic compound. To identify the reactive group(s) mainly involved in this anti-angiogenic effect, we have investigated the anti ...
Beatriz Martínez-Poveda +4 more
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Hypericum perforatum: Traditional uses, clinical trials, and drug interactions [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Hypericum perforatum (Hypericaceae), known as Saint John’s wort (SJW), has been used in different systems of traditional medicine such as Chinese traditional medicine, Greek traditional medicine, and Islamic traditional medicine. The plant and its active
Seyedeh Zahra Nobakht +4 more
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Plant Direct, 2021 Hyperforin, a major bioactive constituent of Hypericum concentration, is impacted by various phenological phases and soil characteristics. We aimed to design a model predicting hyperforin content in Hypericum perforatum based on different ecological and ...
Maryam Saffariha +2 more
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Journal of Taibah University for Science, 2021 The role of hyperforin in combination anticancer therapy remain unknown. In this study, several doses of combination treatment (paclitaxel and hyperforin) were introduced to the Michigan Cancer Foundation (MCF)-7 cell culture for 24 h.
Muttiah Barathan +4 more
doaj +1 more source
Molecules, 2023 Oxidative stress and the hypoxic microenvironment play a key role in the progression of human melanoma, one of the most aggressive skin cancers. The aim of our study was to evaluate the effect of Hypericum perforatum extracts of different origins (both ...
Aleksandra Brankiewicz +8 more
doaj +1 more source