St. John’s Wort Extract Increases Pgp Expression in the Brain but Not in the Small Intestine or the Liver of Wistar Rats [PDF]
Pharmacology Research & PerspectivesSt John's Wort (SJW), commonly used to treat mild depression, is known to pose a risk of drug–herb interactions through hyperforin‐mediated activation of the pregnane X receptor (PXR).
Valerio Taggi +3 more
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Hyperforin potentiates polymyxin B against multidrug-resistant Gram-negative pathogens via membrane disruption, biofilm eradication, and oxidative stress [PDF]
Antimicrobial Agents and ChemotherapyThe escalating spread of multidrug-resistant (MDR) Gram-negative pathogens, particularly Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii, has severely undermined the efficacy of polymyxin B, one of the few remaining last-line ...
Maytham Hussein +9 more
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Antimicrobial and Antiherpetic Properties of Nanoencapsulated Hypericum perforatum Extract [PDF]
PharmaceuticalsBackground/Objectives: This study aims to gain insights into the antimicrobial and antiherpetic activity of hyperforin-rich Hypericum perforatum L. (HP) extract using nanostructured lipid carriers (NLCs) as delivery platforms.
Yoana Sotirova +7 more
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Hyperforin, the major metabolite of St. John’s wort, exhibits pan-coronavirus antiviral activity [PDF]
Frontiers in MicrobiologyIntroductionThe COVID-19 pandemic caused by the SARS-CoV-2 virus has underscored the urgent necessity for the development of antiviral compounds that can effectively target coronaviruses.
Imelda Raczkiewicz +15 more
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Quantitative Profiling of Phenolic Constituents in Hypericum perforatum L. via HPLC–PDA and HPLC–ECD: A Chemometric Approach [PDF]
Molecules(1) Background: Medicinal plants are widely used in folk medicine. Hypericum perforatum L. (St. John’s wort) is a medicinal plant that is used domestically and exported to other countries.
Andrin Tahiri, Zamir Damani, Dritan Topi
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Effects of Growth Phases and Intensification of Light on Secondary Metabolites and Agro-Morphological Traits of the St. John’s Wort (Hypericum perforatum L.) [PDF]
PlantsLight regime and growth phase are significant determinants of agro-morphological traits and secondary metabolite accumulation in plants. This study evaluated the effects of two light conditions on agro-morphological and phytochemical traits of two ...
Mina Sadat Tabatabaei +4 more
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Hyperforin Accumulates in the Translucent Glands of Hypericum perforatum [PDF]
Annals of Botany, 2007 Hypericum perforatum contains the therapeutically important compounds hypericin and hyperforin. Hypericin is known to accumulate in the dark glands. This investigation aimed to determine the accumulation site of hyperforin.Dark and translucent glands as well as non-secretory tissue in leaves were manually isolated under the microscope.
Soelberg, Jens +2 more
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In silico study of the toxicity of hyperforin and its metabolites [PDF]
Pharmacia, 2023 St. John’s wort is a medicinal herb well-known for its antidepressant, anti-inflammatory, antimycotic, and wound-healing properties. Hyperforin, the major phloroglucinol derivative, has been implicated as one of the main contributors to these therapeutic
Ivelin Iliev +3 more
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Transplacental passage of hyperforin, hypericin, and valerenic acid
Frontiers in Pharmacology, 2023 Safe medications for mild mental diseases in pregnancy are needed. Phytomedicines from St. John’s wort and valerian are valid candidates, but safety data in pregnancy are lacking. The transplacental transport of hyperforin and hypericin (from St.
Deborah Spiess +11 more
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Men reporting lasting longer with hyperforin [PDF]
International Brazilian Journal of Urology, 2008 Dapoxetine, a new short lasting selective serotonin reuptake inhibitor (SSRI), has demonstrated clinical efficacy in clinical trials when used immediately before intercourse [1]. However, Dapoxetine has not yet been approved by the regulatory agency in part because of concern of risk and benefit ration of a SSRI in this quality of life condition.
Dae Kyung Kim, Michael B Chancellor
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